A5103044274- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adrenal and Paraganglionic Tumors
- Injury Epidemiology and Prevention
- Pituitary Gland Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Bacterial Identification and Susceptibility Testing
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
- COVID-19 epidemiological studies
- Head and Neck Anomalies
- Probiotics and Fermented Foods
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Respiratory and Cough-Related Research
- Infection Control and Ventilation
- Mycobacterium research and diagnosis
Hallym University Dongtan Sacred Heart Hospital
2014-2024
Hallym University
2007-2016
Hallym University Medical Center
2013-2014
Hangang Sacred Heart Hospital
2010-2013
Background: From May to July 2015, the Republic of Korea experienced largest outbreak Middle East respiratory syndrome (MERS) outside Arabian Peninsula.A total 186 patients, including 36 deaths, had been diagnosed with MERS-coronavirus (MERS-CoV) infection as September 30th, 2015.Materials and Methods: We obtained information patients who were confirmed have MERS-CoV infection.MERS-CoV was using real-time reverse-transcriptase polymerase chain reaction assay. Results:The median age 55 years...
Colistin is increasingly used as a salvage therapy for nosocomial infections caused by multidrug-resistant Gram-negative bacteria such Pseudomonas aeruginosa and Acinetobacter baumannii. However, the available pharmacokinetic (PK) data colistin are limited to guide dosing. The aim of this study was develop population PK model identify optimal dosage regimens burn patients. Fifty patients with burns ranging from 4% 85% total body surface area who had been treated colistimethate sodium (CMS)...
ABSTRACT Piperacillin in combination with tazobactam, a β-lactamase inhibitor, is commonly used intravenous antibiotic for the empirical treatment of infection intensive care patients, including burn patients. The purpose this study was to develop population pharmacokinetic (PK) model piperacillin patients and predict probability target attainment (PTA) using MICs concentrations simulated from PK model. Fifty treated piperacillin-tazobactam were enrolled. Piperacillin-tazobactam administered...
Background: Burn wounds lack normal barriers that protect against pathogenic bacteria, and burn patients are easily colonized infected by Staphylococcus aureus.Toxic shock syndrome (TSS) is a rare but fatal disease caused S. aureus.A of detectable antibodies to TSS toxin-1 (TSST-1) in serum indicates susceptibility TSS.Methods: A total 207 (169 men 38 women; median age, 42.5 yr) admitted center Korea were enrolled this study.The antibody titer TSST-1 was measured sandwich ELISA.S. aureus...
Carbapenem-resistant Enterobacteriaceae (CRE) pose a global health threat; however, there is still limited understanding of the risk factors and underlying mechanisms CRE colonization in gut microbiome. We conducted matched case-control study involving 282 intensive care unit patients to analyze influencing covariates on colonization. Subsequently, their effects microbiome were analyzed subset 98 (47 carriers 51 non-CRE carriers) using whole metagenome sequences. The concomitant use proton...
Reliable results for serological positivity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody after the second dose of AstraZeneca (AZ) vaccination are important estimate real efficacy vaccination. We evaluated rates and changes in semiquantitative titers before first ChAdOx1 nCoV-19 vaccinations using five SARS-CoV-2 assays, including two surrogate virus neutralization tests. A total 674 serum samples were obtained from 228 participants during three blood sampling...
Fire smoke contains toxic gases and numerous chemical compounds produced by incomplete combustion, may cause injury to the airways. Increased airway reactivity, as well a decrease in lung function, has been reported sequela of inhalation injury. This study was undertaken assess functions early phase patients with damage from fires.A total 15 fire (fire group) subjects chronic cough but no previous history disease (chronic were enrolled. For diagnosis injury, we performed bronchoscopy,...
We report a rare synchronous presentation of primary lung cancer and adrenal pheochromocytoma. A 59-year-old woman was diagnosed with right upper lobe non-small cell carcinoma measuring 2.8 cm gland mass 3.5 cm, which displayed increased metabolic activity on 18F-fluorodeoxyglucose positron emission tomography-computed tomography. The lesion revealed to be asymptomatic. patient underwent adrenalectomy histological examination Ten days later, lobectomy performed for cancer. This case...
연구배경: 원내 폐렴의 적절한 항균제 치료를 위해서는 원발 병소에서의 원인균 규명과 항균제에 대한 내성 유무 확인이 필수적이다. 본 연구는 폐렴이 의심되는 경우 기관지내시경을 통한 정량적 기관지폐포 세척술(bronchoalveolar lavage, BAL) 배양검사를 시행하여 빈번하게 분리되는 균주와 이들의 현황을 알아보고자 하였다. 방법: 2004년 1월부터 2006년 6월까지 한림의대 한강성심병원 화상 중환자실과 비화상 중환자실에서 폐 침윤의 원인규명 위해 BAL 검사를 시행하였다. 104 CFU/mL 이상의 균주가 분리되면 양성으로 판정하였다. 결과: 검사 결과 화상중환자실 27예(77.1%), 비화상중환자실 22예(59.4%)에서 배양 양성이었다. 주요 균주는 S. aureus, Acinetobacter species 및 P. aeruginosa였다. 화상중환자실에서 분리된 aureus의 전부 MRSA(100%)였으며, 비화상중환자실에서는 71.4%가 MRSA로...
We compared four combinations of nasopharyngeal swabs and transport media for their ability to transfer recover viruses under different storage conditions.Each swab was immersed in culture supernatants influenza A virus (IAV), respiratory syncytial virus, adenovirus, placed medium, stored at -20℃, +4℃, +20 25℃, +37℃ 5 days. On each day, real-time PCR were performed virus.All samples conditions showed positive results up days using both PCR. Real-time that 4℃, 20 - 25℃ within two cycle...