Antonio Amoroso
A5034479226- Renal Diseases and Glomerulopathies
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Celiac Disease Research and Management
- Kidney Stones and Urolithiasis Treatments
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Biomedical Research and Pathophysiology
- Genetic and Kidney Cyst Diseases
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Complement system in diseases
- Porphyrin Metabolism and Disorders
- Hematopoietic Stem Cell Transplantation
- Transplantation: Methods and Outcomes
- Chronic Kidney Disease and Diabetes
- Renal and related cancers
University of Naples Federico II
2014-2025
Leibniz Institute for Solid State and Materials Research
2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2015-2024
University of Turin
2015-2024
Ospedale Regina Margherita
2024
Areté Associates (United States)
2023
Regione Piemonte
2022
University of Milan
1984-2021
Ospedale San Paolo
2021
Agenzia Regionale per la Protezione dell'ambiente ligure
2019-2021
We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects established a reference map the architecture MS that includes 200 autosomal susceptibility variants outside major histocompatibility complex (MHC), one chromosome X variant, 32 within extended MHC. used an ensemble methods to prioritize 551 putative genes implicate innate adaptive pathways distributed across cellular components immune system. Using expression profiles from purified human microglia, we...
BackgroundChildren with cow's milk allergy (CMA) have an increased risk of other allergic manifestations (AMs).ObjectiveWe performed a parallel-arm randomized controlled trial to test whether administration extensively hydrolyzed casein formula (EHCF) containing the probiotic Lactobacillus rhamnosus GG (LGG) can reduce occurrence AMs in children CMA.MethodsChildren IgE-mediated CMA were randomly allocated EHCF or EHCF+LGG groups and followed for 36 months. The main outcome was at least 1 AM...
This study was designed to identify the target molecules of natural killer (NK) cell-mediated recognition normal allogeneic cells. As previously shown, gene(s) governing first NK-defined allospecificity (specificity 1) were found be localized in major histocompatibility complex region between BF gene and HLA-A. In addition, analysis a described family revealed that donor (donor 81) heterozygous for three distinct allospecificities (specificities 1, 2, 5). HLA variants derived from...
The disease complex medullary cystic disease/familial juvenile hyperuricemic nephropathy (MCKD/FJHN) is characterized by alteration of urinary concentrating ability, frequent hyperuricemia, tubulo-interstitial fibrosis, cysts at the cortico-medullary junction and renal failure. MCKD/FJHN caused mutations gene encoding uromodulin, most abundant protein in urine. Here, we describe new missense three families with demonstrate allelism a glomerulocystic kidney (GCKD) variant, showing association...
DNA methylation of the Th1 and Th2 cytokine genes is altered during cow's milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) essential for development function regulatory T cells (Tregs) involved in oral tolerance acquisition. We assessed whether acquisition children with IgE-mediated CMA associated demethylation Treg-specific demethylated region (TSDR) FoxP3. Forty (aged 3–18 months) were enrolled: 10 active (group 1), who outgrew after dietary treatment an extensively...
Food allergy (FA) is a growing health problem worldwide. Effective strategies are advocated to limit the disease burden. Human milk (HM) could be considered as protective factor against FA, but its mechanisms remain unclear. Butyrate gut microbiota-derived metabolite able exert several immunomodulatory functions. We aimed define butyrate concentration in HM, and see whether detected HM modulate of immune tolerance.HM from 109 healthy women was assessed by GS-MS. The effect on tolerogenic...
Abstract: We assembled and analyzed genetic data of 47,351 multiple sclerosis (MS) subjects 68,284 control establish a reference map the architecture MS that includes 200 autosomal susceptibility variants outside major histocompatibility complex (MHC), one chromosome X variant, 32 independent associations within extended MHC. used an ensemble methods to prioritize up 551 potentially associated genes, implicate innate adaptive pathways distributed across cellular components immune system....
SARS-CoV-2 infection is heterogeneous in clinical presentation and disease evolution. To investigate whether immune response to the virus can be influenced by genetic factors, we compared HLA AB0 frequencies organ transplant recipients waitlisted patients according presence or absence of infection.A retrospective analysis was performed on an Italian cohort composed transplanted a January 2002 March 2020 time frame. Data from this were merged with registry COVID+ subjects, evaluating status...
In the context of kidney transplantation, genomic incompatibilities between donor and recipient may lead to allosensitization against new antigens. We hypothesized that recessive inheritance gene-disrupting variants represent a risk factor for allograft rejection.We performed two-stage genetic association study rejection. first stage, we screen 50 common gene-intersecting deletion polymorphisms in cohort transplant recipients. second replicated our findings three independent cohorts...
Since February 21 2020, when the Italian National Institute of Health (Istituto Superiore di Sanità-ISS) reported first autochthonous case infection, a dedicated surveillance system for SARS-CoV-2-positive (COVID+) cases has been created in Italy. These data were cross-referenced with those inside Information Transplant System order to assess cumulative incidence (CI) and outcome SARS-COV-2 infection solid organ transplant recipients (SOTRs) who are assumed be most at risk. We compared our...
African Americans have a significantly higher risk of developing chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play major role this disparity. While 13% carry high-risk recessive genotypes, only fraction these individuals develops FSGS or failure, indicating involvement additional disease modifiers. Here, we show that presence p.N264K missense variant, when co-inherited with G2 allele,...