A5020392820- Carcinogens and Genotoxicity Assessment
- Genomics and Phylogenetic Studies
- Effects and risks of endocrine disrupting chemicals
- Plant-Microbe Interactions and Immunity
- Animal Virus Infections Studies
- Liver Disease Diagnosis and Treatment
- Microbial infections and disease research
- Aquaculture disease management and microbiota
- Gut microbiota and health
- Identification and Quantification in Food
- Virus-based gene therapy research
- Animal testing and alternatives
- High Altitude and Hypoxia
- Plant tissue culture and regeneration
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Nerve injury and regeneration
- T-cell and B-cell Immunology
- RNA regulation and disease
- Circadian rhythm and melatonin
- Hemoglobinopathies and Related Disorders
- Immune Cell Function and Interaction
- Prenatal Screening and Diagnostics
- Plant Virus Research Studies
- Medicinal Plants and Bioactive Compounds
Sichuan Agricultural University
2011-2025
Tianjin Medical University
2025
Shanxi Agricultural University
2025
Tianjin Nankai Hospital
2025
Environmental Protection Agency
2010-2024
Dalian Medical University
2024
Children's Hospital of Chongqing Medical University
2019-2024
China International Science and Technology Cooperation
2021-2024
Chongqing Medical University
2016-2024
Xizang Minzu University
2023-2024
Based on existing data and previous work, a series of studies is proposed as basis toward pragmatic early step in transforming toxicity testing. These were assembled into data-driven framework that invokes successive tiers testing with margin exposure (MOE) the primary metric. The first tier integrates from high-throughput vitro assays, vitro-to-in vivo extrapolation (IVIVE) pharmacokinetic modeling, modeling. assays are used to separate chemicals based their relative selectivity interacting...
The number of legacy chemicals without toxicity reference values combined with the rate new chemical development is overwhelming capacity traditional risk assessment paradigm. More efficient approaches are needed to quantitatively estimate risks. In this study, rats were dosed orally multiple doses six for 5 days and 2, 4, 13 weeks. Target organs analyzed histological organ weight changes transcriptional using microarrays. Histological in study tumor incidences original cancer bioassays...
The traditional approach for estimating noncancer and cancer reference values in quantitative chemical risk assessment is time resource intensive. extent nature of the studies required under has limited number chemicals with published assessments. In this study, female mice were exposed 13 weeks to multiple concentrations five that positive a 2-year bioassay. Traditional histological organ weight changes evaluated, gene expression microarray analysis was performed on target tissues....
The rate of new chemical development in commerce combined with a paucity toxicity data for legacy chemicals presents unique challenge human health risk assessment. There is clear need to develop technologies and incorporate novel streams more efficiently inform derivation values. One avenue exploitation lies the field transcriptomics application gene expression analysis characterize biological responses exposures. In this context, set enrichment (GSEA) was employed evaluate tissue-specific,...
Intestinal microbiota composition plays a crucial role in modulating the health of host. This evaluation indicator is very sensitive and profoundly impacts protection endangered species. Currently, information on gut wild birds remains scarce. Therefore, this study aimed to describe microbial community structure potentially, pathogen Arborophila rufipectus.To guarantee comprehensive data analysis, we collected fecal samples from A. rufipectus Lophura nycthemera their habitats for two...
After being discovered for the first time in China 2017, porcine reproductive and respiratory syndrome virus (PRRSV) NADC34-like strains have become prevalent strain of PRRSV certain regions China. Our previous study showed that reduced Ingelvac PRRS MLV vaccination dosages against NADC30-like CF had a better protection effect than normal dosage. However, protective is unclear. Therefore, this compared effectiveness 0.1 1 infection using commercial vaccines, MLV, which been widely utilized...
ABSTRACT Porcine deltacoronavirus (PDCoV) is an enteric pathogen that burdens the global pig industry and a public health concern. The development of effective antiviral therapies necessary for prevention control PDCoV, yet to date, there are few studies on therapeutic potential PDCoV-neutralizing antibodies. Here, we investigate novel monoclonal antibody (mAb 4A6) which targets PDCoV S1 protein effectively neutralizes both pre- post-attachment cells, with IC50 values 0.537 8.487 µg/mL,...
Background Diabetes is a common metabolic disease that associated with gut microbiota dysbiosis and iron metabolism. Salidroside (SAL) the main ingredient of traditional Chinese herb Rhodiola, previous studies have shown SAL could reshape limit accumulation. Therefore, it possible can act as an alternative therapy for diabetes, its underlying mechanism worth exploring. Methods was used to treat diabetic db/db mice. Serum glucose levels histopathology myocardial fibres were evaluated. The...
// Han-Xue Li 1 , Xiao-Juan Fu Kai Yang Dan Chen Hong Tang Qin Zhao Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital Chongqing Medical University, 400016, China Correspondence to: Yang, e-mail: cqfyyk@hotmail.com Keywords: oral cancer, tumor, circadian clock, PER1, tumor-related genes Received: October 11, 2015 Accepted: February 20, 2016 Published: March 01, ABSTRACT Abnormal expression the clock gene PER1 is highly correlated with carcinogenesis development...
The kidney is a major site of chemical excretion, which results in its propensity to exhibit chemically-induced toxicological effects at higher rate than most other organs. Although the kidneys are often weighed animal toxicity studies, manner these weight measurements interpreted and value this information predicting renal damage remains controversial. In study we sought determine whether relationship exists between changes histopathological alterations. We also examined relative utility...
Wallerian degeneration is a subject of major interest in neuroscience. A large number genes are differentially regulated during the distinct stages degeneration: transcription factor activation, immune response, myelin cell differentiation and dedifferentiation. Although gene expression responses distal segment sciatic nerve after peripheral injury known, differences between proximal segments remain unclear. In present study rats, we used microarrays to analyze changes expression, biological...
Porcine reproductive and respiratory syndrome virus (PRRSV) poses a severe threat to the health of pigs globally. Host factors play critical role in PRRSV replication. Using as model for genome-scale CRISPR knockout (KO) screening, we identified host factor infection: sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B). Our findings show that SMPDL3B restricted attachment, entry, replication, secretion its depletion significantly inhibited proliferation, indicating plays positive data...
Sepsis-induced acute lung injury (ALI) accounts for about 40% of ALI, accompanied by alveolar epithelial injury. The study aimed to reveal the role circular RNA_0114428 (circ_0114428) in sepsis-induced ALI. Human pulmonary cells (HPAEpiCs) were treated with lipopolysaccharide (LPS) mimic a ALI cell model. RNA expression circ_0114428, miR-574-5p and Rho-associated coiled-coil containing protein kinase 2 (ROCK2) was detected qRT-PCR. Protein checked Western blotting. Cell viability,...