A5101564448- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Glutathione Transferases and Polymorphisms
- Retinoids in leukemia and cellular processes
- RNA Interference and Gene Delivery
- Quinazolinone synthesis and applications
- Genomics, phytochemicals, and oxidative stress
- Plant biochemistry and biosynthesis
- Milk Quality and Mastitis in Dairy Cows
- Heme Oxygenase-1 and Carbon Monoxide
- Light effects on plants
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Estrogen and related hormone effects
- Circadian rhythm and melatonin
- Glaucoma and retinal disorders
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Viral-associated cancers and disorders
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Plant Gene Expression Analysis
Chinese People's Liberation Army
2023
Jiangsu Cancer Hospital
2015-2022
Nanjing Medical University
2012-2022
Nanjing Agricultural University
2021
Central South University
2008-2020
West China Medical Center of Sichuan University
2020
Hebei Medical University
2020
Second Hospital of Hebei Medical University
2020
Nanjing University
2012-2019
Chongqing Medical University
2015-2019
Recent studies showed that lncRNA CASC9 was upregulated and acted as an oncogene in a variety of tumors. However, the expression biological functions oral squamous cell carcinoma (OSCC) remain unknown. In this study, we found for first time remarkably OSCC tissues lines compared with paired noncancerous normal epithelial cells. Highly expressed is strongly associated tumor size, clinical stage, regional lymph node metastasis overall survival patients. vitro, knockdown cells SCC15 CAL27...
MicroRNAs are small non-coding RNA molecules that important regulators of gene expression at the post-transcriptional level. miRNAs impact processes cell proliferation, differentiation and apoptosis. Thus, regulation miRNA profiles associated with mastitis will be conducive for its control. In this study, Staphylococcus aureus (S. aureus) was administered to mammary gland Chinese Holstein cows construct a bacteria-type model. Total isolated from bovine tissue samples S. aureus-induced group...
Nasopharyngeal carcinoma (NPC) is among the most common squamous cell in South China and Southeast Asia. Radiotherapy primary treatment for NPC. However, radioresistance acts as a significant factor that limits efficacy of radiotherapy NPC patients. Growing evidence supports microRNAs (miRNAs) play an important role radiation response. Real-time quantitative PCR was used to analyze expression miR-19b-3p lines NP69. profiles tissues were obtained from Gene Expression Omnibus database. The...
Background Abnormal activity of STAT3 is associated with a number human malignancies. Hsp90 plays central role in stabilizing newly synthesized proteins and participates maintaining the functional competency signaling transducers involved cell growth, survival oncogenesis, such as STAT3. interacts stabilizes Tyr-phosphorylated It has been reported that luteolin possesses anticancer through degradation Tyr705-phosphorylated Methodology/Principal Findings We found overexpression inhibited...
This study aimed to describe the expression profiles of microRNAs (miRNAs) from mammary gland tissues collected dairy cows with Streptococcus agalactiae-induced mastitis and identify differentially expressed miRNAs related mastitis. The glands Chinese Holstein were challenged agalactiae induce Small RNAs isolated test control groups then sequenced using Solexa sequencing technology construct two small RNA libraries. Potential target genes these predicted RNAhybrid software, KEGG pathways...
// Han-Xue Li 1 , Xiao-Juan Fu Kai Yang Dan Chen Hong Tang Qin Zhao Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital Chongqing Medical University, 400016, China Correspondence to: Yang, e-mail: cqfyyk@hotmail.com Keywords: oral cancer, tumor, circadian clock, PER1, tumor-related genes Received: October 11, 2015 Accepted: February 20, 2016 Published: March 01, ABSTRACT Abnormal expression the clock gene PER1 is highly correlated with carcinogenesis development...
The proliferation and migration of vascular endothelial cells (VECs) plays a vital role in angiogenesis, process that influences plaque vulnerability human atherosclerosis. Luteolin is type flavonoid has shown positive effect on the morbidity mortality cardiovascular diseases. However, it remains unclear whether this compound protective against umbilical vein (HUVECs) induced by angiotensin II (AngII). HUVECs were treated with different concentrations luteolin for varying lengths time....
