A5065141658- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Health and Wellbeing Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Lung Cancer Treatments and Mutations
- Inhalation and Respiratory Drug Delivery
- Lung Cancer Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Occupational exposure and asthma
- Pleural and Pulmonary Diseases
- Cystic Fibrosis Research Advances
- Chronic Disease Management Strategies
- Gastroesophageal reflux and treatments
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Emergency and Acute Care Studies
- Drug-Induced Adverse Reactions
- Pulmonary Hypertension Research and Treatments
- Health Promotion and Cardiovascular Prevention
Hallym University Sacred Heart Hospital
2015-2024
Hallym University
2012-2022
Hallym University Medical Center
2009-2022
Konkuk University Medical Center
2019
Sacred Heart Hospital
2016
Konkuk University
2016
Catholic University of Korea
2016
St. Paul's Hospital
2016
Yeouido St. Mary's Hospital
2016
Korea University Medical Center
2016
Introduction: A low body mass index (BMI) is associated with increased mortality and health-related quality of life in patients COPD. The Asia-Pacific classification BMI has a lower cutoff for overweight obese categories compared to the World Health Organization (WHO) classification. present study assessed COPD among different according two systems: WHO Asia-Pacific. Patients methods: aged 40 years or older from Korean Subtype Study cohort were selected evaluation. We enrolled 1,462...
Neutrophils are key effectors in the host's immune response to sepsis. Excessive stimulation or dysregulated neutrophil functions believed be responsible for sepsis pathogenesis. However, mechanisms regulating functional plasticity of neutrophils during have not been fully determined.We investigated role autophagy patients with community-acquired pneumonia.Neutrophils were isolated from and stimulated phorbol 12-myristate 13-acetate (PMA). The levels reactive oxygen species generation,...
The Korea Chronic Obstructive Pulmonary Disorders Subgroup Study Team (Korea COPD team, KOCOSS) is a multicenter observational study that includes 956 patients (mean age 69.9 ± 7.8 years) who were enrolled from 45 tertiary and university-affiliated hospitals December 2011 to October 2014. initial evaluation for all included pulmonary function tests (PFT), 6-minute walk distance (6MWD), Assessment Test (CAT), modified Medical Research Council (mMRC) dyspnea scale, the COPD-specific version of...
Idiopathic pulmonary fibrosis (IPF) comprises an aggregate of mesenchymal cells. However, the cellular origin these phenotypes remains unclear. Transforming growth factor beta1 (TGF-beta1) has been known as main cytokine involved in pathogenesis IPF. We examined whether potent fibrogenic TGF-beta1 could induce epithelial-to-mesenchymal transition (EMT) human alveolar epithelial cell line, A549, and determined snail expression is associated with phenotypic changes observed A549 EMT was...
Interleukin-8 (IL-8) is a potent chemo-attractant cytokine responsible for neutrophil infiltration in lungs with idiopathic pulmonary fibrosis (IPF). The IL-8 protein and mRNA expression are increased the lung IPF. We evaluated effect of single nucleotide polymorphisms (SNPs) gene on risk IPF.One promoter (rs4073T>A) two intronic SNPs (rs2227307T>G rs2227306C>T) genes were genotyped 237 subjects IPF 456 normal controls. Logistic regression analysis was applied to evaluate association these...
Abstract Preventing exacerbation in chronic obstructive pulmonary disease (COPD) patients is crucial, but requires identification of the exacerbating factors. To date, no integrated analysis patient-derived and external factors has been reported. identify associated with COPD exacerbation, we collected data, including smoking status, lung function, assessment test scores, from 594 Korean subgroup study (KOCOSS), merged these data patients’ Health Insurance Review Assessment Service for...
<b>Objectives</b> To determine whether BCG vaccination protects against <i>Mycobacterium tuberculosis</i> infection as assessed by interferon γ release assays (IGRA) in children. <b>Design</b> Systematic review and meta-analysis. Searches of electronic databases 1950 to November 2013, checking reference lists, hand searching journals, contact with experts. <b>Setting</b> Community congregate settings households. <b>Inclusion criteria</b> Vaccinated unvaccinated children aged under 16 known...
Background: Patients with chronic obstructive pulmonary disease (COPD) often have poor health-related quality of life (HRQoL) that is disproportionate to their degree airflow limitation. This study evaluated the association between St George's Respiratory Questionnaire for COPD (SGRQ-C) score and forced expiratory volume in one second investigated factors responsible high SGRQ-C according severity Methods: Data from 1,264 patients were obtained Korean Subgroup Study (KOCOSS) cohort....
