A5100672327- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Nitric Oxide and Endothelin Effects
- Ion Transport and Channel Regulation
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
- Eicosanoids and Hypertension Pharmacology
- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
- Receptor Mechanisms and Signaling
- Signaling Pathways in Disease
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Coronary Interventions and Diagnostics
- Mitochondrial Function and Pathology
- Acute Myocardial Infarction Research
- Extracellular vesicles in disease
- Vascular Procedures and Complications
- Acute Kidney Injury Research
- Mesenchymal stem cell research
- Pancreatic function and diabetes
- Cardiac Imaging and Diagnostics
- Metabolism, Diabetes, and Cancer
- Sodium Intake and Health
Daping Hospital
2016-2025
Army Medical University
2016-2025
University of Chinese Academy of Sciences
2017-2024
Ministry of Education of the People's Republic of China
2023-2024
Central South University
2023
Fujian Medical University
2020-2021
George Washington University
2010-2021
Union Hospital
2020-2021
BGI Group (China)
2021
Dalian Medical University
2019
Adult mammalian hearts have a limited ability to generate new cardiomyocytes. Proliferation of existing adult cardiomyocytes (ACMs) is potential source Understanding the fundamental biology ACM proliferation could be great clinical significance for treating myocardial infarction (MI). We aim understand process and regulation its role in cardiomyocyte formation post-MI mouse hearts.β-Actin-green fluorescent protein transgenic mice fate-mapping Myh6-MerCreMer-tdTomato/lacZ were used trace fate...
Abstract Background Diabetic cardiomyopathy (DCM) is a serious complication in patients with type 1 diabetes mellitus (T1DM), which still lacks adequate therapy. Irisin, cleavage peptide off fibronectin III domain-containing 5, has been shown to preserve cardiac function ischemia–reperfusion injury. Whether or not irisin plays cardioprotective role DCM known. Methods and results T1DM was induced by multiple low-dose intraperitoneal injections of streptozotocin (STZ). Our current study showed...
Irisin protects against ischemia/reperfusion injury to the lung by improving mitochondrial function.
In the failing heart, persistent β-adrenergic receptor activation is thought to induce myocyte death by protein kinase A (PKA)-dependent and PKA-independent of calcium/calmodulin-dependent II. signaling pathways also are capable activating cardioprotective mechanisms.This study used a novel PKA inhibitor peptide inhibit activity test hypothesis that causes cell through PKA-dependent cardioprotection pathways.In transgenic mice, chronic isoproterenol failed cardiac hypertrophy, fibrosis,...
Background Recent studies have demonstrated that transplantation of adipose-derived stem cell (ADSC) can improve cardiac function in animal models myocardial infarction (MI). However, the mechanisms underlying beneficial effect are not fully understood. In this study, we characterized paracrine transplanted ADSC and investigated its relative importance versus direct differentiation mediated repair. Methodology/Principal Findings MI was experimentally induced mice by ligation left anterior...
Background Exercise is a major nonpharmacological treatment for hypertension, but its underlying mechanisms are still not completely elucidated. Irisin, polypeptide containing 112 amino acids, which secreted mainly by skeletal muscle cells during exercise, exerts protective role in metabolic diseases, such as diabetes mellitus and obesity. Because of the close relationship between irisin we hypothesized that may play regulation blood pressure. Methods Results Blood pressures male...
Recombinant MG53 translocates to sites of injury in the proximal tubule kidney and protects mice from acute induced by ischemia or drugs.
Abstract: Irisin, a muscle-origin protein derived from the extracellular domain of fibronectin domain-containing 5 (FNDC5), has been shown to modulate mitochondria welfare through paracrine action. Here, we test hypothesis that irisin contributes cardioprotection after myocardial infarction by preserving mitochondrial function in cardiomyocytes. Animal model studies show intravenous administration exogenous produces dose-dependent protection against ischemia/reperfusion (I/R)-induced injury...
Both oxidative stress and inflammation are involved in the pathogenesis of contrast-induced nephropathy (CIN). Epigallocatechin-3-gallate (EGCG), a purified catechin from green tea, has antioxidant anti-inflammatory effects. However, it is unknown whether or not EGCG effective treating CIN. Our present study found that intravenous administration EGCG, either before just after establishment CIN, had protective effect, determined by normalization serum creatinine blood urea nitrogen levels,...
Mitochondrial (mt) dysfunction and oxidative stress are involved in the pathogenesis of ischemia/reperfusion (I/R)-injury. Lycopene, a lipophilic antioxidant found mainly tomatoes other vegetables fruits, can protect mtDNA against damage. However, role myocardial I/R-injury is unclear. In present study, we aimed to determine if how lycopene protects cardiomyocytes from I/R-injury. both vitro vivo studies, increased mt 8-hydroxyguanine (8-OHdG) content, decreased content transcription levels,...
Heart failure (HF) is among the leading causes of morbidity and mortality, its prevalence continues to rise. LARP7 (La ribonucleoprotein domain family member 7) a master regulator that governs DNA damage response RNAPII (RNA polymerase II) pausing pathway, but role in HF pathogenesis incompletely understood. We assessed expression human nonhuman primate mouse models. To study function heart, we generated global cardiac-specific knockout mice. acutely abolished mature cardiomyocytes by...
Abstract Pro-inflammatory activation of adipose tissue macrophages (ATMs) is causally linked to obesity and obesity-associated disorders. A number studies have demonstrated the crucial role mitochondrial metabolism in macrophage activation. However, there a lack pharmaceutical agents target ATMs for treatment obesity-related diseases. Here, we characterize near-infrared fluorophore (IR-61) that preferentially accumulates mitochondria has therapeutic effect on diet-induced as well insulin...
Cellular senescence is associated with pleiotropic physiopathological processes, including aging and age-related diseases. The persistent DNA damage a major stress leading to senescence, but the underlying molecular link remains elusive. Here, we identify La Ribonucleoprotein 7 (LARP7), 7SK RNA binding protein, as an antagonist. damage-mediated Ataxia Telangiectasia Mutated (ATM) activation triggers extracellular shuttling downregulation of LARP7, which dampens SIRT1 deacetylase activity,...
Transplantation of stem cells into damaged hearts has had modest success as a treatment for ischemic heart disease. One the limitations is poor cell survival in diseased microenvironment. Prolyl hydroxylase domain protein 2 (PHD2) cellular oxygen sensor that regulates key transcription factors involved and inflammation: hypoxia-inducible factor nuclear factor-κB.We studied whether how PHD2 silencing human adipose-derived (ADSCs) enhances their cardioprotective effects after transplantation...
Our previous study showed that besides mRNAs and microRNAs, there are DNA fragments within extracellular vesicles (EVs). The BCR/ABL hybrid gene, involved in the pathogenesis of chronic myeloid leukemia (CML), could be transferred from K562 EVs to neutrophils decrease their phagocytic activity vitro. present provides evidence DNAs have pathophysiological significance vivo. Two months after injection into tail vein Sprague-Dawley (SD) rats, they some characteristics CML, e.g., feeble,...