A5005999525- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- Neurogenesis and neuroplasticity mechanisms
- TGF-β signaling in diseases
- Cancer Research and Treatments
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Animal Genetics and Reproduction
- Telomeres, Telomerase, and Senescence
- Mesenchymal stem cell research
- Influenza Virus Research Studies
- FOXO transcription factor regulation
- Retinoids in leukemia and cellular processes
- RNA Research and Splicing
Korea University
2016-2025
Bipar
2013
Samsung Medical Center
2011-2012
National University College
2012
Sungkyunkwan University
2011-2012
Biomedical Research Institute
2012
New Generation University College
2012
Seoul National University
1996-2012
Cleveland Clinic Lerner College of Medicine
2012
Konkuk University
2011
A number of recent reports have demonstrated that only CD133-positive cancer cells glioblastoma multiforme (GBM) tumor-initiating potential. These findings raise an attractive hypothesis GBMs can be cured by eradicating stem (CSCs), which are a small portion GBM cells. However, as known to possess various genetic alterations, might harbor heterogeneous CSCs with different alterations. Here, we compared the clinical characteristics two patient groups divided according cell ratios. The...
Glioma stem cells (GSC) possess tumor-initiating potential and are relatively resistant to conventional chemotherapy irradiation. Thus, they considered be major drivers for glioma initiation, progression, recurrence. However, the precise mechanism governing acquisition of their drug resistance remains elucidated. Our previous study has shown that inhibitor differentiation 4 (ID4) dedifferentiates Ink4a/Arf(-/-) mouse astrocytes human stem-like (induced GSCs or iGSCs). In this article, we...
ABSTRACT Adaptation of influenza A viruses to a new host species usually involves the mutation one or more eight viral gene segments, and molecular basis for range restriction is still poorly understood. To investigate changes that occur during adaptation low-pathogenic avian virus subtype commonly isolated from migratory birds mammalian host, we serially passaged avirulent wild-bird H5N2 strain A/Aquatic bird/Korea/W81/05 (W81) in lungs mice. The resulting mouse-adapted (ma81) was highly...
Glioblastoma (GBM) is an astrocytic brain tumor characterized by aggressive clinical course and intense resistance to all therapeutic modalities. Here, we report the identification functional characterization of Bcl2L12 (Bcl2-like-12) that robustly expressed in nearly human primary GBMs examined. Enforced expression confers marked apoptosis cortical astrocytes, and, conversely, its RNA interference (RNAi)-mediated knockdown sensitizes glioma cell lines toward vitro impairs growth with...
Abstract Glioblastomas multiforme (GBM) contain highly tumorigenic, self-renewing populations of stem/initiating cells [glioblastoma stem (GSC)] that contribute to tumor propagation and treatment resistance. However, our knowledge the specific signaling pathways regulate GSCs is limited. The MET tyrosine kinase known stimulate survival, proliferation, invasion various cancers including GBM. Here, we identified a distinct fraction expressing high level in human primary GBM specimens were...
One of the most detrimental hallmarks glioblastoma multiforme (GBM) is cellular invasiveness, which considered a potential cause tumor recurrence. Infiltrated GBM cells are difficult to completely eradicate surgically and with local therapeutic modalities. Although much effort has focused on understanding various mechanisms controlling its nature remains poorly understood. In this study, we established highly serial intracranial transplantation. U87R4 were invasive displayed stem cell-like...
Abstract Aberrant activation of receptor tyrosine kinases (RTK) is causally linked to the pathobiological traits glioblastoma and genesis glioma stem-like cells (GSC), but underlying mechanism still unknown. Here, we show that epidermal growth factor (EGFR) signaling regulates proliferation, angiogenesis, acquisition GSC characteristics by inducing inhibitor differentiation 3 (ID3) ID3-regulated cytokines [GRO1 interleukins (IL)-6 8] induction. We found EGFR-mediated ID3 expression was...
Abstract The interplay between glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) promotes progression of multiforme (GBM). However, the detailed molecular mechanisms underlying relationship these two cell types remain unclear. Here, we demonstrate that ARS2 (arsenite-resistance protein 2), a zinc finger is essential for early mammalian development, plays critical roles in GSC maintenance M2-like TAM polarization. directly activates its novel transcriptional target MGLL ,...
