A5018144456- Acute Kidney Injury Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Lipoproteins and Cardiovascular Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Renal and related cancers
- Sepsis Diagnosis and Treatment
- Diet and metabolism studies
- Cardiac Ischemia and Reperfusion
- Acute Ischemic Stroke Management
- Bariatric Surgery and Outcomes
- Diabetes Management and Research
- Neurological Disease Mechanisms and Treatments
- Dialysis and Renal Disease Management
- Folate and B Vitamins Research
- Renal Diseases and Glomerulopathies
- Advanced Glycation End Products research
- Cardiovascular Health and Disease Prevention
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diet, Metabolism, and Disease
- Parathyroid Disorders and Treatments
- Cardiac Arrest and Resuscitation
Nanjing Medical University
2016-2025
Shenzhen Second People's Hospital
2020-2025
Shenzhen Sixth People's Hospital
2021-2024
Xuzhou Medical College
2001-2024
Huaian First People’s Hospital
2021-2024
Shenzhen University
2024
Fudan University
2003-2023
Huashan Hospital
2022-2023
ShenZhen People’s Hospital
2023
Sir Run Run Shaw Hospital
2019
Abstract Objective Current literature is deficient in robust evidence delineating the correlation between triglyceride glucose-body mass index (TyG-BMI) and incidence of stroke. Consequently, this investigation seeks to elucidate potential link TyG-BMI stroke risk a cohort middle-aged senior Chinese individuals. Methods This study employs longitudinal data from four waves China Health Retirement Longitudinal Study (CHARLS) conducted 2011, 2013, 2015, 2018, encompassing 8,698 participants....
The atherogenic index of plasma (AIP) can reflect the burden atherosclerosis. Hyperglycemia is one leading causes However, relationship between AIP and prediabetes rarely studied. Therefore, we aimed to explore prediabetes.This retrospective cohort study recruited 100,069 Chinese adults at Rich Healthcare Group from 2010 2016. was calculated according Log10 (triglyceride/high-density lipoprotein cholesterol) formula. Cox regression method, sensitivity analyses subgroup were used examine...
Background The cardiometabolic index (CMI) has been proposed as a novel indicator of status. However, evidence on the relationship between CMI and diabetes mellitus (DM) risk was limited. Our study aimed to explore DM among large cohort Japanese adults. Methods This retrospective recruited 15453 adults without at baseline who underwent physical examinations Murakami Memorial Hospital 2004 2015. Cox proportional-hazards regression applied evaluate independent diabetes. performed generalized...
Background Clear cell renal carcinoma (ccRCC) is a malignant urogenital cancer with high mortality; however, current progress in understanding its molecular mechanism and predicting clinical treatment outcome limited. Therefore, this study to evaluate the significance of immune inhibitory human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2) ccRCC prognosis transcriptional regulatory network. Methods Expression HHLA2 was examined by an online database platform...
Rationale: Neprilysin (NEP) is a major endogenous catabolic enzyme of amyloid β (Aβ). Previous studies have suggested that increasing NEP expression in animal models Alzheimer's disease had an ameliorative effect. However, the underlying signaling pathway regulates remains unclear. The aryl hydrocarbon receptor (AhR) ligand-activated cytoplasmic and transcription factor. Recent shown AhR plays essential roles central nervous system (CNS), but its physiological pathological regulating are not...
Abstract Background By identifying individuals at high risk for non-alcoholic fatty liver disease (NAFLD), interventional programs could be targeted more effectively. Some studies have demonstrated that triglyceride glucose-body mass index (TyG-BMI) showed an independent positive association with NAFLD. However, research on its diagnostic value in patients suspected NAFLD is limited. In this study, we aimed to evaluate whether TyG-BMI was accurate detecting the general Japanese population....
Background The connection between the triglyceride-glucose index (TyG index) and gestational diabetes mellitus (GDM) is currently debated. Our study aimed to investigate TyG GDM within Korean population. Methods Using publically accessible data in Korea, we performed a secondary on sample of 589 pregnant women who were carrying single fetus. analysis employed binary logistic regression model, some sensitivity analyses, subgroup association occurrence GDM. To assess index’s potential predict...
Oxidative stress and neuroinflammation are two major causes leading to early brain injury after subarachnoid hemorrhage (SAH). Nuclear factor E2-related 2 (Nrf2) is a critical transcription that contributes antioxidant responses. Additionally, Nrf2 could inhibit transforming growth beta-activated kinase 1 (TAK1), which plays vital role in microglial activation-mediated neuroinflammation. Neferine (NE) exhibits considerable protective effects diverse disease models. However, the detailed...
Abstract Objective The connection between triglycerides to high-density lipoprotein cholesterol (TG/HDL-C) ratio and stroke risk is controversial. Our goal was explore this relationship in individuals aged 45 older enrolled the China Health Retirement Longitudinal Study (CHARLS). Methods analysis encompassed 10,164 participants from CHARLS cohorts. We applied Cox proportional-hazards regression model evaluate potential correlation TG/HDL-C incidence. Using a cubic spline function smooth...
Acute kidney injury (AKI) is a clinical syndrome associated with multitude of conditions. Although renal replacement therapy (RRT) remains the cornerstone treatment for advanced AKI, its implementation can potentially pose risks and may not be readily accessible across all healthcare settings regions. Elevated lactate levels are implicated in sepsis-induced AKI; however, it unclear whether increased directly induces AKI or elucidates underlying mechanisms. For human, measurement arterial...
While the connection between Triglyceride glucose-waist circumference (TyG-WC) index and risk of diabetes remains understudied, this particular research delves into potential predictive value TyG-WC within a significant Japanese population. This retrospective cohort study encompassed comprehensive analysis 15,413 adults, all whom were diabetes-free at outset period from 2004 to 2015. Comprehensive medical records obtained for participants who underwent physical examinations. The employed Cox...
