A5070607785- Virus-based gene therapy research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Rabies epidemiology and control
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Leptospirosis research and findings
- Quantum Chromodynamics and Particle Interactions
- Viral Infections and Vectors
- High-Energy Particle Collisions Research
- Vector-borne infectious diseases
- Veterinary Oncology Research
- Nuclear physics research studies
- Research on Leishmaniasis Studies
- Parvovirus B19 Infection Studies
- Microbial infections and disease research
- Particle physics theoretical and experimental studies
- Human-Animal Interaction Studies
- HIV Research and Treatment
- Clostridium difficile and Clostridium perfringens research
- Bartonella species infections research
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Pelvic and Acetabular Injuries
Ludwig-Maximilians-Universität München
2016-2025
LMU Klinikum
2017-2024
Bayer (Germany)
2020
IDEXX Laboratories (Germany)
2020
Freie Universität Berlin
2019
Universität Ulm
1991-2014
University of Bern
2012
University of Fribourg
2011
Ruhr University Bochum
1990-2006
University of Münster
1991
A new anterior intrapelvic approach for the surgical management of displaced acetabular fractures involving predominantly column and quadrilateral plate is described. In order to establish five ‘windows’ instrumentation, extraperitoneal space entered along lateral border rectus abdominis muscle. This so-called ‘Pararectus’ approach. The feasibility safe dissection optimal instrumentation pelvis was assessed in cadavers (ten hemipelves) before implementation a series 20 patients with mean age...
This study investigated the impact of comorbidity in 555 patients with chronic lymphocytic leukemia enrolled two trials German Chronic Lymphocytic Leukemia Study Group on first-line treatment fludarabine plus cyclophosphamide, fludarabine, or chlorambucil. Patients more comorbidities and less than differed overall survival (71.7 versus 90.2 months; P<0.001) progression-free (21.0 31.5 P<0.01). After adjustment for other prognostic factors treatment, maintained its independent value a...
Re-vaccinations against canine distemper virus (CDV) are commonly performed in 3-year intervals. The study's aims were to determine anti-CDV antibodies healthy adult dogs within 28 days of vaccination CDV, and evaluate factors associated with the presence pre-vaccination antibody response vaccination. Ninety-seven dogs, not vaccinated 1 year before enrollment, a modified live CDV vaccine. A measurement was (day 0), on day 7, after by neutralization. defined as ≥4-fold titer increase 28....
Objectives Feline infectious peritonitis (FIP), a common disease in cats caused by feline coronavirus (FCoV), is usually fatal once clinical signs appear. Successful treatment of FIP with oral GS-441524 for 84 days was demonstrated recently this research group. The aim study to evaluate the long-term outcome these cats. Methods A total 18 successfully treated were followed up 1 year after initiation (9 months completion antiviral treatment). Follow-up examinations performed at 12-week...
Abstract The structure of the human caput epididymidis was examined by gross morphological and light electron microscopic techniques. There were at least seven types tubules, each characterized a different epithelium. These tubules connected with one another eight junctions to form network. Most composed efferent ducts. Within these, five ciliated epithelium, found in regions; four between ducts epididymal tubule observed. left testis, initially as parallel straight containing both...
Feline infectious peritonitis (FIP) caused by feline coronavirus (FCoV) is a common dis-ease in cats, fatal if untreated, and no effective treatment currently legally available. The aim of this study was to evaluate efficacy toxicity the multi-component drug Xraphconn® vitro as oral cats with spontaneous FIP examining survival rate, development clinical laboratory parameters, viral loads, anti-FCoV antibodies, adverse effects. Mass spectrometry nuclear magnetic resonance identified GS-441524...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people globally since its first detection in late 2019. Besides humans, cats and, to some extent, dogs were shown be susceptible SARS-CoV-2, highlighting the need for surveillance a One Health context. Seven veterinary clinics from regions with high incidences disease (COVID-19) recruited during early pandemic (March July 2020) screening patients. A total 2257 oropharyngeal and nasal swab specimen 877 260...
In the past, feline infectious peritonitis (FIP) caused by coronavirus (FCoV) was considered fatal. Today, highly efficient drugs, such as GS-441524, can lead to complete remission. The currently recommended treatment duration in veterinary literature is 84 days. This prospective randomized controlled study aimed evaluate whether a shorter of 42 days with oral GS-441524 obtained from licensed pharmacy equally effective compared 84-day regimen. Forty cats FIP effusion were prospectively...
Objectives Clinical manifestation of infection with Leptospira species in cats is rare. Nevertheless, can develop specific antibodies against the spirochetes after infection. In Canada, Taiwan and USA it was recently demonstrated that naturally infected also shed DNA from pathogenic their urine, but zoonotic potential still unclear. The objective this study to demonstrate if outdoor Germany urine. As a second aim, antibody prevalence determined. Methods Two hundred fifteen were prospectively...
