A5081668121- Renal Diseases and Glomerulopathies
- Ovarian cancer diagnosis and treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vasculitis and related conditions
- HER2/EGFR in Cancer Research
- Chronic Kidney Disease and Diabetes
- Monoclonal and Polyclonal Antibodies Research
- Acute Kidney Injury Research
- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Pregnancy and preeclampsia studies
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Renal Transplantation Outcomes and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Cervical Cancer and HPV Research
- Prenatal Screening and Diagnostics
- Chromatin Remodeling and Cancer
- Pleural and Pulmonary Diseases
- Neuroendocrine Tumor Research Advances
- Autoimmune Bullous Skin Diseases
- Uterine Myomas and Treatments
- Nutrition, Health and Food Behavior
- Tuberous Sclerosis Complex Research
Chungnam National University
2013-2024
Chungnam National University Hospital
2015-2024
Seoul National University
2018
Hackensack University Medical Center
2014
Ulsan College
2008
University of Ulsan
2008
Asan Medical Center
2008
Catholic University of Korea
2003
Washington University Medical Center
1990
George Washington University
1990
The purpose of the present study was to investigate frequency BRAF mutations in human papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) evaluate association mutation with clinicopathological features both these disorders. A total 51 PTC no HT, 28 HT 27 were evaluated using DNA extracted from paraffin‐embedded specimens. analyzed by direct sequencing polymerase chain reaction (PCR)‐amplified exon 15. missense at codon 599 (T1796A) 46 (90%) 18 (64%) four (14%) PTC, zero PTC....
Insulin-like growth factor 1 receptor (IGF-1R) is commonly expressed in primary breast cancers. Understanding the role of IGF-1R signaling different subtypes cancer important because each subtype has a outcome and requires treatment modalities. However, precise biological significance expression cells still unclear. In this study, we examined molecular cancer. The effects on survival rates outcomes were also examined.
Summary: Eleven cases of tubal metaplasia the uterine cervix are presented. These characterized histologically by architecturally normal endocervical glands containing ciliated or clear cells, nonciliated and intercalary peg resembling mucosa. Transitions from to epithelium within a single gland frequently seen. Eight these involved near squamocolumnar junction, six showed along overlying surface epithelium. Superficial (in one case) deep were involved. No correlation was found between...
Erythropoietin was recently shown to exert important cytoprotective and anti-apoptotic effects in injury models of the brain, heart kidney. We examined whether erythropoietin also attenuates renal a rat model unilateral ureteral obstruction via anti-inflammatory actions.We divided Sprague-Dawley rats (Korea Research Institute Bioscience Biotechnology, Daejeon, Korea) into 4 groups, including 1-vehicle treated with sham operation, 2-vehicle for 3 days, 3-erythropoietin treatment operation...
The presence of tubuloreticular inclusions (TRIs) in endothelial cells (ECs) always evokes suspicion an association with underlying viral infections or autoimmune diseases. However, other diseases can be associated TRI expression. Since identification the disease is primary consideration for management glomerulonephritis (GN), it important to clarify clinical significance expression.The authors studied 104 renal biopsy cases having TRI. They investigated their clinicopathological profiles...
Amplification of the human epidermal growth factor receptor 2 (HER2) gene occurs in 18% to 20% breast cancers, and it is recognized as a prognostic predictive marker. We investigated HER2 status Korean cancer by immunohistochemistry (IHC) silver-enhanced situ hybridization (SISH), first step toward building nationwide quality assurance program for testing.A total 1,198 carcinoma samples were collected from six institutions IHC SISH performed using tissue microarrays central laboratories. The...
Nafamostat mesilate (NM) is a serine protease inhibitor with anticoagulant and anti-inflammatory effects. NM has been used in Asia for anticoagulation during extracorporeal circulation patients undergoing continuous renal replacement therapy extra corporeal membrane oxygenation. Oxidative stress an independent risk factor atherosclerotic vascular disease associated endothelial function. We investigated whether could inhibit dysfunction induced by tumor necrosis factor-α (TNF-α). Human...
Recent studies have implicated mitochondrial disruption in podocyte dysfunction, which is a characteristic feature of primary and diabetic glomerular diseases. However, the mechanisms by dysfunction podocytes affects renal diseases are currently unknown. To investigate role oxidative phosphorylation (OxPhos) function was examined mice carrying loss mutation gene encoding CR6-interacting factor-1 (CRIF1), essential for intramitochondrial production subsequent insertion OxPhos polypeptides...
