A5101536979- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- Microbial Community Ecology and Physiology
- Microbial Metabolism and Applications
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Analysis
- RNA modifications and cancer
- Extracellular vesicles in disease
- Enzyme Production and Characterization
- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Cancer Cells and Metastasis
- Electron Spin Resonance Studies
- Aquaculture disease management and microbiota
- Identification and Quantification in Food
- Actinomycetales infections and treatment
- Breast Cancer Treatment Studies
- Plant Disease Resistance and Genetics
- Pharmacological Effects of Natural Compounds
- Cancer-related Molecular Pathways
- Biological Activity of Diterpenoids and Biflavonoids
- Curcumin's Biomedical Applications
Nanjing Medical University
2015-2024
Kunming University
2017-2024
Jiangsu Province Hospital
2016-2024
Anhui Medical University
2022-2024
Yunnan University
2013-2023
Nantong University
2023
Affiliated Hospital of Nantong University
2023
Fuyang City People's Hospital
2023
State Key Laboratory of Reproductive Medicine
2022
Jiangxi Agricultural University
2022
Breast cancer (BCa) is one of the major deadly cancers in women. However, treatment BCa still hindered by acquired-drug resistance. It increasingly reported that exosomes take part development, metastasis, and drug resistance BCa. specific role poorly understood. In this study, we investigate whether transmit through delivering miR-222. We established an adriamycin-resistant variant Michigan Cancer Foundation-7 (MCF-7) breast cell line (MCF-7/Adr) from a drug-sensitive (MCF-7/S). Exosomes...
// Shanliang Zhong 1 , Xiu Chen 2 Dandan Wang Xiaohui Zhang Hongyu Shen Sujin Yang Mengmeng Lv Jinhai Tang Jianhua Zhao Center of Clinical Laboratory Science, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, 210009, China Department General Surgery, Correspondence to: Zhao, e-mail: seuzsl@163.com jhzhao2838@sina.com Keywords: microvesicles, breast, cancer, chemoresistance, microRNA Received: December 02, 2015 Accepted: February 11, 2016 Published: 18, ABSTRACT Exosomes have...
Aim: Aerobic glycolysis is characteristic of breast cancer. Comprehensive expression profiles key proteins, their prognosis and detailed relationships between miRNAs mRNAs remain unclear. Materials & methods: Oncomine database, Kaplan-Meier overall survival miRNA-mRNA network analysis were performed. A miRNA was identified explored in vitro vivo. Results conclusion: Eleven glycolytic proteins found with higher poor prognosis: GLUT1, SLC2A5, HK1, PFKP, ALDOA, TPI1, GAPDH, PGK1, ENO1, GOT1...
Ginsenosides, the active ingredients extracted from Panax ginseng , have been shown to promote nitric oxide (NO) release in bovine aortic endothelial cells. Since cells and perivascular nerves penile corpus cavernosum contain NO synthase an NO‐like substance has be released these which relaxes cavernosum, possibility that ginsenosides may relax by releasing endogenous was examined. With vitro tissue superfusion technique, (250, 500 750 μg ml −1 ) relaxed concentration‐dependently. Using bath...
Abstract In many tissues, two or more types of stem cells share a niche, and how the coordinate their self‐renewal differentiation is poorly understood. Drosophila testis, germ line (GSCs) somatic cyst progenitor (CPCs) contact each other niche (the hub). The hub expresses growth factor unpaired (Upd) that activates Janus kinase/signal transducer activator transcription (JAK/STAT) pathway in GSCs to regulate cell self‐renewal. Here, we demonstrate JAK/STAT signaling also regulates CPCs We...
We studied the actions of saponin (ginsenosides) from Panax ginseng on free radical-induced pulmonary endothelial injury which is manifest as reversal normal vasodilator response to acetylcholine in perfused, vasoconstricted lungs. 50 or 200 μg/ml ginsenosides prevented this and also reduced edema follows radical but did not alter ACh — induced vasodilation intact In control perfused lungs preconstricted with U46619, ginsenoside mixture purified Rb1 Rg1 caused vasodilatation. This effect was...
Background/Aims: Emerging evidence suggests that curcumin possesses chemopreventive properties against various cancers. However, its poor bioavailability limits clinical application. In this study, we aimed to utilize encapsulation in liposomes (Lipo) as a strategy for the administration of endometrial carcinoma (EC). Methods: Curcumin was encapsulated liposomal delivery system prepare formulation (LC). EC cell lines Ishikawa and HEC-1 were treated with compound proliferation measured using...
The study aimed to investigate the role of circular RNA circASS1 in breast cancer cells.Circular RNAs microarray expression profile were analyzed MCF-7, MDA-MB-231, and qRT-PCR western blotting used quantify its parental gene ASS1. Wound healing, migration invasion assay performed. Luciferase system was detect harbored miRNA.CircASS1 MDA-MB-231 is downregulated comparing overexpression could suppress migration. While silence, it promote MiR-4443 functioning as a tumor promoter be captured by...
The metastasis of breast cancer (BC) is a complex multi-step pathological process, strictly dependent on the intrinsic characteristics BC cells and promoted by predisposing microenvironment. Although immunotherapy has made important progress in BC, heterogeneity PD-L1 tumor associated macrophages (TAMs) underlying mechanisms development are still not completely elucidated. Small extracellular vesicles (sEVs) represent essential interaction mediators between TAMs. It worth noting to explore...
Magnetically induced self-assembly technology was used to construct a label-free electrochemical biosensor based on magnetic Mg0.5Cu0.5Fe2O4-Au nanocomposites for the sensitive detection of cancer antigen 125 (CA125). To aim this, Mg0.5Cu0.5Fe2O4 nanoparticles were first prepared via rapid combustion process. The average diameter calcined at 800 °C with absolute ethanol volume 20 mL about 169.3 nm. Then Au surface modification by NaBH4 reduction reaction approach. glassy carbon electrode...