A5034917040- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Pleural and Pulmonary Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Occupational and environmental lung diseases
- Tracheal and airway disorders
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antifungal resistance and susceptibility
- Lung Cancer Diagnosis and Treatment
- Infectious Diseases and Mycology
- Sepsis Diagnosis and Treatment
- Pericarditis and Cardiac Tamponade
- SARS-CoV-2 detection and testing
- Esophageal and GI Pathology
- Asthma and respiratory diseases
- Nosocomial Infections in ICU
- Abdominal vascular conditions and treatments
- Respiratory Support and Mechanisms
- Neonatal and Maternal Infections
- Vascular anomalies and interventions
Kangdong Sacred Heart Hospital
2016-2025
Hallym University
2016-2025
Fu Jen Catholic University
2021
National Cancer Center
2018
Inje University Busan Paik Hospital
2013-2017
Jeju National University Hospital
2016
Inje University
2014-2015
Sungkyunkwan University
2000-2014
Samsung Medical Center
2000-2014
Neutrophils are key effectors in the host's immune response to sepsis. Excessive stimulation or dysregulated neutrophil functions believed be responsible for sepsis pathogenesis. However, mechanisms regulating functional plasticity of neutrophils during have not been fully determined.We investigated role autophagy patients with community-acquired pneumonia.Neutrophils were isolated from and stimulated phorbol 12-myristate 13-acetate (PMA). The levels reactive oxygen species generation,...
Abstract Disparities exist between sexes regarding tuberculosis (TB) incidence, as well disease severity and outcome. Using a nationwide TB registry database, we explored the impact of sex age on extrapulmonary (EPTB) among all enrolled patients by (1) calculating female proportion for every category according to TB-affected locations, (2) proportions EPTB stratified age, (3) conducting multivariable analysis examine likelihood, (4) assessing odds compared male reference in category....
Poor nutrition increases disease severity and mortality in patients with tuberculosis (TB). There are gaps our understanding of the effects being underweight or overweight on TB relation to sex.We generated a nationwide registry database assessed body mass index (BMI) pulmonary TB. The cause death was further classified as TB-related non-TB-related deaths. First, logistic regression analysis performed assess association between BMI (a continuous variable) mortality, subgroup analyses...
Patients with tuberculosis and diabetes have a higher risk of unfavourable anti-tuberculosis treatment outcomes. In the present study, we aimed to evaluate effects various statuses on outcomes patients pulmonary tuberculosis.
The purpose of this study was to compare the turnaround time for liquid culturing and primary anti-tuberculous drug susceptibility testing (DST) performed using mycobacteria growth indicator tube (MGIT) 960 system (Becton Dickinson, USA) with that conventional DST (by absolute concentration method) solid culture medium determine concordance rates results obtained these 2 methods.In retrospective study, we compared times from receiving request mycobacterial reporting before after introduction...
The national Public-Private Mix (PPM) tuberculosis (TB) control project provides for the comprehensive management of TB patients at private hospitals in South Korea. Surveillance and monitoring under PPM are essential toward achieving elimination goals.TB is a nationally notifiable disease Korea monitored using surveillance system. Centers Disease Control Prevention quarterly generates indicators management, used to evaluate activities by central steering committee project. Based on...
Tuberculosis (TB) is a major cause of ill health and one the leading causes death worldwide. The first step in developing strategies to reduce TB mortality identify direct patients with risk factors for each cause.Data on systemically collected from National Surveillance System South Korea January 2019 December 2020 were included this study. We analyzed clinical characteristics associated non-TB-related deaths, including TB-related symptoms, comorbidities, radiographic microbiological...
Background/Aims We evaluated the trend in rates of drug-resistant tuberculosis (TB) over time, as well difference drug-resistance pattern between pulmonary (PTB) and extrapulmonary (EPTB) at a private referral center South Korea. Methods All patients with culture-confirmed TB from 2006 to 2013 were included. Results In total, 1,745 included: 1,431 (82.0%) new cases, 314 (18.0%) cases treated previously; 1,610 (92.3%) diagnosed PTB, 135 (7.7%) EPTB. Multidrug-resistant (MDR) extensively (XDR)...
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic caused disruptions to healthcare systems and endangered the control prevention of tuberculosis (TB). We investigated nationwide effects COVID-19 on national Public-Private Mix (PPM) TB project in Korea, using monitoring indicators from Korean PPM database. METHODS: database includes data patients registered at hospitals throughout country. Data six for active cases updated between July June 2020 were collected. each cohort country...
Isolation of M. tuberculosis (MTB) is required in cases Tuberculous pleural effusion (TBPE) for confirming diagnosis and successful therapy based on drug sensitivity test. Several studies have focused predictors MTB culture positivity TBPE. However, the clinical role loculated TBPE as a predictor cultivation from remains unclear. The aim this study was to examine possible including loculation TBPE.We retrospectively examined associations between clinical, radiological, microbiological,...
Colistin alone may not be sufficient for treating carbapenem-resistant Acinetobacter baumannii (CRAB); thus, efforts are needed to increase treatment success rates. We compared the effects of colistin plus carbapenem therapy versus monotherapy in pneumonia caused by CRAB and attempted identify specific populations or factors that could benefit from combination therapy.We retrospectively collected data on cases pneumonia. The patients were divided into groups. primary outcome was 14-day...
