A5005176683- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Insect and Pesticide Research
- Insect and Arachnid Ecology and Behavior
- COVID-19 Clinical Research Studies
- Plant and animal studies
- Bee Products Chemical Analysis
- SARS-CoV-2 detection and testing
- Essential Oils and Antimicrobial Activity
- Viral Infections and Outbreaks Research
- Respiratory viral infections research
- Mosquito-borne diseases and control
- Aquaculture disease management and microbiota
- Influenza Virus Research Studies
- RNA and protein synthesis mechanisms
- Parvovirus B19 Infection Studies
- Antimicrobial Peptides and Activities
- Viral Infectious Diseases and Gene Expression in Insects
- Antibiotic Resistance in Bacteria
- Herpesvirus Infections and Treatments
- Cellular transport and secretion
- Neurobiology and Insect Physiology Research
- HIV Research and Treatment
Sichuan Agricultural University
2015-2025
Environment and Plant Protection Research Institute
2017-2025
Chinese Academy of Tropical Agricultural Sciences
2017-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Science and Technology Department of Sichuan Province
2025
Dalian Institute of Chemical Physics
2023
Chinese Academy of Sciences
2023
Utrecht University
2019-2022
Chengdu Academy of Agriculture and Forestry Sciences
2022
Southern Medical University
2018-2021
A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused the pandemic of COVID-19. The origin SARS-CoV-2 was associated with zoonotic infections.
Animals like mink, cats and dogs are susceptible to SARS-CoV-2 infection. In the Netherlands, 69 out of 127 mink farms were infected with between April November 2020 all on culled after infection prevent further spread virus. On some farms, (feral) present. This study provides insight into prevalence SARS-CoV-2-positive in 10 their possible role transmission Throat rectal swabs 101 (12 domestic 89 feral cats) 13 tested for using PCR. Serological assays performed serum samples from 62 adult...
The current global pandemic of COVID-19 is caused by a novel coronavirus SARS-CoV-2. SARS-CoV-2 spike protein receptor-binding domain (RBD) the critical determinant viral tropism and infectivity. To investigate whether naturally occurring mutations in RBD have altered receptor binding affinity infectivity, firstly we analyzed silico dynamics between mutated RBDs human ACE2 receptor. Among 1609 genomes strains isolated during early transmission phase, 32 non-synonymous mutants were identified...
Since the emergence of coronavirus disease (COVID-19) in late 2019, domestic cats have been demonstrated to be susceptible severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) under natural and experimental conditions. As pet often live very close contact with their owners, it is essential investigate SARS-CoV-2 infections a One-Health context. This study reports first infection cat COVID-19-affected household Switzerland. The (Cat 1) signs an upper tract infection, including...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect many animal species, including minks, cats, and dogs. To gain insights into SARS-CoV-2 infections in cats dogs, we developed validated a set of serologic assays, ELISA virus neutralization. Evaluation samples from animals before they acquired disease roaming SARS-CoV-2-positive mink farms confirmed the suitability these assays for specific antibody detection. Furthermore, our findings exclude nucleocapsid protein as an...
Several domestic and wild animal species are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Reported (sero)prevalence in dogs cats vary largely depending on the target population, test characteristics, geographical location time period. This research assessed prevalence of SARS-CoV-2-positive (PCR- and/or antibody positive) two different populations. Dogs living a household with at least one confirmed COVID-19-positive person (household (HH) study; 156...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people globally since its first detection in late 2019. Besides humans, cats and, to some extent, dogs were shown be susceptible SARS-CoV-2, highlighting the need for surveillance a One Health context. Seven veterinary clinics from regions with high incidences disease (COVID-19) recruited during early pandemic (March July 2020) screening patients. A total 2257 oropharyngeal and nasal swab specimen 877 260...
Since the coronavirus disease (COVID-19) pandemic was first identified in early 2020, rare cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection pet cats have been reported worldwide. Some reports with SARS-CoV-2 showed self-limiting or gastrointestinal after suspected human-to-feline transmission via close contact humans SARS-CoV-2. In present study, we investigated a cat that presented to private animal clinic Northern Italy May 2020 weak clinical condition due an...
