A5063736270- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Air Quality and Health Impacts
- Lung Cancer Treatments and Mutations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Occupational and environmental lung diseases
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Climate Change and Health Impacts
- Global Health Workforce Issues
- Pulmonary Hypertension Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Global Health and Surgery
- Pleural and Pulmonary Diseases
- Colorectal Cancer Treatments and Studies
- Occupational exposure and asthma
- Innovations in Medical Education
- Eosinophilic Disorders and Syndromes
- Infectious Diseases and Tuberculosis
- Pediatric health and respiratory diseases
- Air Quality Monitoring and Forecasting
- Insects and Parasite Interactions
- Parasitic Infections and Diagnostics
- Respiratory Support and Mechanisms
- MicroRNA in disease regulation
- Respiratory viral infections research
Gachon University Gil Medical Center
2014-2025
Gachon University
2014-2025
Deleted Institution
2009-2024
ORCID
2020
Pulmonary and Allergy Associates
2019
Instituto de Estudos Avançados da Universidade de São Paulo
2013
Korea Health Promotion Institute
2013
Inje University
2013
Charles R. Drew University of Medicine and Science
2011
<h3>BACKGROUND:</h3> The N95 filtering facepiece respirator (FFR) is the most popular individual protective device to reduce exposure particulate matter. However, concerns have been raised with regard its use because it can increase respiratory resistance and dead space. Therefore, this study assessed safety of in patients COPD air-flow limitation. <h3>METHODS:</h3> This prospective was performed at a tertiary hospital enrolled 97 subjects COPD. were monitored for symptoms physiologic...
Genexol-PM is a Cremorphor EL (CrEL)-free polymeric micelle formulation of paclitaxel that allows higher-dose administration with less hypersensitivity. This study was designed to evaluate the efficacy and safety gemcitabine combination in advanced non-small cell lung cancer patients as first-line treatment. prospective, single-arm, single-center phase II study. Patients NSCLC received at 230 mg/m2 on day 1 1,000 8 3-week cycle. Six cycles chemotherapy were planned unless there disease...
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective treatment. The epithelial-mesenchymal transition (EMT) critical stage during the development of fibrosis. To assess effect sulforaphane (SFN) on EMT using an in vitro transforming growth factor (TGF)-β1-induced model vivo bleomycin (BLM)-induced model. In studies, cell viability, cytotoxicity were measured Cell Counting Kit-8. functional TGF-β1-induced assessed western blotting quantitative real-time...
Objective: Dust generating events frequently produce ambient dust particles that are less than 10 µm in diameter, and these have been linked to adverse effects the general population. However, evidence linking on airways of asthmatic individuals is limited. The objective this study was investigate possible Asian respiratory functions symptoms subjects with bronchial asthma. Methodology: From March June 2002, were enrolled who had diagnosed as having asthma by challenge or their...
Several recent clinical trials reported that intralymphatic immunotherapy (ILIT) for some allergens, such as cat dander and pollen, induce tolerance more rapidly than conventional subcutaneous or sublingual immunotherapy, have a comparable duration of effect after only 3 injections, do not provoke serious local systemic reactions.However, the efficacy safety ILIT are using Dermatophagoides farinae (Df), pteronyssinus (Dp), dog, which indoor allergens commonly found globally, need to be...
Patients with tuberculosis and diabetes have a higher risk of unfavourable anti-tuberculosis treatment outcomes. In the present study, we aimed to evaluate effects various statuses on outcomes patients pulmonary tuberculosis.
Particulate matter (PM) is a type of air pollutant that induces adverse health effects, including acute exacerbation chronic obstructive pulmonary disease (COPD). However, the effects co-exposure to PM and cigarette smoke extract (CSE) on bronchial epithelial cells remain unknown. This study investigated cytotoxic pro-inflammatory combined exposure CSE cells, assessed potential antioxidants inhibit CSE/PM-induced oxidative stress inflammation. Exposure or induced cytotoxicity, inflammation,...