The hepatic steatosis index (HSI) has been demonstrated to have a significant correlation with prediabetes and diabetes; however, its potential association reversion normal glucose regulation (NGR) from remains insufficiently investigated. primary objective of this study was elucidate the relationship between HSI levels probability NGR among Chinese adults prediabetes. This retrospective cohort utilized health examination data 11,241 Cox proportional hazard models were employed calculate...
Abstract Background and Aims Remote ischaemic pre-conditioning (RIPC) delivered shortly prior to an angiographic procedure may reduce contrast-associated acute kidney injury (CA-AKI). Whether a longer interval between RIPC contrast administration also reduces CA-AKI post-procedural complications after coronary angiography (CAG) or percutaneous intervention (PCI) is unknown. Methods This was multicentre, randomized trial of patients at risk undergoing elective CAG PCI comparing delayed (four...
Stem cell therapy, as a core treatment method in the field of regenerative medicine, has attracted much attention recent years due to its unique self-renewal and differentiation abilities. This article systematically reviews basic theory stem including definition, classification, principle mechanism, preparation quality control cells. In terms clinical application, therapy demonstrated extensive therapeutic potential: tissue repair, can effectively promote regeneration repair various tissues...
It has been demonstrated that neuronal nitric oxide synthase (nNOS) negatively regulates adult neurogenesis. However, the cellular and molecular mechanisms underlying are poorly understood. Here, we show nNOS from neural stem cells (NSCs) neurons play opposite role in regulating The NSCs treated with inhibitor N(5)-(1-imino-3-butenyl)-L- ornithine (L-VNIO) or gene deletion exhibited significantly decreased proliferation differentiation, indicating NSCs-derived is essential for cocultured...
Abstract Background Systemic inflammation is involved in the development of acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB). Ulinastatin, a urinary trypsin inhibitor (UTI), possesses variety anti-inflammatory effects. Therefore, we hypothesized that administration ulinastatin would reduce occurrence AKI patients undergoing CPB. Methods A retrospective propensity score matched analysis was used to evaluate effect on first documented CPB between January 2008...
<b><i>Introduction:</i></b> As disorder of tryptophan metabolism is common in CKD, the rate-limiting enzyme tryptophan, indoleamine-2,3-dioxygenase (IDO), has been reported to be involved while accurate mechanism remains unknown. This study was designed explore correlations between IDO and kidney fibrosis after ischemia-reperfusion injury (IRI). <b><i>Methods:</i></b> Wild-type (WT) mice knockout (IDO<sup>−/−</sup>) were divided...
Previous evidence revealed that central obesity played a vital role in the development of diabetes mellitus (DM). However, because imbalanced confounding variables, some studies have not wholly established association between and diabetes. Propensity score matching (PSM) analysis can minimize impact potential variables. Therefore, aim present study was to explore relationship Japanese population by using PSM analysis. This retrospective cohort included 15,453 adults who were free at baseline...
The transcription factor NF-κB has been found critical to the pathogenesis of renal ischemia-reperfusion injury, which is a major cause acute kidney injury (AKI). Activation dependent upon activation specific inhibitory κB kinase (IKK) subunit IKKβ. Here, we investigate whether small interfering RNA (siRNA) targeting IKKβ protects rats from ischemia- reperfusion in vivo. Renal was induced by clamping artery for 45 min. Rats were treated before ischemia with siRNA or scrambled siRNA,...
Background and objectives Impaired renal function in atherosclerotic renovascular disease (ARD) may be the result of crosstalk between stenosis amplified oxidative stress, inflammation fibrosis. Berberine (BBR) regulates cholesterol metabolism exerts antioxidant effects. Accordingly, we hypothesized that BBR treatment ameliorate ARD-induced kidney injury through its cholesterol-lowering effect also suppression pathways involved NFκB activation. Methods Male rats were subjected to unilateral...
Objective To evaluate the incidence, risk, or protective factors of acute kidney injury (AKI) in patients after cardiac surgery based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Methods A retrospective analysis 2,575 undergoing their first documented with cardiopulmonary bypass (CPB) was conducted. Perioperative variables were collected and analyzed. Univariate multiple logistic regression models used for determining association between development AKI risk factors....
Abstract Klotho is a protein primarily expressed in renal tubular epithelial cells. Studies have suggested that an antiaging reduces fibrosis after acute kidney injury (AKI) and inhibits stem cell senescence. Bone marrow mesenchymal cells (BMSCs) consistent proliferation ability multidirectional differentiation been used to treat tissue injury. Thus, we hypothesized BMSCs could increase the protective effects of BMSCs. To verify hypothesis, isolated from C57BL/6 mice, transfected them with...
Clear cell renal carcinoma (ccRCC), the most common histological subtype of kidney cancer, shows poor prognosis and non-sensitivity to radiotherapy or chemotherapy. The lncRNA small nucleolar RNA host gene 12 (SNHG12) has been revealed play a carcinogenic role in various neoplasms, but underlying mechanism ccRCC is still unclear. To explore potential SNHG12 ccRCC, data downloaded from Cancer Genome Atlas (TCGA) International Consortium (ICGC) Data Portal was used compare expression tumors...
Low levels of high-density lipoprotein cholesterol (HDL-C) and high alanine aminotransferase (ALT) are related to insulin resistance, metabolic syndrome, diabetes mellitus (DM). However, evidence on the connection between (ALT/HDL-C) ratio (DM) risk was limited. The study aimed investigate relationship baseline ALT/HDL-C DM among Japanese individuals.This second analysis based a cohort using open-source data. Data from 15,342 individuals who participated in medical examination program were...