The coronavirus disease 2019 (COVID-19) pandemic caused disruptions to healthcare systems, consequently endangering tuberculosis (TB) control. We investigated delays in TB treatment among notified patients during the first wave of COVID-19 Korea. systemically collected and analyzed data from Korea cohort database January May 2020. Groups were categorized as 'before-pandemic' 'during-pandemic' based on notification period. Presentation delay was defined period between initial onset symptoms...
Background: The delta neutrophil index (DNI) represents the immature granulocyte fraction and is determined by subtracting of mature polymorphonuclear leucocytes from sum myeloperoxidase-reactive cells. DNI has been proposed as a useful prognostic marker sepsis. This study evaluated clinical utility predictive in patients with pneumonia-induced sepsis intensive care unit (ICU). Materials & Methods: We conducted retrospective who were admitted to Kangdong Sacred Heart Hospital’s...
The increasing incidence and mortality rates of tuberculosis among older individuals who suffer from multiple morbidities are vulnerable to malnutrition major obstacles efforts eradicate in the Republic Korea. Herein, we identified factors associated with during anti-tuberculosis treatment patients pulmonary tuberculosis. We conducted a case-control study extracted data database multi-center prospective observational cohort Among participants rifampicin-susceptible tuberculosis, survival...
Background: The delta neutrophil index (DNI) represents the immature granulocyte fraction and is determined by subtracting of mature polymorphonuclear leucocytes from sum myeloperoxidase-reactive cells. DNI has been proposed as a useful prognostic marker for sepsis. This study evaluated clinical utility predictive in patients with pneumonia-induced sepsis intensive care unit (ICU). Methods: We conducted retrospective who were admitted to Kangdong Sacred Heart Hospital’s medical ICUs July...
Screening patients with asymptomatic active tuberculosis (TB) is crucial as they can transmit the disease. Identifying risk factors for transmission essential targeted screening. Understanding how infectiousness of TB affects disease outcomes developing strategies to control spread. We analyzed national Korean cohort data determine associated and clinical in pulmonary TB. The primary outcome was a factor transmission, while secondary mortality stratified by risk. Among 20 455 TB, 7434...
Thyroid transcription factor (TTF)-1 expression is a diagnostic marker and good prognostic indicator for lung adenocarcinoma. However, its ability might be due to epidermal growth receptor (EGFR)-sensitizing mutations as shown by the positive correlation between TTF-1 EGFR mutations. We explored impact of according EGFR-sensitizing mutation status in adenocarcinoma patients.We conducted retrospective cohort study patients with stage IV Data were extracted from cancer registry Hallym...
Malnutrition is closely associated with pulmonary tuberculosis (PTB). However, changes before and after treatment remain unclear. We aimed to investigate the longitudinal in nutritional status from follow-up of TB 215 PTB cases South Korea. First, we evaluated trend body mass index (BMI) time diagnosis a 2-year follow-up. Second, compared BMIs our 5694 controls who participated Korean national survey treatment. During period, BMI smear-positive group (n = 72) significantly increased that...
In tuberculosis (TB) treatment, adverse drug reactions (ADRs) can interrupt treatment and decrease the quality of life (QoL). We aimed to prospectively investigate incidence ADRs first-line anti-TB drugs related outcomes QoL.Adult patients with TB who had been treated in five Korean hospitals were enrolled. ADR questionnaire surveys blood tests performed four times serially, QoL was assessed on fourth week (±2 weeks).Of 410 enrolled (males, 62%; mean age, 52.1 ± 18.1 years [those aged ≥65...
Abstract Background Drug-induced liver injury (DILI) may lead to the discontinuation of antituberculosis (anti-TB) treatment (ATT). Some studies have suggested that metabolic disorders increase risk DILI during ATT. This study aimed identify factors for DILI, particularly disorders, Methods A multicenter prospective observational cohort evaluate adverse events ATT was conducted in Korea from 2019 2021. Drug-susceptible patients with TB who had been treated standard 6 months were included....
ABSTRACT Background and objective Matrix degradation is a key feature of chronic obstructive pulmonary disease ( COPD ). Desmosine isodesmosine (desmosines) are excreted in urine following matrix degradation. The main purpose this study was to investigate the association between computed tomography CT ) emphysema indices urinary desmosines patients with . Methods A total 152 subjects were selected from Korean Obstructive Lung Disease cohort. Their samples assayed for using liquid...
Although prevalence of Mycobacterium avium complex pulmonary disease (MAC-PD) is increasing, limited data are available regarding vulnerability to (MAC) infections. To understand the pathobiology interaction between MAC and host-immunity, it important characteristics for circulating T cells in terms immunological phenotype functional correlates MAC-PD. We aimed characterize immunophenotype, cytokine profile, immune inhibitory receptors CD4+ MAC-PD patients. enrolled 71 20 control...
<h3>BACKGROUND:</h3> The use of high-flow nasal cannula (HFNC) is rapidly increasing without clear indications, creating the potential for overuse or misuse and accompanying risk adverse events. purpose this study was to determine factors associated with HFNC failure by examining current clinical practice HFNC. <h3>METHODS:</h3> From July 1, 2017, June 30, 2018, in 5 university-affiliated hospitals Republic Korea, a total 1,161 admitted adult subjects who had administered were...