A5017530942- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Intensive Care Unit Cognitive Disorders
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Anesthesia and Sedative Agents
- Glutathione Transferases and Polymorphisms
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Cancer Immunotherapy and Biomarkers
- Mast cells and histamine
- Toxin Mechanisms and Immunotoxins
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Pain Mechanisms and Treatments
- S100 Proteins and Annexins
- PARP inhibition in cancer therapy
- Hereditary Neurological Disorders
- Pancreatic and Hepatic Oncology Research
Jiangsu Cancer Hospital
2016-2023
Nanjing Medical University
2016-2023
Jiangsu Province Hospital
2020-2022
Second Affiliated Hospital of Nanjing Medical University
2018
Nanjing Drum Tower Hospital
2017
Neuroinflammation contributes to or even causes central nervous system (CNS) diseases, and its regulation is thus crucial for brain disorders. Mast cells (MCs) microglia, two resident immune in the brain, together with astrocytes, play critical roles progression of neuroinflammation-related diseases. MCs have been demonstrated as one fastest responders, they release prestored newly synthesized mediators including histamine, β -tryptase, heparin. However, temporal changes MC activation this...
Abstract Objective Neuroinflammation plays a critical role in central nervous system diseases. Exosomal miRNAs released from various cells are implicated cell-to-cell communication. Prior studies have placed substantial emphasis on the of cytokines mast cell-microglia interactions during neuroinflammation. However, it has never been clearly determined whether exosomal participate interaction between and microglia thus mediate Methods The characteristics exosomes isolated cell culture...
Background: The pathophysiological mechanisms underlying postoperative cognitive dysfunction (POCD) remain unclear over the years. Neuroinflammation caused by surgery has been recognized as an important element in development of POCD. Many studies also suggest that vagus nerve plays role transmitting peripheral injury signals to central nervous system (CNS) and resultant neuroinflammation. Previously, we have demonstrated brain mast cells (BMCs), "first responders", play a vital...
Abstract Most of the patients with lung cancer are diagnosed at advanced stage, and they often lose opportunity surgical therapy, most whom fail to reach good prognosis after chemotherapy. Recently, a few clinical studies have confirmed role adoptive T-cell transfer in maintenance therapy patients. Here, we provided statistical insights into CIKs from three different levels, cell model (in vitro co-culture system), mice situ cancer), research progression stages). We optimized components...
Abstract Background Microglia, the principal sentinel immune cells of central nervous system (CNS), play an extensively vital role in neuroinflammation and perioperative neurocognitive disorders (PND). Histamine, a potent mediator inflammation, can both promote prevent microglia-related by activating different histamine receptors. Rat microglia express four receptors (H1R, H2R, H3R, H4R), among which 1 4 activation, whereas cellular mechanism 2 3 have not been elucidated. Therefore, we...
Some research found that elevated plasma cell-free DNA (cfDNA) concentrations and poor prognosis are associated in non-small cell lung cancer (NSCLC). However, more studies need to be carried out verify this conclusion. Therefore, study investigated the relationship between cfDNA concentration treatment outcomes including patients with advanced NSCLC.We retrospectively collected medical records data from 160 NSCLC. Progression-free survival (PFS) were calculated using Kaplan-Meier method...
Piwi-Interacting RNA (piRNA) is the largest class of small noncoding and involved in various physiological pathological processes. However, whether it has a role pain modulation remains unknown. In present study, we found that spinal piRNA-DQ541777 (piR-DQ541777) was significantly increased male mouse model sciatic nerve chronic constriction injury (CCI)-induced neuropathic pain. Knockdown piR-DQ541777 alleviated CCI-induced thermal hyperalgesia mechanical allodynia neuronal sensitization....
To understand the mechanism involved in gefitinib resistance, we established gefitinib-resistant human HCC827/GR-8-1 cell line from parental HCC827 line. We compared micro-RNA expression profiles of cells using Agilent microarrays. The micro-RNAs, such as miR-149-5p, were up- or downregulated and associated with acquired resistance. Quantitative real-time polymerase chain reaction was then performed to verify patterns different micro-RNAs. result showed that miR-149-5p upregulated...
Background: Ketamine disrupts the proliferation and differentiation of developing neural stem cells (NSCs). Therefore, safe use ketamine in pediatric anesthesia has been an issue increasing concern among anesthesiologists children's parents. Dexmedetomidine (DEX) is widely used sedation as antianxiety agent for analgesia. DEX recently shown to provide neuroprotection against anesthetic-induced neurotoxicity brain. The aim this vivo study was investigate whether exerted neuroprotective...
The recent research shows that the inhibition of nuclear factor-κB (NF-κB) pathway is a promising therapeutic option for patients who progress after treatment with novel mutant-selective EGFR-TKIs. For propose to find nontoxic drug reverse acquired gefitinib resistance, we examined whether Liver X Receptors agonist GW3965 affect resistance HCC827/GR-8-2 cells. Cell viability was measured by CCK-8 assay. Levels NF-κB, p-AKT and caspases were detected Western blot analysis. Immunocytochemical...