Ursodeoxycholic acid (UDCA) is widely used to treat chronic liver diseases, and its cytoprotective effect on normal hepatocytes has been shown. This study aimed investigate the apoptotic effects of UDCA hepatocellular carcinoma (HCC) cells underlying molecular events in vitro.HCC were treated by at different doses periods time assess cell morphology, viability, apoptosis gene expression using methyl thiazolyl tetrazolium (MTT), Annexin V/propidium iodide (PI) stain, transferase dUTP nick end...
Background: Usnic Acid (UA), also known as lichenol, has been reported to have inhibitory effects on a variety of cancer cells, but its specific mechanism remained be elucidated. Tumor chemotherapy drugs, especially DNA damage chemotherapeutic target Chromosomal DNA, their spontaneous and acquired drug resistance are an urgent problem solved. Therefore, combination research become the focus researchers. Methods: Here, we evaluated tumor-suppressing molecular UA in colorectal cells RKO from...
Background: Glaucoma is a multifactorial optic neuropathy progressively characterized by structural loss of Retinal Ganglion Cells (RGCs) and irreversible vision. High Intraocular Pressure (HIOP) high-risk factor for glaucoma. It has been reported that the mechanisms RGCs are explored in-depth after acute HIOP injury, such as apoptosis, autophagy, necrosis. However, pyroptosis, novel type pro-inflammatory cell programmed necrosis, rarely injury. Research studies also showed melatonin (MT)...
To visualize completely rat retinal microvessels, the gelatin-ink perfusion condition was systematically optimized using von Willebrand factor (vWf) immunostaining as control. Whether vessel showed by new can be used for double label with neurons or glial cells in same retina also tested. Our results that infusing rats first 20 ml of 37°C ink plus 3% gelatin at 140% mean arterial pressure (MAP), and subsequently 5% 180% MAP allowed to fill microvessels. Rat microvessels labeled method were...
Cisplatin-based chemotherapy is the standard treatment for non-small cell lung cancer (NSCLC). However, drug resistance emergences after treatment. Long non-coding RNA microvascular invasion in hepatic (MVIH) plays an important role a variety of cancers. This study investigates nedaplatin on multidrug NSCLC and its relationship with MVIH. Lung A549 H1650 cells were treated cisplatin to obtain multidrug-resistant A549/DDP H1650/ DDP cells. nedaplatin, MVIH siRNA NC. It was found that both...
Adriamycin is a novel chemotherapeutic agent of great benefit for treating breast cancer. However, adriamycin -resistance remains major obstacle. The vital Glutathione transferase P1 (GSTPi) inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol (NBDHEX) has recently shown antitumor activity in various cancers. In this study, we analyzed the effect NBDHEX and combination against cancer vitro vivo.CCK-8 assay was performed to test cell viability. location expression level GSTpi determined...
Abstract Background Cationic polymers are outstanding representatives of the most efficient small interfering RNA (siRNA) vectors. Low cytotoxicity and siRNA protecting effect can be obtained with these cationic via a variety structural modifications. Nevertheless, gap between their efficiency requirement for therapeutic processes is still noticeable. Methods A polymer vector was synthesized copolymerization N ‐(1,3‐dihydroxy propan‐2‐yl)methacrylamide (DHPMA) ‐(3‐aminopropyl)methacrylamide...
iASPP is an inhibitory member of the apoptosis-stimulating proteins P53 (ASPP) family. over expressed in several malignant tumors and potentially affects cancer progression. However, expression potential role oral tongue squamous cell carcinoma (OTSCC) have not been addressed. In our study, we detected OTSCC by immunohistochemistry. up-regulated tissues. Moreover, clinical pathology specimens, found that increased correlates with poor differentiation lymph node metastasis. Using...