A5004099714- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Pregnancy-related medical research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Nephrotoxicity and Medicinal Plants
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Inflammatory Biomarkers in Disease Prognosis
- Chronic Kidney Disease and Diabetes
- Cancer, Lipids, and Metabolism
- Cardiac and Coronary Surgery Techniques
- Central Venous Catheters and Hemodialysis
- Digestive system and related health
- Cardiac Arrest and Resuscitation
- Kruppel-like factors research
- Muscle and Compartmental Disorders
- Metabolism, Diabetes, and Cancer
- Gastrointestinal motility and disorders
- Electrohydrodynamics and Fluid Dynamics
- Plant Surface Properties and Treatments
- Estrogen and related hormone effects
- Renal and related cancers
- Aerosol Filtration and Electrostatic Precipitation
- Vascular Procedures and Complications
- Bone and Joint Diseases
Hangzhou First People's Hospital
2015-2024
Zhejiang University
2019-2024
South China Agricultural University
2024
Jackson Memorial Hospital
2019
Nanjing Medical University
2015-2017
Hangzhou Cancer Hospital
2017
State Key Laboratory of Kidney Diseases
2015
Chinese PLA General Hospital
2015
Abstract Background Ischemia–reperfusion injury (IRI)-induced acute kidney (AKI) can repair itself completely. However, most moderate and severe patients undergoing IRI-AKI progress to chronic disease due incomplete repair. The present study is aimed investigate the role of bone marrow mesenchymal stem cell-derived exosomes (MSC-Exo) with indoleamine 2,3-dioxygenase (IDO) overexpression on in mice after IRI. Methods IRI was established by clamping unilateral renal pedicles challenged...
Objective To evaluate the incidence, risk, or protective factors of acute kidney injury (AKI) in patients after cardiac surgery based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Methods A retrospective analysis 2,575 undergoing their first documented with cardiopulmonary bypass (CPB) was conducted. Perioperative variables were collected and analyzed. Univariate multiple logistic regression models used for determining association between development AKI risk factors....
Abstract Background Systemic inflammation is involved in the development of acute kidney injury (AKI) after cardiac surgery with cardiopulmonary bypass (CPB). Ulinastatin, a urinary trypsin inhibitor (UTI), possesses variety anti-inflammatory effects. Therefore, we hypothesized that administration ulinastatin would reduce occurrence AKI patients undergoing CPB. Methods A retrospective propensity score matched analysis was used to evaluate effect on first documented CPB between January 2008...
Increasing evidence suggests that macrophage polarization is involved in the recovery from ischemia/reperfusion (I/R)-induced acute kidney injury (AKI), implying regulation of homeostasis might mediate AKI recovery. Trib1 a key regulator differentiation, but its role remains unclear. Here, we aimed to investigate and link with phenotype process adaptive I/R-induced renal injury. Lentiviral vector-mediated RNA interference (RNAi) was used knock down expression mice, mouse model moderate...
During continuous spraying operations, the liquid in pesticide tank gradually decreases, and flight speed changes as route is altered. To maintain stable flight, rotor of a multi-rotor unmanned aerial system (UASS) constantly adjusts. explore variation law UASS under objective operation attributes, based on indoor outdoor experimental data, this paper constructs mathematical model relationship between thrust. The fitting parameter (R2) equal to 0.9996. Through neural network, prediction...
Ischemia/reperfusion injury (I/R) is the main causes of acute kidney (AKI), which a global health concern. Evidence suggests that asiaticoside plays vital roles on anti-inflammatory and, anti-kidney fibrosis effects, and promotes tissue repair. However, effects AKI caused by ischemia-reperfusion have not been well defined. Herein, we explored protective effect renal (IRI) using in vivo vitro studies, elucidated potential mechanism asiaticoside-mediated Results showed attenuated levels blood...
Aristolochic acid nephropathy (AAN) is a chronic, progressive interstitial nephritis. To date, treatment strategies remain limited. Mounting evidence shows that relaxin (RLX) possesses powerful anti-fibrotic and anti-apoptotic characteristics, therefore, the present study aimed to investigate possible protective role of RLX in aristolochic (AA) induced nephrotoxicity.The vitro cell tests were performed: embryonic kidney cells 293 treated with AA-I (40 μg/mL) or plus (100 ng/mL) groups then...
