A5015284985- Platelet Disorders and Treatments
- Prostate Cancer Treatment and Research
- Blood properties and coagulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood disorders and treatments
- Blood groups and transfusion
- Cell Adhesion Molecules Research
- Prostate Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Immune Cell Function and Interaction
- Urinary Bladder and Prostate Research
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Antiplatelet Therapy and Cardiovascular Diseases
- Proteoglycans and glycosaminoglycans research
- Immunotherapy and Immune Responses
- Heparin-Induced Thrombocytopenia and Thrombosis
- Renal Diseases and Glomerulopathies
- Sperm and Testicular Function
- Carcinogens and Genotoxicity Assessment
- Testicular diseases and treatments
- Multiple Myeloma Research and Treatments
- Genomics and Rare Diseases
- Glycosylation and Glycoproteins Research
Universitätsklinikum Würzburg
2016-2025
University of Würzburg
2014-2023
IPB University
2022-2023
Deutsche Bahn (Germany)
2022
Institute for Biomedicine
2020-2021
Charité - Universitätsmedizin Berlin
2007-2017
MSB Medical School Berlin
2012-2013
Agaplesion Markus Hospital
2011
University of Bonn
2011
Klinik und Poliklinik für Kinder- und Jugendmedizin
2010
Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood. Here we describe the use of multiphoton intravital microscopy intact BM to visualize platelet generation mice. MKs were observed as sessile cells extended dynamic proplatelet-like protrusions into microvessels. These intravascular extensions appeared be sheared their transendothelial stems flowing blood, resulting appearance proplatelets peripheral blood. In vitro,...
Purpose: To prospectively assess potential risk factors for relapse in clinical stage I nonseminomatous germ cell tumors of the testis (CS NSGCT). Patients and Methods: From September 1996 to May 2002, 200 patients with CS NSGCT were assigned retroperitoneal lymph node dissection (RPLND), factor assessment was performed within a multicenter protocol. One hundred sixty-five had an adequate minimum follow-up 12 months (mean, 34.5 months) or pathologic II. Results: Pathologic II disease found...
Inhaltsverzeichnis Kapitel 1: Methodik 1275 Hintergrund 1276 2: Klinische Diagnostik 1278 Klassifikation Krankengeschichte 1279 Diagnosestellung 1281 Endoskopische 1283 Differenzialdiagnostische Abgrenzung zum Morbus Crohn Bestimmung der Krankheitsaktivität Ultraschall 1284 Kolonstenose bei Colitis ulcerosa Pädiatrie 3: Histopathologische 1285 Entzündungsdiagnostik Intraepitheliale Neoplasien (IEN) 1286 4: Akuter Schub 1287 Proktitis Linksseitenkolitis 1288 Ausgedehnter Befall 1289 Schwere...
Changes in cytoplasmic Ca2+ levels regulate a variety of fundamental cellular functions virtually all cells. In nonexcitable cells, major pathway entry involves receptor-mediated depletion intracellular stores followed by the activation store-operated calcium channels plasma membrane. We have established mouse line expressing an activating EF hand motif mutant stromal interaction molecule 1 (Stim1), ER receptor recently identified as sensor responsible for release–activated (CRAC) T whose...
Glioblastoma (GBM) is an astrocytic brain tumor characterized by aggressive clinical course and intense resistance to all therapeutic modalities. Here, we report the identification functional characterization of Bcl2L12 (Bcl2-like-12) that robustly expressed in nearly human primary GBMs examined. Enforced expression confers marked apoptosis cortical astrocytes, and, conversely, its RNA interference (RNAi)-mediated knockdown sensitizes glioma cell lines toward vitro impairs growth with...
Abstract In mammals, megakaryocytes (MKs) in the bone marrow (BM) produce blood platelets, required for hemostasis and thrombosis. MKs originate from hematopoietic stem cells are thought to migrate an endosteal niche towards vascular sinusoids during their maturation. Through imaging of intact BM, here we show that can be found within entire without a bias bone-distant regions. By combining vivo two-photon microscopy situ light-sheet fluorescence with computational simulations, reveal...
Abstract Mg 2+ plays a vital role in platelet function, but despite implications for life-threatening conditions such as stroke or myocardial infarction, the mechanisms controlling [Mg ] i megakaryocytes (MKs) and platelets are largely unknown. Transient receptor potential melastatin-like 7 channel (TRPM7) is ubiquitous, constitutively active cation with cytosolic α-kinase domain that critical embryonic development cell survival. Here we report impaired function of TRPM7 MKs causes...
Abstract The structure of the human caput epididymidis was examined by gross morphological and light electron microscopic techniques. There were at least seven types tubules, each characterized a different epithelium. These tubules connected with one another eight junctions to form network. Most composed efferent ducts. Within these, five ciliated epithelium, found in regions; four between ducts epididymal tubule observed. left testis, initially as parallel straight containing both...
Very little is known about the basal cells in epididymal epithelium. Their function unclear, although they are present all mammalian epididymides studied. The corpus from five patients undergoing castration because of prostatic carcinoma were fixed and processed for electron microscopy. Basal characterized by a slightly heterochromatic nucleus with prominent nucleolus, pale round mitochondria, dispersed endoplasmic reticulum, sparse Golgi apparatus; often rich lipofuscin inclusions, possibly...
It has been established in laboratory mammals that sperm motility and fertilizing capacity develop during epididymal transit, but maturation along the human epididymis is less well characterized. Spermatozoa were prepared from 5 regions of 8 epididymides prostatic carcinoma patients undergoing castration spermatocoeles located adjacent to head testes patients. Sperm movement was characterized by computer-aided analysis (CASA), percentage estimated conventional methods. The efferent ducts...
The detection of antibodies against the human leukocyte antigen (HLA) complex has become indispensable in every clinical practice. development solid-phase assays like Luminex allows standardized measurement anti-HLA (HLAab) with high sensitivity, albeit relevance for some settings remains a matter debate. In this review we aim to describe principle Luminex-based antibody detection, including two modifications that allow identifying solely complement-activating antibodies. We then three...