A5101798629- Galectins and Cancer Biology
- Macrophage Migration Inhibitory Factor
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- interferon and immune responses
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
- Brain Metastases and Treatment
- Advanced Proteomics Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Nuclear Receptors and Signaling
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
- Pancreatic function and diabetes
National Cancer Center
2016-2025
National Cancer Center
2022
Henan University
2020
Pohang University of Science and Technology
2005
Small interfering RNA (siRNA) holds inherent advantages and great potential for treating refractory diseases. However, lack of suitable siRNA delivery systems that demonstrate excellent circulation stability effective at-site ability is currently impeding therapeutic performance. Here, a polymeric nanomedicine (3I-NM@siRNA) stabilized by triple interactions (electrostatic, hydrogen bond, hydrophobic) constructed. Incorporating extra hydrophobic significantly improves the physiological...
We designed a unique nanocapsule for efficient single CRISPR-Cas9 capsuling, noninvasive brain delivery and tumor cell targeting, demonstrating an effective safe strategy glioblastoma gene therapy. Our nanocapsules can be simply fabricated by encapsulating the Cas9/sgRNA complex within glutathione-sensitive polymer shell incorporating dual-action ligand that facilitates BBB penetration, selective release. evidenced promising tissue targeting led to high PLK1 editing efficiency in (up 38.1%)...
Radiation is a core part of therapy for malignant glioma and often provided following debulking surgery. However, resistance to radiation occurs in most patients, the underlying molecular mechanisms radio-resistance are not fully understood. Here, we demonstrated that microRNA 21 (miR-21), well-known onco-microRNA glioma, one major players radio-resistance. Radio-resistance different cell lines measured by cytotoxic survival assay was closely associated with miR-21 expression level. Blocking...
Abstract The interplay between glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) promotes progression of multiforme (GBM). However, the detailed molecular mechanisms underlying relationship these two cell types remain unclear. Here, we demonstrate that ARS2 (arsenite-resistance protein 2), a zinc finger is essential for early mammalian development, plays critical roles in GSC maintenance M2-like TAM polarization. directly activates its novel transcriptional target MGLL ,...
Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM), but inevitably induces poorly understood global changes in GBM and its microenvironment (TME) that promote radio-resistance recurrence. Through a cell surface marker screen, we identified CD142 (tissue factor or F3) is robustly induced the senescence-associated β-galactosidase (SA-βGal)-positive cells after irradiation. F3 promotes clonal expansion of irradiated SA-βGal+ orchestrates oncogenic TME...
Abstract Diffuse infiltration is the main reason for therapeutic resistance and recurrence in glioblastoma (GBM). However, potential targeted therapies GBM stem-like cell (GSC) which responsible invasion are limited. Herein, we report Insulin-like Growth Factor-Binding Protein 5 (IGFBP5) a ligand Receptor tyrosine kinase like Orphan 1 (ROR1), as promising target GSC invasion. Using GSC-derived brain tumor model, GSCs were characterized into invasive or non-invasive subtypes, RNA sequencing...
Abstract Glioma-initiating cells (GIC), which reside within the perivascular microenvironment to maintain self-renewal capacity, are responsible for glioblastoma initiation, progression, and recurrence. However, molecular mechanisms controlling crosstalk between GICs endothelial poorly understood. Here, we report that, in both cells, platelet-derived growth factor (PDGF)–driven activation of nitric oxide (NO) synthase increases NO-dependent inhibitor differentiation 4 (ID4) expression, turn...
Necrosis is a hallmark of glioblastoma (GBM) and responsible for poor prognosis resistance to conventional therapies. However, the molecular mechanisms underlying necrotic microenvironment-induced malignancy GBM have not been elucidated. Here, we report that transglutaminase 2 (TGM2) upregulated in perinecrotic region triggered mesenchymal (MES) transdifferentiation glioma stem cells (GSC) by regulating master transcription factors (TF), such as C/EBPβ, TAZ, STAT3. TGM2 expression was...
Upregulation of microRNA-21 (miR-21) is known to be strongly associated with the proliferation, invasion, and radio-resistance glioma cells. However, regulatory mechanism that governs biogenesis miR-21 in still unclear. Here, we demonstrate DEAD-box RNA helicase, DDX23, promotes at post-transcriptional level. The expression DDX23 was enhanced tissues compared normal brain, level highly poor survival patients. Specific knockdown suppressed cell proliferation invasion vitro vivo, which similar...