Assays to measure SARS-CoV-2-specific neutralizing antibodies are important monitor seroprevalence, study asymptomatic infections and reveal (intermediate) hosts. A recently developed assay, the surrogate virus-neutralization test (sVNT) is a quick commercially available alternative "gold standard" virus neutralization assay using authentic virus, does not require processing at BSL-3 level. The relies on inhibition of binding receptor domain (RBD) spike (S) protein human...
Animals like mink, cats and dogs are susceptible to SARS-CoV-2 infection. In the Netherlands, 69 out of 127 mink farms were infected with between April November 2020 all on culled after infection prevent further spread virus. On some farms, (feral) present. This study provides insight into prevalence positive in ten their possible role transmission Throat rectal swabs 101 (12 domestic 89 feral cats) 13 tested for using PCR. Serological assays performed serum samples from 62 adult dogs. Whole...
Due to the accelerated appearance of antimicrobial-resistant (AMR) pathogens in clinical infections, new first-in-class antibiotics, operating via novel modes action, are desperately needed. Brevicidine, a bacterial nonribosomally produced cyclic lipopeptide, has shown potent and selective antimicrobial activity against Gram-negative pathogens. However, before our investigations, little was known about how brevicidine exerts its bactericidal effect In this study, we find that AMR...
Apis cerana is an important pollinator of agricultural crops in China. In the environment, A. may be exposed to acetamiprid (neonicotinoid insecticide) and difenoconazole (triazole fungicide), alone or combination because they are commonly applied various crops. At present, our understanding toxicological effects on honey bee gut microbiomes limited. The primary objective this study was explore whether these two pesticides affect bees' microbiota analyze transcriptional head gut. study,...
After being discovered for the first time in China 2017, porcine reproductive and respiratory syndrome virus (PRRSV) NADC34-like strains have become prevalent strain of PRRSV certain regions China. Our previous study showed that reduced Ingelvac PRRS MLV vaccination dosages against NADC30-like CF had a better protection effect than normal dosage. However, protective is unclear. Therefore, this compared effectiveness 0.1 1 infection using commercial vaccines, MLV, which been widely utilized...
Porcine epidemic diarrhea virus (PEDV) is a major pathogen that causes serious economic losses to the swine industry. To aid PEDV clinical diagnosis and vaccine development, sensitive precise serological methods are demanded for rapid detection of (neutralizing) antibodies. Aiming development novel virus-free hemagglutination inhibition (HI) assay, N-terminal region S1 subunit, encompassing sialic acid-binding motif, was first expressed as an Fc-fusion protein with C-terminal Spy Tag...
The local connectivity and global position of a protein in interaction network are known to correlate with some its functional properties, including essentiality or dispensability. It is therefore interest extend this observation examine whether properties two proteins considered simultaneously can determine their joint dispensability, i.e., propensity for synthetic sick/lethal interaction. Accordingly, we the predictive power networks genetic Saccharomyces cerevisiae, an organism which high...
Coronaviruses (CoVs) are widespread among mammals and birds known for their potential cross-species transmission. In cats, infections with feline coronaviruses (FCoVs) common. Several non-feline have been reported to infect cells as well cats after experimental infection, supported by ability engage the receptor ortholog cell entry. However, whether might become naturally infected CoVs of other species is unknown. We analyzed coronavirus in serological monitoring. total 137 cat serum samples...
Pasteurella multocida, a zoonotic pathogen that produces 146-kDa modular toxin (PMT), causes progressive atrophic rhinitis with severe turbinate bone degradation in pigs. However, its mechanism of cytotoxicity remains unclear. In this study, we expressed PMT, purified it prokaryotic expression system, and found killed PK15 cells. The host factor CXCL8 was significantly upregulated among the differentially genes transcriptome sequencing analysis qPCR verification. We constructed...