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). DN characterized by glomerular extracellular matrix accumulation, mesangial expansion, basement membrane thickening, and interstitial fibrosis. To date, mounting evidence has shown that H2 relaxin possesses powerful antifibrosis properties; however, mechanisms on diabetic remain unknown. Here, we aimed to explore whether can reduce production (ECM) secreted human cells (HMC). HMC were exposed 5.5 mM glucose...
This study aims to investigate basic clinical features of peritoneal dialysis (PD) patients, their prognostic risk factors, and establish a model for predicting one-year mortality.A national multi-center cohort was performed.A total 5,405 new PD cases from China Peritoneal Dialysis Registry in 2012 were enrolled group.All these patients had complete baseline data followed one year.Demographic collected.Cox proportional hazards regression used analyze factors model.A validation group...
Background. Contrast-induced acute kidney injury (CI-AKI) is one of the main causes iatrogenic (AKI); however, therapeutic strategies for AKI remain limited. This study aims to explore effect relaxin (RLX) on contrast-induced HK-2 apoptosis and its underlying mechanisms. Methods. Renal tubular epithelial cells (HK-2) were incubated either with or without ioversol, human H2 relaxin, LY294002 (the inhibitor PI3K/Akt signal pathway). Cell viability was evaluated a CCK-8 assay. Apoptotic...
Ischemia/reperfusion injury (I/R) is the major cause of acute kidney injury, which becomes a global health problem. The effects asiaticoside, as an anti-inflammatory drug, on renal ischemia-reperfusion have not been well defined.After CD4+ cells were treated with CD4+CD25+FOXP3+ Treg cell differentiation was detected by flow cytometry. viability and release inflammatory factors CCK-8 ELISA. Renal I/R mice model established, pre-treated asiaticoside or CD25 antibody infused cells....
TGF-β 1 has been recognized as a key mediator in DN. This study aimed to observe the effects of low-protein diets supplemented with ketoacid on mRNA and protein expression TβRI t TβRII receptors renal tissue diabetic rats. A diabetes model was established 72 male SD They were then equally randomized three groups: NPD group, LPD + KA group. Additional 24 rats receiving normal used control. Eight from each group sacrificed at weeks 4, 8, 12 after treatment, which SCr, BUN, serum albumin, h...
Though the albumin-to-alkaline phosphatase ratio (AAPR) is used as a biomarker in various diseases, little known about its effect on outcomes after peritoneal dialysis (PD).
Objective. To investigate the initial hemodialysis vascular access in Hangzhou and provide evidence for improving use of autologous arteriovenous fistula by identifying factors associated with choice access. Methods. We retrospectively studied 257 patients five units China during a 21-month period (January 2018 to September 2019). A logistic regression was used identify risk failing an at initiation hemodialysis. Results. (1) participants mean age <math...
Objective To explore the effect and mechanism of relaxin on production extracellular matrix (ECM) excreted by high glucose stimulated human renal mesangial cells. Methods Cultured cells (HMCs) were divided into three groups: ⑴ normal group (NG, 5.5 mmol/L D-glucose), ⑵ (HG, 30 ⑶ glucose+ group. Cell count kit (CCK8) was used to examine cell proliferation. The levels fibronectin collagen type Ⅳ in culture supernatants examined with a solid-phase enzyme-linked immunoadsorbent assay...
Abstract background Fibrinogen to pre‐albumin ratio (FPR) is a promising predictor of mortality in various cancers. The aim this study was explore the prognostic value FPR predict peritoneal dialysis (PD) patients. Methods We retrospectively analyzed 324 incident PD patients form January 2011 December 2020. Patients were stratified based on optimal thresholds for at baseline overall and cardiovascular during follow‐up. association all‐cause evaluated by Kaplan–Meier curve Cox regression...
negative group.The expression of miR-19b, miR-25, miR-93 and miR-15b in SLE active patients was significantly lower than that stable (P<0.05).The AUC evaluation for disease activity 0.856 (0.721, 0.992).The specificity sensitivity were 0.769 0.867, respectively.The levels miR-223 miR-20a decreased (P = 0.019; P 0.023), the miR-16 with non-primary P=0.045).CONCLUSIONS: Our study showed 4 B-cell-related miRNAs (miR-19b, miR-15b) differentially expressed plasma or phase, this may be important...