Epidermal growth factor receptor variant III (EGFRvIII) has been associated with glioma stemness, but the direct molecular mechanism linking two is largely unknown. Here, we show that EGFRvIII induces expression and secretion of pigment epithelium-derived (PEDF) via activation signal transducer activator transcription 3 (STAT3), thereby promoting self-renewal tumor progression stem cells (GSCs). Mechanistically, PEDF sustained GSC by Notch1 cleavage, generated intracellular domain (NICD)...
Radiation-induced autophagy has been shown to play two different roles, in malignant glioma (MG) cells, cytocidal or cytoprotective. However, neither the role of radiation-induced for cell death nor existence autophagy-induced apoptosis, a well-known cell-death pathway after irradiation, verified yet.We observed both temporal and dose-dependent response patterns apoptosis radiation MG lines. Additionally, we investigated through knockdown autophagy-related proteins.Autophagic activity...
Abstract Nanoformulations show great potential for delivering drugs to treat brain tumors. However, how the mechanical properties of nanoformulations affect their ultimate destination is still unknown. Here, a library membrane‐crosslinked polymersomes with different elasticity are synthesized investigate ability effectively target Crosslinked identical particle size, zeta and shape assessed, but varied depending on rigidity incorporated crosslinkers. Benzyl oxyethylene containing...
The greatest challenge in cancer therapy is posed by drug-resistant recurrence following treatment. Anticancer chemotherapy largely focused on targeting the rapid proliferation and biosynthesis of cells. This strategy has potential to trigger autophagy, enabling cell survival through recycling molecules energy essential for biosynthesis, leading drug resistance. Autophagy contributes amino acids ATP restore mTOR complex 1 (mTORC1) activity, which leads survival. However, autophagy with...
Abstract Glioblastoma is the most common type of malignant primary brain tumor and displays highly aggressive heterogeneous phenotypes. The transcription factor STAT3 has been reported to play a key role in glioblastoma malignancy. Thus, discovering targets functional downstream networks regulated by that govern pathogenesis may lead improved treatment strategies. In this study, we identified poly(A)-specific ribonuclease (PARN), modulator RNA metabolism, activates EGFR–STAT3 signaling...
<title>Abstract</title> Current treatment strategies for medulloblastoma remain ineffective due to extensive tumor heterogeneity. In this study, we performed integrated multi-omic characterization improve the conventional molecular classification of medulloblastoma, leading identification seven refined distinct subtypes. The SHH group was reclassified into two subgroups, SHHα and SHHβ, while 4 divided three G4α, G4β, G4γ. Group subtypes exhibit neuronal differentiation trajectories: granular...
Constitutively activated STAT3 plays an essential role in the initiation, progression, maintenance, malignancy, and drug resistance of cancer, including glioblastoma, suggesting that is a potential therapeutic target for cancer therapy. We recently identified ODZ10117 as small molecule inhibitor suggested it may have effective utility STAT3-targeted Here, we demonstrated efficacy glioblastoma by targeting STAT3. inhibited migration invasion induced apoptotic cell death cells patient-derived...
The liver-specific microRNA, miR-122, plays an essential role in the propagation of hepatitis C virus (HCV) by binding directly to 5′-end its genomic RNA. Despite significance for HCV proliferation, host factors responsible regulating miR-122 remain largely unknown. In this study, we identified cellular RNA-binding protein, ELAVL1/HuR (embryonic lethal-abnormal vision-like 1/human antigen R), as critically contributing biogenesis strong 3′-end miR-122. availability was highly correlated with...
// Jinlong Yin 1, 3 , Tae-Hoon Kim Nayun Park 2 Daye Shin Hae In Choi Sungchan Cho 4 Jong Bae Heon 1 Department of System Cancer Science, Graduate School Science and Policy, National Center, Goyang, Gyeonggi, Korea Cell Molecular Biology Branch, Research Institute, Specific Organs Anticancer Agent Institute Bioscience & Biotechnology, Ochang, Correspondence to: Kim, email: jhkim@ncc.re.kr Park, jbp@ncc.re.kr Keywords: TRIM71, Lin28B, let-7, HMGA2, tumorigenesis Received: September 16, 2016...
Leptomeningeal metastasis (LM) is a common and fatal complication of advanced non-small cell lung cancer (NSCLC) caused by the spread malignant cells to leptomeninges cerebrospinal fluid (CSF). While intra-CSF methotrexate (MTX) chemotherapy can improve prognosis, eventual MTX resistance deters continued chemotherapy. Recent studies have shown that increased miRNA-21 (miR-21) expression in CSF patients with LM after intraventricular MTX-chemotherapy associated poor overall survival; however,...