A5084590075- Renal Transplantation Outcomes and Treatments
- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
- Mechanisms of cancer metastasis
- Blood groups and transfusion
- Cytomegalovirus and herpesvirus research
- Agriculture, Soil, Plant Science
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Immunodeficiency and Autoimmune Disorders
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Erythrocyte Function and Pathophysiology
- Renal Diseases and Glomerulopathies
- Mesenchymal stem cell research
- Prenatal Screening and Diagnostics
- Plant Physiology and Cultivation Studies
- Acute Myeloid Leukemia Research
- Nitrogen and Sulfur Effects on Brassica
- Tuberculosis Research and Epidemiology
- Diabetes and associated disorders
Seoul National University Hospital
2014-2025
Seoul National University
2015-2024
Korea Research Institute of Bioscience and Biotechnology
2003-2023
Weatherford College
2022
Individual Differences
2022
Rural Development Administration
2004-2018
Duke University
2018
Korea International Cooperation Agency
2017
Kyung Hee University
2017
Jones County Junior College
2016
Abstract Background SARS‐CoV‐2 pandemic is currently ongoing, meanwhile vaccinations are rapidly underway in some countries. The quantitative immunoassays detecting antibodies against spike antigen of have been developed based on the findings that they a better correlation with neutralizing antibody. Methods performances Abbott Architect IgG II Quant, DiaSorin LIAISON TrimericS IgG, and Roche Elecsys anti‐SARS‐CoV‐2 S were evaluated 173 sera from 126 patients 151 pre‐pandemic sera. Their...
Using a double-antibody immunoaffinity assay (Luminex) and ELISA technology, we measured concentrations of certain neurotrophins, neuropeptides, cytokines in pooled samples (one to three subjects per sample) eluted from archived neonatal blood children with later-diagnosed autism, Down syndrome, very preterm birth, or term control infants. We also analytes healthy adult controls. Case status for infant was ascertained by retrospective review service agency medical records. observed...
Abstract We searched for potential suppressors of tumor metastasis by identifying the genes that are frequently down-regulated in hepatocellular carcinomas (HCC) while being negatively correlated with clinical parameters relevant to metastasis, and we report here on identification N-myc downstream regulated gene 2 (NDRG2) as a promising candidate. NDRG2 expression was significantly reduced HCC compared nontumor or normal liver tissues [87.5% (35 40) 62% (62 100) at RNA protein levels,...
Wharton’s jelly is not only one of the most promising tissue sources for mesenchymal stem cells (MSCs) but also a source natural growth factors. To prove that we can get both factors and MSCs from jelly, compared cellular characteristics level basic fibroblast factor (bFGF) samples using explant culture method to those derived traditional enzymatic method. The levels bFGF were<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
To define prognostic groups for recurrence-free survival in breast cancer, assess relative effects of factors, and examine the influence treatment variations on patients with similar prognostic-factor profiles.We analyzed 1,055 diagnosed stage I-III cancer between 1990 1996. Variables studied included socioeconomic tumor characteristics, concurrent medical conditions, treatment. The primary end point was (RFS). Multivariable analyses were performed using recursive partitioning Cox...
Abstract Recently, the anti‐tumor activity of N‐myc downstream‐regulated gene 2 (NDRG2) was elucidated, but molecular mechanism how NDRG2 works as a tumor suppressor is not well known. To determine function suppressor, we established stable cell lines expressing protein or its mutant forms, and studied their effects on growth. Interestingly, constitutive expression wild‐type induced growth retardation SW620 colon carcinoma cells. Introduction into cells decrease c‐Jun phosphorylation at...
Although N-myc downstream regulated gene 2 (NDRG2) has been known to be a tumor suppressor gene, the function of this not elucidated. In present study, we investigated expression and NDRG2 in human gastric cancer. Among seven cancer two non-cancer cell lines, only SNU-16 SNU-620, expressed NDRG2, which was detected cytoplasm. Interestingly, highly normal tissues, but patients were divided into NDRG2-positive -negative groups. The survival rate NDRG2-negative lower than that patients. We...
NDRG (N-Myc downstream-regulated gene)-2 is a member of the family. Although it has been suggested that NDRG2 involved in cellular differentiation and tumor suppression, its intracellular signal regulatory mechanism are not well known. Here, we show differential expression human colon carcinoma cell lines tissues by reverse transcription–polymerase chain reaction immunohistochemical analyses with monoclonal antibody against NDRG2. was strongly expressed normal colonic mucosa adenomatous (25...
BACKGROUND: This study was performed to determine the prevalence of antibodies hepatitis B core antigen (anti‐HBc) among Korean blood donors and frequencies virus (HBV) DNA surface (anti‐HBs) in anti‐HBc–positive donors. STUDY DESIGN AND METHODS: A total 12,461 consenting were consecutively enrolled from Red Cross Blood Services April October 2008. All screened for anti‐HBc with an electrochemiluminescence immunoassay. Repeat‐reactive assayed anti‐HBs HBV using a multiplex test (Cobas...
Data on HLA genotype distribution, including DQA1 and DPA1, in the Korean population are limited. We aimed to investigate allele haplotype frequencies of 11 loci 339 subjects using next‐generation sequencing (NGS)‐based typing. A total samples from unrelated healthy were genotyped for HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3, ‐DRB4, ‐DRB5, ‐DQB1, ‐DQA1, ‐DPB1, ‐DPA1 two different NGS‐based typing kits (166 tested NGSgo‐MX11‐3 kit [GenDx, Netherlands] 173 by AllType NGS Loci Amplification [One Lambda,...
Abstract BACKGROUND: Kallikrein‐related peptidase 6 (KLK6) encodes a trypsin‐like serine protease that is up‐regulated in several cancers, although the putative functions of KLK6 cancer have not been elucidated. In current study, overexpression was identified colon cancer, and possibility may be suitable candidate as tumor marker examined. METHODS: Messenger RNA (mRNA) transcript levels protein up‐regulation tissues examined using reverse transcriptase‐polymerase chain reaction,...
Currently, there are two types of interferon-gamma release assays (IGRAs) in use for the detection tuberculosis (TB) infection, QuantiFERON-TB Gold In-Tube test (GFT-GIT) and T-SPOT.TB. Owing to contradictory reports regarding whether results these IGRAs affected by age patient, we aimed determine if tests have age-related differences sensitivity. We retrospectively reviewed medical records diagnosed TB patients who were tested using either QFT-GIT or T-SPOT.TB from February 2008 December...
Combination therapy of intravenous immunoglobulin (IVIG) and rituximab showed a good transplant rate in highly sensitized wait-listed patients for deceased donor kidney transplantation (DDKT), but carried the risk antibody-mediated rejection. The authors investigated impact new combination bortezomib, IVIG, on rate. This study was prospective, open-labeled clinical trial. desensitization regimen consisted 2 doses IVIG (2 g/kg), single dose (375 mg/m2), 4 bortezomib (1.3 mg/m2). analyzed....