Abstract: A new quinolone, zabofloxacin, has now been developed; hence, a non-inferiority trial is needed to compare this compound with another widely used quinolone examine its efficacy and safety for the treatment of chronic obstructive pulmonary disease (COPD) exacerbations. This was prospective, multicenter, double-blind, double-dummy, randomized, controlled, parallel-group, Phase III, clinical designed oral zabofloxacin (367 mg once daily 5 days) moxifloxacin (400 7 patients COPD...
Abstract Epithelial–mesenchymal transition (EMT), a process by which epithelial cells undergo phenotypic conversion that leads to myofibroblast formation, plays crucial role in the progression of idiopathic pulmonary fibrosis (IPF). Recently, it was revealed hypoxia promotes alveolar EMT and histone deacetylases (HDACs) are abnormally overexpressed lung tissues IPF patients. In this study, we showed HDAC3 regulated markers via AKT pathway during inhibition expression small interfering RNA...
Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% cases. Although generally well tolerated, anaphylactic reactions to this drug have been reported a few We report here 46-year-old Korean female paragonimiasis, presumed due Paragonimus westermani, who displayed allergic reaction and resistance triclabendazole treatment. The patient was following rapid desensitization procedure....
Evidence suggests that diabetes mellitus (DM) is associated with idiopathic pulmonary fibrosis (IPF). According to the new IPF guidelines, high-resolution computed tomography (HRCT) an essential means of diagnosing IPF. We investigated relationship between and DM in patients treated 2003 2007. Newly diagnosed large university teaching hospitals Korea were enrolled from January December retrospectively analyzed 1,685 using interstitial lung disease (ILD) registry. In total, 299 (17.8%) also...
Background: This study analyzed the status of community-based practice in public healthcare institutions Korean medical schools and identified related needs. Methods: We conducted an online cross-sectional survey which 32 40 (80.0%) participated between March April 2023. developed questionnaire items aimed at ascertaining perceptions response data using frequency analysis, Mann-Whitney U test, content analysis with word clouds.Results: Of analyzed, 23 (71.9%) offered practical courses,...
Objective: To examine the status of early clinical exposure (ECE) programs in Korean medical schools and to determine educational needs for ECE undergraduate education. Methods: In this cross-sectional study, 30 education experts 65 professors from across Korea were surveyed about ECE. This survey was conducted between January March 2024 using Google Forms, collected data analyzed frequency analysis. Results: Out participating schools, 70% had implemented programs. most required courses...
The aim of this study was to develop guidelines for the prevention and management particulate matter (PM)/Asian dust particle (ADP)-induced adverse effects in patients with pulmonary diseases. guideline development committee reviewed literature on matter, ADP, In adults, exposure a diameter 10 µm or less (PM10) induces decline lung function. PM confers an increased risk cancer, PM10 is associated hospital admission mortality due chronic obstructive disease. ADP emergency room visits...
Background Combined pulmonary fibrosis and emphysema (CPFE) have different function tests (PFTs) outcomes than idiopathic (IPF). The intention of this study was to identify unknown differences between CPFE IPF by a retrospective comparison clinical data including baseline annual changes in function, comorbidities, laboratory findings, characteristics cause hospitalization. Methods This retrospectively enrolled patients with who had undergone PFTs once or several times per year during...
Nail toxicity is one of the most frequent non-hematologic toxicities docetaxel and often deteriorates patients' quality life, leading to treatment discontinuation. To define incidence nail change as well its association with specific risk factors, we prospectively investigated data 84 consecutive patients advanced non-small cell lung cancer who received first-line docetaxel/cisplatin combination chemotherapy. Chemotherapy-naïve were treated docetaxel, either 3-weekly or weekly, in cisplatin....
Background Recent studies show that mitophagy, the autophagy-dependent turnover of mitochondria, mediates pulmonary epithelial cell death in response to cigarette smoke extract (CSE) exposure and contributes development emphysema vivo during chronic (CS) exposure, although underlying mechanisms remain unclear. Methods In this study, we investigated role mitophagy regulation CSE-exposed lung bronchial (Beas-2B) death. We also a phosphodiesterase 4 inhibitor, roflumilast, CSE-induced...