Li Zhu

ORCID: 0000-0001-5249-6536
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About
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Research Areas
  • ZnO doping and properties
  • Statistical Methods and Inference
  • Nuclear physics research studies
  • Crystallization and Solubility Studies
  • Gas Sensing Nanomaterials and Sensors
  • X-ray Diffraction in Crystallography
  • Genetic Mapping and Diversity in Plants and Animals
  • Advanced Photocatalysis Techniques
  • Toxic Organic Pollutants Impact
  • Copper-based nanomaterials and applications
  • Ga2O3 and related materials
  • Advanced Statistical Methods and Models
  • Membrane Separation Technologies
  • Quantum Chromodynamics and Particle Interactions
  • Cancer-related molecular mechanisms research
  • Corrosion Behavior and Inhibition
  • Advanced machining processes and optimization
  • Advanced Sensor and Energy Harvesting Materials
  • Heavy metals in environment
  • Atomic and Molecular Physics
  • Conducting polymers and applications
  • Surface Modification and Superhydrophobicity
  • Plant Stress Responses and Tolerance
  • Analytical chemistry methods development
  • Statistical Methods and Bayesian Inference

Wuhan Institute of Technology
2009-2025

Zhejiang University
2016-2025

Beihang University
2016-2025

Shandong University
2011-2025

Chinese Academy of Sciences
2016-2025

Shanghai Jiao Tong University
2016-2025

Nanjing Medical University
2015-2025

Jiangxi Provincial Children's Hospital
2025

Nantong University
2016-2025

Beijing Normal University
2016-2025

We have produced a draft sequence of the rice genome for most widely cultivated subspecies in China, Oryza sativa L. ssp. indica , by whole-genome shotgun sequencing. The was 466 megabases size, with an estimated 46,022 to 55,615 genes. Functional coverage assembled sequences 92.0%. About 42.2% exact 20-nucleotide oligomer repeats, and transposons were intergenic regions between Although 80.6% predicted Arabidopsis thaliana genes had homolog rice, only 49.4% A. . large proportion no...

10.1126/science.1068037 article EN Science 2002-04-05

Preclinical studies suggest that Reed-Sternberg cells exploit the programmed death 1 (PD-1) pathway to evade immune detection. In classic Hodgkin's lymphoma, alterations in chromosome 9p24.1 increase abundance of PD-1 ligands, PD-L1 and PD-L2, promote their induction through Janus kinase (JAK)-signal transducer activator transcription (STAT) signaling. We hypothesized nivolumab, a PD-1-blocking antibody, could inhibit tumor evasion patients with relapsed or refractory lymphoma.In this...

10.1056/nejmoa1411087 article EN New England Journal of Medicine 2014-12-06

The combined adsorption and partition effects of biochars with varying fractions noncarbonized organic matter have not been clearly defined. Biochars, produced by pyrolysis pine needles at different temperatures (100−700 °C, referred as P100−P700), were characterized elemental analysis, BET-N2 surface areas FTIR. Sorption isotherms naphthalene, nitrobenzene, m-dinitrobenzene from water to the compared. parameters (N logKf) are linearly related sorbent aromaticities, which increase pyrolytic...

10.1021/es8002684 article EN Environmental Science & Technology 2008-06-11

To evaluate the efficacy and safety profile of S-1 combined with oxaliplatin (SOX) against unresectable advanced or metastatic gastric cancer.Oxaliplatin was administered intravenously at 100mg/m2 for two hours on day 1 b.i.d. 80mg/m2/day days 1-14 followed by a 7-day rest during 3-week schedule.All 51 patients were assessed adverse events. The response disease control rates 41% 90%, respectively. rate significantly improved in ECOG performance status no more than 1, elevated CEA levels...

10.5754/hge11893 article EN Hepatogastroenterology 2012-02-13

Cancer cells can exploit the programmed death-1 (PD-1) immune checkpoint pathway to avoid surveillance by modulating T-lymphocyte activity. In part, this may occur through overexpression of PD-1 and ligands (PD-L1 PD-L2) in tumor microenvironment. blockade has produced significant antitumor activity solid tumors, similar evidence emerged hematologic malignancies.In phase I, open-label, dose-escalation, cohort-expansion study, patients with relapsed or refractory B-cell lymphoma, T-cell...

10.1200/jco.2015.65.9789 article EN Journal of Clinical Oncology 2016-06-07

Summary Searching for an effective dimension reduction space is important problem in regression, especially high dimensional data. We propose adaptive approach based on semiparametric models, which we call the (conditional) minimum average variance estimation (MAVE) method, within quite a general setting. The MAVE method has following advantages. Most existing methods must undersmooth nonparametric link function estimator to achieve faster rate of consistency parameters (than that function)....

10.1111/1467-9868.03411 article EN Journal of the Royal Statistical Society Series B (Statistical Methodology) 2002-08-01

A hybridized self-powered textile for simultaneously collecting solar energy and random body motion was demonstrated.

10.1126/sciadv.1600097 article EN cc-by-nc Science Advances 2016-10-07

Water chemistry can be a major factor regulating the toxicity mechanism of ZnO nanoparticles (nano-ZnO) in water. The effect five commonly used aqueous media with various chemical properties on nano-ZnO to Escherichia coli O111 (E. coli) was investigated, including ultrapure water, 0.85% NaCl, phosphate-buffered saline (PBS), minimal Davis (MD), and Luria-Bertani (LB). Combined results physicochemical characterization antibacterial tests suggest that is mainly due free zinc ions labile...