With the emergence of multiple predominant SARS-CoV-2 variants, it becomes important to have a comprehensive assessment their viral fitness and transmissibility. Here, we demonstrate that natural temperature differences between upper (33°C) lower (37°C) respiratory tract profound effects on replication Specifically, variants containing NSP12 mutations P323L or P323L/G671S exhibit enhanced RNA-dependent RNA polymerase (RdRp) activity at 33°C compared with 37°C high Molecular dynamics...
Abstract Background Glioblastoma (GBM) is more difficult to treat than other intractable adult tumors. The main reason that GBM so it highly infiltrative. Migrasomes are newly discovered membrane structures observed in migrating cells. Thus, they can be generated from cells have the ability migrate along brain parenchyma. However, function of migrasomes has not yet been elucidated Results Here, we describe composition and with cell migration. Proteomic analysis revealed LC3B-positive...
Cellular origins and genetic factors governing the genesis maintenance of glioblastomas (GBM) are not well understood. Here, we report a pathogenetic role developmental regulator Id4 (inhibitor differentiation 4) in GBM. In primary murine Ink4a/Arf −/− astrocytes, human glioma cells, provide evidence that enforced can drive malignant transformation by stimulating increased cyclin E to produce hyperproliferative profile Jagged1 expression with Notch1 activation astrocytes into neural...
Abstract Glioma-initiating cells (GIC), which reside within the perivascular microenvironment to maintain self-renewal capacity, are responsible for glioblastoma initiation, progression, and recurrence. However, molecular mechanisms controlling crosstalk between GICs endothelial poorly understood. Here, we report that, in both cells, platelet-derived growth factor (PDGF)–driven activation of nitric oxide (NO) synthase increases NO-dependent inhibitor differentiation 4 (ID4) expression, turn...
Upregulation of microRNA-21 (miR-21) is known to be strongly associated with the proliferation, invasion, and radio-resistance glioma cells. However, regulatory mechanism that governs biogenesis miR-21 in still unclear. Here, we demonstrate DEAD-box RNA helicase, DDX23, promotes at post-transcriptional level. The expression DDX23 was enhanced tissues compared normal brain, level highly poor survival patients. Specific knockdown suppressed cell proliferation invasion vitro vivo, which similar...
Epidermal growth factor receptor variant III (EGFRvIII) has been associated with glioma stemness, but the direct molecular mechanism linking two is largely unknown. Here, we show that EGFRvIII induces expression and secretion of pigment epithelium-derived (PEDF) via activation signal transducer activator transcription 3 (STAT3), thereby promoting self-renewal tumor progression stem cells (GSCs). Mechanistically, PEDF sustained GSC by Notch1 cleavage, generated intracellular domain (NICD)...
Abstract Purpose: The potential of metastasis can be predicted from clinical features like tumor size, histologic grade, and gene expression patterns. We examined the whole-genome transcriptomic profile a xenograft model breast cancer to understand characteristics brain metastasis. Experimental Design: Variants MDA-MB-435 cell were established experimental metastases. LvBr2 variant was isolated lesions in mouse injected left ventricle heart, these cells used for two cycles injection into...
Tumor metastasis involves circulating and tumor‐initiating capacities of metastatic cancer cells. Epithelial‐mesenchymal transition (EMT) is related to self‐renewal capacity tumor cell (CTC) characteristics for metastasis. Although a life‐threatening, complicated process that occurs through circulation cells, mechanistic aspects have been largely unknown. Hepatic transmembrane 4 L six family member 5 (TM4SF5) promotes EMT malignant growth migration, so it was rationalized TM4SF5, as...
Glioblastoma multiforme (GBM) is one of the most aggressive and fatal primary brain tumors in humans. The standard therapy for treatment GBM surgical resection, followed by radiotherapy and/or chemotherapy. However, frequency tumor recurrence patients very high, survival rate remains poor. Delineating mechanisms essential therapeutic advances. Here, we demonstrate that irradiation rendered 17–20 % cells dead, but resulted 60–80 growth-arrested with increases senescence markers, such as...