A5050173341- Cardiac Fibrosis and Remodeling
- Signaling Pathways in Disease
- Congenital heart defects research
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Tissue Engineering and Regenerative Medicine
- NF-κB Signaling Pathways
- Cardiac Ischemia and Reperfusion
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cytokine Signaling Pathways and Interactions
- Aortic aneurysm repair treatments
- Cancer-related molecular mechanisms research
- Acute Kidney Injury Research
- Cardiac Arrest and Resuscitation
- MicroRNA in disease regulation
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Drug Transport and Resistance Mechanisms
- Mitochondrial Function and Pathology
- Immune Response and Inflammation
- Cholesterol and Lipid Metabolism
- Cancer, Hypoxia, and Metabolism
- Acute Myocardial Infarction Research
Army Medical University
2010-2023
Daping Hospital
2013-2023
Yanshan University
2023
Nanjing Medical University
2013-2021
University of Nevada, Reno
2013-2017
Temple University
2013-2017
Center for Excellence in Molecular Cell Science
2017
Shanghai Institutes for Biological Sciences
2017
University of Chinese Academy of Sciences
2017
Wuhan University
2014
Adult mammalian hearts have a limited ability to generate new cardiomyocytes. Proliferation of existing adult cardiomyocytes (ACMs) is potential source Understanding the fundamental biology ACM proliferation could be great clinical significance for treating myocardial infarction (MI). We aim understand process and regulation its role in cardiomyocyte formation post-MI mouse hearts.β-Actin-green fluorescent protein transgenic mice fate-mapping Myh6-MerCreMer-tdTomato/lacZ were used trace fate...
Background Recent studies have demonstrated that transplantation of adipose-derived stem cell (ADSC) can improve cardiac function in animal models myocardial infarction (MI). However, the mechanisms underlying beneficial effect are not fully understood. In this study, we characterized paracrine transplanted ADSC and investigated its relative importance versus direct differentiation mediated repair. Methodology/Principal Findings MI was experimentally induced mice by ligation left anterior...
Mitochondrial (mt) dysfunction and oxidative stress are involved in the pathogenesis of ischemia/reperfusion (I/R)-injury. Lycopene, a lipophilic antioxidant found mainly tomatoes other vegetables fruits, can protect mtDNA against damage. However, role myocardial I/R-injury is unclear. In present study, we aimed to determine if how lycopene protects cardiomyocytes from I/R-injury. both vitro vivo studies, increased mt 8-hydroxyguanine (8-OHdG) content, decreased content transcription levels,...
Transplantation of stem cells into damaged hearts has had modest success as a treatment for ischemic heart disease. One the limitations is poor cell survival in diseased microenvironment. Prolyl hydroxylase domain protein 2 (PHD2) cellular oxygen sensor that regulates key transcription factors involved and inflammation: hypoxia-inducible factor nuclear factor-κB.We studied whether how PHD2 silencing human adipose-derived (ADSCs) enhances their cardioprotective effects after transplantation...
Interferon regulatory factor 1 (IRF1), a critical member of the IRF family, was previously shown to be associated with immune system and involved in apoptosis tumor suppression. However, role IRF1 pressure overload-induced cardiac remodeling has remained unclear. Using genetic approaches, we established central for transcription regulation both vivo vitro, determined mechanism underlying this process. The expression level remarkably altered failing human hearts hypertrophic murine hearts....
After myocardial infarction (MI), the heart is difficult to repair because of great loss cardiomyoctyes and lack cardiac regeneration. Novel drug candidates that aim at reducing pathological remodeling stimulating regeneration are highly desirable. In present study, we identified if how a novel porcupine inhibitor CGX1321 influenced MI Permanent ligation left anterior descending (LAD) coronary artery was performed in mice induce injury. Cardiac function measured by echocardiography, infarct...
ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) is recognized as a metalloproteinase that promotes the cleavage of amino propeptides types I, II, III, V procollagens. However, role in heart has not yet been defined. Herein, we observed upregulated expression failing human hearts hypertrophic murine hearts. Mice lacking display exacerbated cardiac hypertrophy on pressure overload–induced response, whereas mice with cardiac-specific overexpression alleviation this...
G protein-coupled receptor kinase 4 (GRK4) has been reported to play an important role in hypertension, but little is known about its cardiomyocytes and myocardial infarction (MI). The goal of present study explore the GRK4 pathogenesis progression MI.
We set out to investigate whether and how SRY (sex-determining region, Y) DNAs in plasma EVs (extracellular vesicles) is involved the pathogenesis of atherosclerosis. PCR gene sequencing found fragment from male, but not female, patients; male patients with CAD (coronary artery disease) had a higher GCN (gene copy number) than healthy subjects. Additional studies that leucocytes, major source EVs, mRNA protein expression controls. After incubation SRY-transfected HEK (human embryonic...
Infection is thought to be involved in the pathogenesis of atherosclerosis. Studies have shown association between helicobacter pylori (H. pylori) and coronary artery disease. It interesting find H. DNA cytotoxin-associated gene A (CagA) protein atherosclerotic plaque. Outer membrane vesicles (OMVs), secreted by pylori, exert effects distant organ or tissue. However, whether not OMVs from are atherosclerosis remains unknown. Our present study found that treatment with CagA-positive...
Caspase recruitment domain 6 (CARD6), a crucial member of the CARD family, was initially shown to be involved in immune system and oncogenesis. However, role CARD6 chronic pressure overload-induced cardiac hypertrophy remains unexplored. To evaluate impact on pathological hypertrophy, cardiac-specific knockout mice transgenic with overexpression were generated subjected aortic banding for 4 weeks. Our results demonstrated that CARD6-deficient aggravated banding-triggered ventricular...
The mechanisms responsible for the postnatal loss of mammalian cardiac regenerative capacity are not fully elucidated. aim present study is to investigate role progesterone in regeneration and explore underlying mechanism.Effect on cardiomyocyte proliferation was analysed by immunofluorescent staining. RNA sequencing performed screen key target genes progesterone, yes-associated protein (YAP) knocked down demonstrate its pro-proliferative effect progesterone. Effect activity YAP promoter...
Aims Atherosclerosis is a public health concern affecting many worldwide, but its pathogenesis remains unclear. In this study we investigated the role of IKKε during formation atherosclerosis and molecular mechanism in mouse aortic vessel wall. Methods Results C57BL/6 wild-type or knockout mice bred into ApoE genetic background were divided 4 groups: (1) (WT), (2) (AK), (3) (IK), (4) both (DK). Each group fed with high fat diet (HFD) for 12 weeks from 8 age. Immunohistochemistry Western...
The aim of this study was to observe macrophage infiltration in congenital bicuspid aortic valve (CBAV) stenosis. M1/M2 distribution, inflammatory cytokine expression and the role M1 macrophages during CBAV stenosis were also explored. experimental control groups comprised 30 severely stenotic CBAVs tricuspid valves (TAVs), respectively. Histological morphological changes assessed using hematoxylin-eosin (HE) staining mRNA levels vascular endothelial growth factor (VEGF) examined...