A5072186802- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Transplantation: Methods and Outcomes
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- COVID-19 Impact on Reproduction
- Alcohol Consumption and Health Effects
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Parkinson's Disease and Spinal Disorders
- Tuberous Sclerosis Complex Research
- Healthcare Systems and Challenges
- Organ and Tissue Transplantation Research
- Thermodynamic properties of mixtures
- Recycling and Waste Management Techniques
- Healthcare and Environmental Waste Management
Istituto Superiore di Sanità
2017-2025
Sapienza University of Rome
2009-2024
Regione del Veneto
2023
Gruppo Italiano per il Trapianto di Midollo Osseo
2020
Ospedale Regina Margherita
2010
The spread of Coronavirus Disease 2019 (COVID-19) has already reached a pandemic dimension within few weeks. Italy been one the first countries dealing with outbreak COVID-19, and severe measures have adopted to limit viral transmission. COVID-19 may several implications in organ transplant activity that physicians should be aware of. initial experience gained during shows around 10% infected patients need intensive care management overcome acute respiratory distress syndrome. Due...
SARS-CoV-2 infection is heterogeneous in clinical presentation and disease evolution. To investigate whether immune response to the virus can be influenced by genetic factors, we compared HLA AB0 frequencies organ transplant recipients waitlisted patients according presence or absence of infection.A retrospective analysis was performed on an Italian cohort composed transplanted a January 2002 March 2020 time frame. Data from this were merged with registry COVID+ subjects, evaluating status...
Since February 21 2020, when the Italian National Institute of Health (Istituto Superiore di Sanità-ISS) reported first autochthonous case infection, a dedicated surveillance system for SARS-CoV-2-positive (COVID+) cases has been created in Italy. These data were cross-referenced with those inside Information Transplant System order to assess cumulative incidence (CI) and outcome SARS-COV-2 infection solid organ transplant recipients (SOTRs) who are assumed be most at risk. We compared our...
COVID-19 pandemic dramatically impacted transplantation landscape. Scientific societies recommend against the use of donors with active SARS-CoV-2 infection. Italian Transplant Authority recommended to test recipients/donors for SARS-CoV-2-RNA immediately before liver transplant (LT) and, starting from November 2020, grafts deceased infection were allowed be considered urgent-need candidates active/resolved COVID-19. We present results first 10 LTs within an multicenter series. Only two...
To implement split liver transplantation (SLT) a mandatory-split policy has been adopted in Italy since August 2015: donors aged 18-50 years at standard risk are offered for SLT, resulting left-lateral segment (LLS) graft children and an extended-right (ERG) adults. We aim to analyze the impact of new on (LT)-waiting list SLT outcomes, compared old allocation policy. Between 2015 December 2016 out 413 potentially "splittable" donors, 252 (61%) were proposed whom 53 (21%) accepted whereas 101...
Total hepatectomy and liver transplantation has emerged as a game-changing strategy in the treatment of several liver-confined primary or metastatic tumors, opening new era transplant oncology. However, expansion indications is going to worsen chronic scarcity organs, strategies are needed enlarge donor pool. A possible source organs could be developing split (SLT) programs. We propose refer donors aged 18-50 years unsuitable for pediatric patients 50-60 evaluation. This will generate small...
Patients with HDV/HBV-related end-stage liver disease candidates for transplantation(LT) have traditionally been regarded as a special population, although their outcomes are controversial. A intention-to-treat(ITT) analysis of long-term HDV/HBV-coinfected patients waitlisted LT in Italy, between 2011-2020, was performed and compared to HBV-monoinfected candidates. Out 1,731 HBV-infected candidates, 1,237(71.5%) had HBV-monoinfection 494(28.5%) HDV/HBV-coinfection. At listing, were...
BackgroundInternational consensus has recently introduced a new definition of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). We sought to analyse epidemiological trends, prognostic features, and transplant survival benefits MASLD non-MASLD patients waiting for liver transplantation (LT) in Italy.Materials methodsUtilising the Italian Transplant Registry database, we analysed data from adult listed primary LT due end-stage chronic disease between January 2012 December 2022....
The COVID-19 pandemic caused temporary drops in the supply of organs for transplantation, leading to renewed debate about whether T2 hepatocellular carcinoma (HCC) patients should receive priority during these times. aim this study was provide a quantitative model aid decision-making liver transplantation HCC. We proposed novel ethical framework where individual transplant benefit HCC patient outweigh harm others on waiting list, determining “net benefit”, define appropriate organ...
Very scanty evidence is available on factors influencing the choice of immunosuppressive drug therapy after kidney transplantation.
The study of immune response to SARSCoV-2 infection in different solid organ transplant settings represents an opportunity for clarifying the interplay between SARS-CoV-2 and system. In our nationwide registry from Italy, we specifically evaluated, during first wave pandemic, i.e., non-vaccinated patients, COVID-19 prevalence infection, mortality, lethality liver recipients (LTRs), using non-liver (NL-SOTRs) Italian general population (GP) as comparators.