A5073362619- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Central Venous Catheters and Hemodialysis
- Renal and Vascular Pathologies
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Metabolism and Genetic Disorders
- Organ Transplantation Techniques and Outcomes
- Renin-Angiotensin System Studies
- GDF15 and Related Biomarkers
- Vascular Procedures and Complications
- Electrolyte and hormonal disorders
- Erythropoietin and Anemia Treatment
- Body Composition Measurement Techniques
- Renal Transplantation Outcomes and Treatments
- Chemotherapy-induced organ toxicity mitigation
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Fatty Acid Research and Health
- Thermal Regulation in Medicine
- Vasculitis and related conditions
- Pharmacological Effects and Toxicity Studies
Chungnam National University Hospital
2016-2025
Seoul National University
2005-2024
Seoul National University Bundang Hospital
2014-2024
Daejeon University
2024
Chungnam National University
2009-2023
Hospital Británico de Buenos Aires
2022
ORCID
2020
Yonsei University
2016
New Generation University College
2015
Dapagliflozin, a new type of drug used to treat diabetes mellitus (DM), is sodium/glucose cotransporter 2 (SGLT2) inhibitor. Although some studies showed that SGLT2 inhibition attenuated reactive oxygen generation in diabetic kidney the role unknown. We evaluated whether SLT2 has renoprotective effects ischemia-reperfusion (IR) models. dapagliflozin reduces renal damage IR mice model. In addition, hypoxic HK2 cells were treated with or without inhibitor investigate cell survival, apoptosis...
<i>Background/Aims:</i> Depending on the specific definition, acute kidney injury (AKI) occurs in 7–40% of patients undergoing cardiac surgery. Even small changes serum creatinine (SCr) levels are associated with increased mortality after However, there no current methods for preventing AKI Erythropoietin (EPO) has been shown to elicit tissue-protective effects various experimental models. In this pilot trial, we evaluated effectiveness EPO prevention coronary artery bypass...
Sildenafil was the first selective inhibitor of phosphodiesterase-5 (PDE5) to be widely used for treating erectile dysfunction. Many recent studies have investigated cardioprotective role sildenafil in animal models. We evaluated protective effects experimental renal ischemia-reperfusion (IR) injury two studies. In study 1, male Sprague-Dawley rats were divided into four groups: sham, sildenafil-treated vehicle-treated IR, and IR groups. 2, we PD98059 (ERK inhibitor)+sildenafil-treated rats....
Background and objectives The notion that oral intestinal sorbent AST-120 slows renal disease progression has not been evaluated thoroughly. In this study, we investigated the long-term effect of on (doubling serum creatinine, eGFR decrease >50%, or initiation RRT) in patients with advanced CKD. Design, setting, participants, & measurements We prospectively recruited 579 (CKD stage 3 4) from 11 medical centers Korea March 4, 2009 to August 31, 2010 randomized them into an arm a control arm....
Bioimpedance analysis (BIA) helps measuring the constituents of body noninvasively. Prior studies suggest that BIA-guided fluid assessment to predict survival in dialysis patients. We aimed evaluate clinical usefulness BIA for predicting rate hemodialysis patients Korea.We conducted a single-center retrospective study. All were diagnosed with end-stage renal disorder and started maintenance between June 2009 April 2014. was performed within 1(st) week from start hemodialysis. The classified...
<i>Background:</i> The phospholipase A<sub>2</sub> receptor (PLA2R) is a major antigen found in patients with idiopathic membranous nephropathy (MN). relationship of genetic polymorphisms PLA2R the susceptibility and clinical outcomes this disease unknown. <i>Methods:</i> We studied 199 MN followed up for 3.7 ± 3.2 years. enrolled 33 secondary 356 subjects normal blood pressure no proteinuria. single nucleotide (SNPs) were genotyped....
Warfarin-related nephropathy (WRN) is a recently described disease entity, in which excessive warfarinization (international normalized ratio (INR) >3.0) causes acute kidney injury. Previous reports regarding WRN included few Asian patients who might have differed from the western terms of genetic and environmental factors.During period March 2003 to December 2011, data about total 1297 had serum creatinine (sCr) level measured within 1 week after INR >3.0 6 months before was analyzed...
Abstract Metformin is the primary treatment for type 2 diabetes mellitus (T2DM) due to its effectiveness in improving clinical outcomes patients with preserved renal function, however, evidence on of metformin various functions lacking. We performed a retrospective, multicenter, observational study used data T2DM obtained from three tertiary hospitals’ databases. Patients given within run-in periods and at least one additional prescription formed cohort. A control cohort comprised those...
Renin-angiotensin system activation is involved in inflammation and fibrosis the kidney. Aliskiren, a direct renin inhibitor, decreases renin-angiotensin activation, including plasma activity angiotensin II, but increases prorenin level, which may promote renal tissue. Thus, we evaluated whether inhibiting by aliskiren would decrease mouse model of unilateral ureteral obstruction.Ten-week-old male C57BL/6 mice (Samtako, Kyoung Gi-Do, Korea) weighing 30 to 33 gm were divided into 4 groups,...