As previously demonstrated by our research group, the oral multicomponent drug Xraphconn® containing GS-441524 was effective at curing otherwise fatal feline infectious peritonitis (FIP) in 18 coronavirus (FCoV)-infected cats. The aims of current study were to investigate, using samples from same animals as previous study, (1) effect treatment on fecal viral RNA shedding; (2) presence spike gene mutations different body compartments these cats; and (3) shedding, mutations, anti-FCoV antibody...
Hemoplasma species (spp.) commonly cause infections in cats worldwide. However, data on risk factors for are limited. The aim of this study was to determine the prevalence hemoplasma spp. Southern Germany and assess associated with infection. DNA extracted from blood samples 479 presented different veterinary hospitals various reasons. feline hemoplasmas amplified by use a previously reported PCR assay. Direct sequencing used confirm all purified amplicons compared sequences GenBank. Results...
Feline coronavirus (FCoV) infection is ubiquitous in multi-cat households. Responsible for the continuous presence are cats that chronically shedding a high load of FCoV. The aim study was to determine possible correlation between FCoV antibody titer and frequency fecal from catteries.Four samples each 82 originating 19 German catteries were examined viral loads by quantitative reverse transcriptase polymerase chain reaction (RT-qPCR). Additionally, titers determined an immunofluorescence...
The aim of this prospective study was to determine prevalence and potential risk factors feline coronavirus (FCoV) shedding. Four consecutive fecal samples 179 cats from 37 German breeding catteries were analyzed for FCoV ribonucleic acid (RNA) by real-time reverse transcriptase polymerase chain reaction (RT-qPCR). Prevalence shedding calculated using different numbers per cat (1-4) sampling intervals (5-28 days). Information on obtained a questionnaire. Risk factor analysis performed...
Prevalence of progressive feline leukaemia virus (FeLV) infection is known to still be high in cats Europe, especially Southern but the prevalence other outcomes FeLV has not been determined most countries. The present study aimed investigate progressive, regressive, abortive, and focal four European countries, two with a (Italy, Portugal) low expected (Germany, France). Blood samples 934 (Italy: 269; Portugal: 240; France: 107; Germany: 318) were evaluated for p27 antigen, as well...
In Thailand, leptospirosis is considered an emerging disease in humans and animals. Many species can shed pathogenic Leptospira, including domestic cats (felis catus), which might be able to pose a risk humans. There are no studies on Leptospira infections but other countries, it was demonstrated that with high prevalences. The aims of this study were evaluate whether outdoor Thailand their urine, determine antibody prevalence factors associated infection. Two hundred sixty prospectively...
According to prior studies, between 25.0% and 92.8% of adult cats have antibodies against feline panleukopenia virus (FPV) thus are likely protected FPV infection. It is, however, unknown how healthy with different antibody titres react vaccination in the field. Therefore, aim study was measure within a period 28 days after evaluate factors that associated lack adequate response vaccination.
Positive canine parvovirus (CPV) faecal test results have been reported in dogs after modified live virus (MLV) vaccination. Thus, the aim was to investigate feline panleucopenia (FPV) shedding recently vaccinated, adult, clinically healthy cats and assess related factors. Forty were vaccinated with an FPV MLV vaccine. Faeces of tested for presence DNA on days 7, 14, 21 28 by quantitative real-time PCR; DNA-positive samples subjected partial VP2 gene sequencing. Virus isolation performed...
Vaccination is the most important preventive measure for protection against infectious diseases in humans and companion animals. Nevertheless, scepticism about safety importance of vaccines increasing human veterinary medicine. Although owner attitudes towards vaccination have been investigated cats, there are no similar studies dogs. The goals this study were therefore to investigate status dogs Germany, determine compliance with identify factors that play a role owners' decisions their...
(1) Background: This study aimed to determine the risk factors for outbreaks of feline panleukopenia in shelters. (2) Methods: Four shelters (A−D) with 150 cats were included. Fecal samples analyzed by parvovirus real-time polymerase chain reaction (qPCR), including culture and sequencing qPCR-positive samples. Information on cats, husbandry, hygiene, infection management was evaluated shedding logistic regression. (3) Results: Feline occurred 28.0% (42/150) (0 shelter D). Shedding found...
(1) Background: This study aimed to detect feline coronavirus (FCoV) and characterize spike (S) gene mutation profiles in cats suffering from diseases other than infectious peritonitis (FIP) using commercial real-time reverse transcription polymerase chain reaction (RT-qPCR) reevaluating results by sequencing. (2) Methods: In 87 which FIP was excluded histopathology immunohistochemistry, FCoV 7b S RT-qPCR performed prospectively on incisional biopsies fine-needle aspirates of different...