A5044500238- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Chemokine receptors and signaling
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Sphingolipid Metabolism and Signaling
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Platelet Disorders and Treatments
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Psoriasis: Treatment and Pathogenesis
- Influenza Virus Research Studies
- Long-Term Effects of COVID-19
- Gut microbiota and health
- Eosinophilic Esophagitis
- NF-κB Signaling Pathways
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Advanced Biosensing Techniques and Applications
Novartis (Switzerland)
2013-2025
Novartis Institutes for BioMedical Research
2009-2023
University Hospital of Lausanne
2020
University of Lausanne
2020
Novartis (Netherlands)
2020
Harvard University
2006-2008
University Hospital of Zurich
1999-2008
Novartis (Austria)
2008
Brigham and Women's Hospital
2007
Barcelona Biomedical Research Park
2007
Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic (DC) GALT induce T cell-independent expression of IgA and gut-homing receptors on cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote secretion. However, RA potently synergized with interleukin-6 (IL-6) or IL-5 to Consequently, mice deficient the precursor vitamin lacked...
Platelets are generated from megakaryocytes (MKs) in mammalian bone marrow (BM) by mechanisms that remain poorly understood. Here we describe the use of multiphoton intravital microscopy intact BM to visualize platelet generation mice. MKs were observed as sessile cells extended dynamic proplatelet-like protrusions into microvessels. These intravascular extensions appeared be sheared their transendothelial stems flowing blood, resulting appearance proplatelets peripheral blood. In vitro,...
When SUCNR1/GPR91-expressing macrophages are activated by inflammatory signals, they change their metabolism and accumulate succinate. In this study, we show that during activation, release succinate into the extracellular milieu. They simultaneously up-regulate GPR91, which functions as an autocrine paracrine sensor for to enhance IL-1β production. GPR91-deficient mice lack metabolic reduced macrophage activation production of antigen-induced arthritis. Succinate is abundant in synovial...
Highlights•The microbiota contributes to helminth-induced modulation of allergic asthma•Cecal microbial communities are altered in helminth-infected mice•Helminth infection increases microbial-derived short chain fatty acids•GPR41 mediates Treg cell suppressor functionSummaryIntestinal helminths potent regulators their host's immune system and can ameliorate inflammatory diseases such as asthma. In the present study we have assessed whether this anti-inflammatory activity was purely...
Immune mechanisms are known to control the pathogenesis of atherosclerosis. However, exact role DCs, which essential for priming immune responses, remains elusive. We have shown here that DC-derived chemokine CCL17 is present in advanced human and mouse atherosclerosis CCL17+ DCs accumulate atherosclerotic lesions. In atherosclerosis-prone mice, Ccl17 deficiency entailed a reduction atherosclerosis, was dependent on Tregs. Expression by limited expansion Tregs restricting their maintenance...
Abstract Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute syndrome coronavirus 2 (SARS-CoV-2), which has grown to worldwide pandemic with substantial mortality. Immune mediated damage been proposed as pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles post mortem ( n = 34 tissues from 16 patients) normal lung 9 6 patients). Two distinct...
<h3>Objective</h3> Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated cytokine network, but novel therapeutic principles are urgently needed. Here we identify the interleukin (IL)-33 and its receptor ST2 as key negative regulators of wound healing permeability in colon mice. <h3>Design</h3> Expression IL-33 was determined by qRT-PCR, ELISA, immunohistochemistry western-blot analysis. Wild-type <i>St2</i><sup>−/−</sup> mice were used experiments two experimental...
Abstract Persistence is a hallmark of infection by viruses such as HIV, hepatitis B virus, C virus and LCMV. In the case LCMV, persistence may often be associated with exhaustion CD8 + T cells. We demonstrate here that persistent antigen suppressed IL‐7Rα expression this correlated cell reduced anti‐apoptotic molecule leukemia/lymphoma 2 (Bcl‐2). contrast, exposure to short‐lived only temporarily expression, failed induce exhaustion, primed Persistent also on cells previously stable...
The liver is known to be a classical immunoprivileged site with relatively high resistance against immune responses. Here we demonstrate that highly activated liver-specific effector CD8+ T cells alone were not sufficient trigger destruction of the in mice. Only additional innate signals orchestrated by TLR3 provoked damage. While activation did directly alter cell function, it induced IFN-α and TNF-α release. These cytokines generated expression chemokine CXCL9 liver, thereby enhancing...
Millions of platelets are produced each hour by bone marrow (BM) megakaryocytes (MKs). MKs extend transendothelial proplatelet (PP) extensions into BM sinusoids and shed new the blood. The mechanisms that control platelet generation remain incompletely understood. Using conditional mutants intravital multiphoton microscopy, we show here lipid mediator sphingosine 1-phosphate (S1P) serves as a critical directional cue guiding elongation megakaryocytic PP from interstitium triggering...