Introduction In peritoneal dialysis (PD) patients, volume overload is related to cardiac dysfunction and mortality, while intravascular depletion associated with a rapid decline in the residual renal function (RRF). This study sought determine clinical usefulness of bioimpedance spectroscopy (BIS)-guided fluid management for preserving RRF PD patients. Subjects methods multicenter, prospective, open-label that was conducted over 1-year period (NCT01887262). Non-anuric (urine > 500 mL/day)...
Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.This disease, which quickly spreading worldwide, has high potential for infection and causes rapid progression of lung lesions, resulting in a mortality rate.This study aimed to investigate the effects SARS-CoV-2 on renal function patients with COVID-19.Methods: From February 21 April 24, 2020, 66 diagnosed COVID-19 at Chungnam National University Hospital were...
For reducing the high mortality rate of severe acute kidney injury (AKI) patients initiating continuous renal replacement therapy (CRRT), diagnosing sepsis and predicting prognosis are essential. However, with reduced function, biomarkers for unclear. This study aimed to assess whether C-reactive protein (CRP), procalcitonin, presepsin could be used diagnose predict in impaired function CRRT. was a single-center, retrospective involving 127 who initiated Patients were divided into non-sepsis...
Objectives: This study aimed to classify fasting blood glucose (FBG) trajectories by sex and examine their associations with the risk of chronic kidney disease (CKD). Methods: Using data from National Health Insurance Service-National Sample Cohort in Korea, participants aged 40 years above, without CKD or diabetes mellitus (DM), were followed 2002 2009. Based on FBG trajectories, categorized into two classes stratified sex. incidence rates analyzed according these impact additional factors...
ABSTRACT Aim Efepoetin alfa, a novel long‐acting erythropoietin (EPO)‐hybrid Fc fusion protein, represents promising erythropoiesis‐stimulating agent (ESA) for addressing anaemia in chronic kidney disease (CKD) patients. This Phase 3 trial was to assess the efficacy and tolerability of subcutaneous efepoetin alfa comparison methoxy polyethylene glycol‐epoetin beta stage or 4 CKD Methods A randomised, multicentre, open‐label enrolled 391 Subjects underwent 20‐week correction period followed...
Abstract Background Elevated serum level of fibroblast growth factor-23 (FGF23) is associated with adverse outcomes in dialyzed patients. Objectives The CUPID study compared the efficacy a cinacalcet-based regimen conventional care (vitamin D and P binders) for achieving stringent NKF-K/DOQI targets peritoneal dialysis (PD) Additionally, we analyzed change FGF23 levels between two treatments to explore cinacalcet effect lowering FGF23. Design Multicenter, open-labeled, randomized controlled...
Kidney transplantation is an effective renal replacement therapy for patients with end-stage disease (ESRD). In this study, we assessed the impact of baseline characteristics and comorbidities ESRD on probability deceased donor kidney (DDKT) evaluated morbidity mortality during time spent waiting.The study population consisted 544 waiting list DDKT at Chungnam National University Hospital in South Korea between February 2000 October 2015. The were observed from date registration to...
Renal disease associated with type 2 diabetes mellitus (T2DM) has become the leading cause of chronic kidney (CKD). ultrasonography is an imaging examination required in work-up renal disease. This study aimed to identify differences ultrasonographic findings between patients and without DM, evaluate relationship ultrasound prognosis DM. A total 252 who underwent at Chungnam National University Hospital were included. Kidney progression was defined as a ≥10% decline annual estimated...
To characterize the association between chronic kidney disease (CKD), mortality, severity of coronary artery (CAD), treatment modality CAD, and type stents among patients undergoing angiography (CAG), we retrospectively reviewed electronic medical records who underwent CAG at Seoul National University Bundang Hospital in Korea May 2003 January 2006. CKD was staged using an estimated glomerular filtration rate (eGFR) from creatinine value prior to CAG. There were 3,637 included. The presence...
Erythropoietin was recently shown to exert important cytoprotective and anti-apoptotic effects in injury models of the brain, heart kidney. We examined whether erythropoietin also attenuates renal a rat model unilateral ureteral obstruction via anti-inflammatory actions.We divided Sprague-Dawley rats (Korea Research Institute Bioscience Biotechnology, Daejeon, Korea) into 4 groups, including 1-vehicle treated with sham operation, 2-vehicle for 3 days, 3-erythropoietin treatment operation...
The presence of tubuloreticular inclusions (TRIs) in endothelial cells (ECs) always evokes suspicion an association with underlying viral infections or autoimmune diseases. However, other diseases can be associated TRI expression. Since identification the disease is primary consideration for management glomerulonephritis (GN), it important to clarify clinical significance expression.The authors studied 104 renal biopsy cases having TRI. They investigated their clinicopathological profiles...
Both hyponatremia and acute kidney injury (AKI) are common harmful in hospitalized patients. However, their combined effects on patient mortality have been little studied.We retrospectively enrolled 19191 adult patients who were admitted for 1 year. Pre-existing was defined as a serum sodium level < 135 mmol/L the first measurement of admission. AKI rise creatinine by ≥ 26.5 μmol/L or 1.5 times baseline value during hospital stay.The prevalence pre-existing 8.2%. During median 6.0 days stay,...