Fabrazyme has been widely used for treatment of Fabry disease since its approval by the U.S. Food and Drug Administration in 2003. This study was undertaken to assess short-term efficacy safety enzyme replacement therapy (ERT) Korea. Eight male patients three female symptomatic carriers aged 13 48 yr were included. administered intravenous infusion at a dose 1 mg/kg every 2 weeks. Plasma urine globotriaosylceramide (GL-3) levels, serum creatinine, creatinine clearance, 24-hr protein levels...
Anti-glomerular basement membrane (GBM) nephritis is characterized by circulating anti-GBM antibodies and crescentic glomerulonephritis (GN) with deposition of IgG along the GBM. In a limited number cases, glomerular immune complexes have been identified in nephritis. A 38-year-old female presented azotemia, hematuria, proteinuria without any pulmonary symptoms. renal biopsy showed GN linear GBM mesangial IgA deposition. The patient was diagnosed as concurrent nephropathy. Therapies pulse...
Urine cytology is a noninvasive and inexpensive method; however, it limited in low sensitivity for detecting monitoring urothelial carcinoma (UC). To overcome limitation of cytology, several tests using urine samples have been attempted that immunocytochemical staining an easy to perform ancillary technique. Dual p53 cytokeratin 20 (CK20) assessed liquid-based slides.Liquid-based collected between 2008 2013 matched follow-up biopsy high-grade UC (HGUC) (n = 44) low-grade (LGUC) 14) were...
Lymphangioleiomyomatosis (LAM) is a rare disease usually occurring in young women of child-bearing age. It characterized by distinctive proliferation lymphatic smooth muscle cells, especially the pulmonary parenchyme. The majority primary LAM occurs lung, but there are few reports extrapulmonary cases. We report case 21-yr-old female who first complained low abdominal pain and was referred from local clinic with impression an ovarian cyst. Gynecologic ultrasonography revealed large posterior...
Estrogen receptor (ER) and progesterone (PR) are prognostic markers of breast cancer predictive response to endocrine therapy. To determine rates ER PR expression in invasive carcinoma among Korean women, the Breast Pathology Study Group Society Pathologists collected 1198 specimens from 6 university hospitals. Immunohistochemical analysis was carried out using 1 antibody against 3 antibodies (1D5, 6F11, SP1). Specimens were evaluated semiquantitative Allred score (scores >2 considered...
The aim of this retrospective study was to identify the reliable long term prognostic factors in patients with stage II/III breast cancer who were treated an adjuvant extension neoadjuvant chemotherapy (NC).Women under age 70-years, previously untreated clinical II and III cancer, NC, which comprised three cycles FEC (5-FU, epirubicin, cyclophosphamide every 3 weeks) or MMM (methotrexate, mitoxantrone, mitomycin-C same regimen.Cumulative 10-years disease-free survival (DFS) 87.3% for a good...
Aim: Cluster of differentiation 24 (CD24) is known to be a putative marker stem cell and tumor metastasis. This study aimed verify the clinicopathological value CD24 expression in colorectal adenocarcinoma (CRAC). Materials Methods: A total seven whole-tissue sections malignant polyps including sequence non-neoplastic tissue–adenoma–CRAC, 48 adenomas 161 CRACs arranged as tissue microarray were examined by immunohistochemistry for protein expression. Association with parameters also studied....
Membranous nephropathy (MGN) is the most common cause of nephrotic syndrome in adults. Most cases MGN are primary, but secondary frequently encountered. Determination crucial for initiation appropriate treatment. The diagnostic performance phospholipase A2 receptor (PLA2R) and immunoglobulin G4 (IgG4) detection based on immunohistochemistry were evaluated using biopsy tissues 59 primary 56 discrimination between MGN. PLA2R IgG4 dominantly positive cases. Sensitivity specificity values...
Nephrotic syndrome has been described as one of the clinical forms chronic graft-versus-host disease (cGVHD), but a limited number cases have described. We experienced young female patient with nephrotic developed 22 months after allogeneic hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia. She had well successful management gut-limited cGVHD until she hypoalbuminemia 2.0 g/dL and 24-hr urine protein 6.88 g/dL. On physical examination laboratory findings, there was no...