10.1021/es102624t article EN Environmental Science & Technology 2011-01-31

Carbon nanomaterials are novel manufactured materials, having widespread potential applications. Adsorption of hydrophobic organic compounds (HOCs) by carbon may enhance their toxicity and affect the fate, transformation, transport HOCs in environment. In this research, adsorption naphthalene, phenanthrene, pyrene onto six nanomaterials, including fullerenes, single-walled nanotubes , multiwalled was investigated, which is first systematic study on polycyclic aromatic hydrocarbons (PAHs)...

10.1021/es052208w article EN Environmental Science & Technology 2006-02-16

A novel hydrogel with a new, well- defined network structure is prepared through two-step method in which the radiation-peroxidized macromolecular microspheres act as both initiators and crosslinkers. The microsphere composite (see figure) can effectively dissipate applied mechanical stress has extremely high strength. Some of hydrogels nearly completely recover their original shapes, even after an strain (99.7%) compression tests. Supporting information for this article available on WWW...

10.1002/adma.200602533 article EN Advanced Materials 2007-05-15

This study aims to explore the fundamental surface characteristics of polydopamine (pDA)-coated hydrophobic polymer films. A poly(vinylidene fluoride) (PVDF) film was modified by dip coating in an aqueous solution dopamine on basis its self-polymerization and strong adhesion feature. The deposition rates surfaces increased with increasing temperature as evaluated both spectroscopic ellipsometry scanning electronic microscopy (SEM). Changes morphologies pDA-coated films well size shape pDA...

10.1021/la202877k article EN Langmuir 2011-10-20

Abstract In this study, we investigated lipopolysaccharide (LPS)-induced cognitive impairment and neuroinflammation in C57BL/6J mice by using behavioral tests, immunofluorescence, enzyme-linked immunosorbent assay (ELISA) Western blot. We found that LPS treatment leads to sickness behavior as shown the Morris water maze passive avoidance test, these effects were accompanied microglia activation (labeled ionized calcium binding adaptor molecule-1, IBA-1) neuronal cell loss...

10.1038/s41598-019-42286-8 article EN cc-by Scientific Reports 2019-04-08

This article is concerned with screening features in ultrahigh-dimensional data analysis, which has become increasingly important diverse scientific fields. We develop a sure independence procedure based on the distance correlation (DC-SIS). The DC-SIS can be implemented as easily (SIS) Pearson proposed by Fan and Lv. However, significantly improve SIS. Lv established property for SIS linear models, but valid under more general settings, including models. Furthermore, implementation of does...

10.1080/01621459.2012.695654 article EN Journal of the American Statistical Association 2012-06-01

Nitrogen modified reduced graphene oxide (N-RGO) was prepared by a hydrothermal method. The nitrogen modification enhanced its adsorption and catalysis ability. For an initial bisphenol concentration of 0.385 mmol L–1, the capacity N-RGO evaluated as 1.56 1.43 g–1 for A (BPA) F (BPF), respectively, both which were about 1.75 times that (0.90 0.84 g–1) on N-free RGO. could activate persulfate, producing strong oxidizing sulfate radicals. apparent degradation rate constant BPA 0.71 min–1,...

10.1021/acs.est.5b01059 article EN Environmental Science & Technology 2015-05-06

Tree diversity improves forest productivity Experimental studies in grasslands have shown that the loss of species has negative consequences for ecosystem functioning. Is same true forests? Huang et al. report first results from a large biodiversity experiment subtropical China. The study combines many replicates, realistic tree densities, and plot sizes with wide range richness levels. After 8 years experiment, findings suggest strong positive effects on carbon accumulation. Thus, changing...

10.1126/science.aat6405 article EN Science 2018-10-04

Piezo-actuated stages have become more and promising in nanopositioning applications due to the excellent advantages of fast response time, large mechanical force, extremely fine resolution. Modeling control are critical achieve objectives for high-precision motion. However, piezo-actuated themselves suffer from inherent drawbacks produced by creep hysteresis nonlinearities vibration caused lightly damped resonant dynamics, which make modeling such systems challenging. To address these...

10.1109/tase.2014.2352364 article EN IEEE Transactions on Automation Science and Engineering 2014-09-24

Summary Rice blast, caused by the fungal pathogen Magnaporthe grisea , is one of most devastating diseases in rice worldwide. The dominant resistance gene, Pi‐d2 [previously named Pi‐d(t)2 ], present variety Digu, confers gene‐for‐gene to Chinese blast strain, ZB15. was previously mapped close centromere chromosome 6. In this study, gene isolated a map‐based cloning strategy. encodes receptor‐like kinase protein with predicted extracellular domain bulb‐type mannose specific binding lectin...

10.1111/j.1365-313x.2006.02739.x article EN The Plant Journal 2006-05-04

The insulin signaling pathway is activated by tyrosine phosphorylation of the receptor and key post-receptor substrate proteins balanced action specific protein-tyrosine phosphatases (PTPases). PTPase activity, in turn, highly regulated vivo oxidation/reduction reactions involving cysteine thiol moiety required for catalysis. Here we show that stimulation generates a burst intracellular H2O2 insulin-sensitive hepatoma adipose cells associated with reversible oxidative inhibition up to 62%...

10.1074/jbc.c100109200 article EN cc-by Journal of Biological Chemistry 2001-06-01

A double-hyperfragment event has been found in a hybrid-emulsion experiment. It is identified uniquely as the sequential decay of ( 6)(LambdaLambda)He emitted from Xi(-) hyperon nuclear capture at rest. The mass and Lambda-Lambda interaction energy DeltaB(LambdaLambda) have measured for first time devoid ambiguities due to possibilities excited states. value 1.01+/-0.20(+0.18)(-0.11) MeV. This demonstrates that weakly attractive.

10.1103/physrevlett.87.212502 article EN Physical Review Letters 2001-11-02
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