Purpose: Chronic obstructive pulmonary disease (COPD) is a respiratory characterized by chronic inflammation. Acute exacerbation of COPD (AECOPD) manifests as acute worsening symptoms and associated with high morbidity mortality. The aim the present study was to evaluate predictive value white blood count (WBC) its derived inflammatory biomarkers for AECOPD. Methods: From Korean Subgroup Study cohort, prospective multicenter observational study, 826 patients who had baseline complete (CBC)...
Abstract Introduction Mild hypoglycemia is associated with increased mortality in critically ill patients. However, data regarding the association between mild and patient outcomes among patients sepsis are limited. Methods Patients admitted to a medical ICU for sepsis, as defined by Surviving Sepsis Campaign guidelines, during 3-year period were enrolled retrospectively. Data on blood glucose (BG) control parameters collected. The primary outcome was relationship of (defined minimum BG 40...
The objective of this study was to assess the validity and reliability Korean version chronic obstructive pulmonary disease assessment test (CAT) Dyspnea-12 Questionnaire for patients with bronchiectasis or tuberculous destroyed lung.For 62 37 lung patients, 3 questionnaires including St. George's Respiratory Questionnaires (SGRQ), CAT, were obtained, in addition spirometric measurements. To CAT Dyspnea-12, correlation SGRQ evaluated. Cronbach's α coefficient calculated.The mean ages...
This study was conducted to investigate the association between chronic obstructive pulmonary disease (COPD) assessment test (CAT) and depression in COPD patients.The Korean versions of CAT patient health questionnaire-9 (PHQ-9) were used assess symptoms depressive disorder, respectively.In total, 803 patients with enrolled from 32 hospitals prevalence 23.8%.The score correlated well PHQ-9 (r = 0.631; P < 0.001) significantly associated presence (β ± standard error, 0.452 0.020; 0.001).There...
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Studies on the effectiveness of public health measures to prevent respiratory virus transmission in real-world settings are lacking. We investigated universal mask use and adherence other personal preventive changing viral infection patterns during coronavirus disease 2019 (COVID-19) pandemic.Data were extracted from South Korean National Respiratory Virus Sentinel Surveillance System. During COVID-19 pandemic, a cross-sectional survey was conducted. Additionally, number subway passengers...
Background: Comorbidities of chronic obstructive pulmonary disease (COPD) influence clinical characteristics and prognosis. Objectives: This study compared the exacerbation rate COPD according to presence depression or anxiety. Design: used data from The Korea Subgroup Study (KOCOSS) cohort, a nationwide prospective cohort 54 medical centers, between April 2012 2019. Methods: Depression anxiety were diagnosed with Beck Inventory Anxiety Inventory. Negative binomial regression analysis was...
Cigarette smoking is the most important risk factor for obstruction of airflow in chronic obstructive pulmonary disease (COPD). Matrix metalloproteinases (MMPs) or an imbalance between MMPs and their inhibitors, tissue inhibitors MMP (TIMPs), considered to play a role pathogenesis COPD. We investigated whether expression TIMP-1 associated with amount cigarette FEV1 value, lung parenchyma 26 subjects (6 non-smokers 20 smokers). First, we performed zymographic analysis identify profile MMPs,...
Immunoglobulin G subclass deficiency (IgGSCD) is a relatively common primary immunodeficiency disease (PI) in adults.The biological significance of IgGSCD patients with chronic airway diseases controversial.We conducted retrospective study to characterize the clinical features this population.This examined medical charts from 59 adult who had bronchial asthma or obstructive pulmonary (COPD) January 2007 December 2012.Subjects were classified according 10 warning signs developed by Jeffrey...
Background/Aims Cigarette smoking is the most common risk factor for chronic obstructive pulmonary disease (COPD). However, few studies of attitudes toward COPD smokers, group at developing this condition, have been conducted. The purpose study was to explore awareness and current smokers. Methods sample consisted 502 individuals aged 45 older from throughout Korea who smoked least 10 packs cigarettes per year. Telephone interviews using a structured questionnaire were conducted with...
Few studies have examined the natural course of early COPD. The aim this study was to observe COPD patients. We also aimed analyze medical utilization and costs for during a 6-year period.Patients with were selected from Korean National Health Nutrition Examination Survey (KNHANES) data. linked KNHANES data patients Insurance data.A total 2,397 enrolled between 2007 2012. mean forced expiratory volume in 1 second (FEV1) 78.6%, EuroQol five dimensions questionnaire (EQ-5D) index value 0.9. In...