A5053816364- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Dialysis and Renal Disease Management
- Palliative Care and End-of-Life Issues
- COVID-19 Impact on Reproduction
- Renal and Vascular Pathologies
- Viral Infections and Immunology Research
- Biomedical Ethics and Regulation
- Healthcare Systems and Challenges
- Empathy and Medical Education
- Pain Management and Placebo Effect
- Liver Disease Diagnosis and Treatment
- Patient Dignity and Privacy
- Drug-Induced Hepatotoxicity and Protection
- Historical and Environmental Studies
- Art Therapy and Mental Health
- Enterobacteriaceae and Cronobacter Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Diabetes and associated disorders
Istituto Superiore di Sanità
2010-2023
Ospedale regionale di Lugano
2020
Medical University of Vienna
2020
Health City Institute
2019
Istituto Nazionale di Fisica Nucleare, Centro Nazionale Analisi Fotogrammi
2019
Radboud University Nijmegen
2011
SARS-CoV-2 infection is heterogeneous in clinical presentation and disease evolution. To investigate whether immune response to the virus can be influenced by genetic factors, we compared HLA AB0 frequencies organ transplant recipients waitlisted patients according presence or absence of infection.A retrospective analysis was performed on an Italian cohort composed transplanted a January 2002 March 2020 time frame. Data from this were merged with registry COVID+ subjects, evaluating status...
Organ transplantation, e.g., of the heart, liver, or kidney, is nowadays a routine strategy to counteract several lethal human pathologies. From literature data and from obtained in Italy, striking scenario appears well evident: women are more often donors than recipients. On other hand, recipients organs mainly males, probably reflecting gender bias incidence transplant-related The impact sex mismatch on transplant outcome remains debated, even though donor-recipient mismatch, due...
Since February 21 2020, when the Italian National Institute of Health (Istituto Superiore di Sanità-ISS) reported first autochthonous case infection, a dedicated surveillance system for SARS-CoV-2-positive (COVID+) cases has been created in Italy. These data were cross-referenced with those inside Information Transplant System order to assess cumulative incidence (CI) and outcome SARS-COV-2 infection solid organ transplant recipients (SOTRs) who are assumed be most at risk. We compared our...
To implement split liver transplantation (SLT) a mandatory-split policy has been adopted in Italy since August 2015: donors aged 18-50 years at standard risk are offered for SLT, resulting left-lateral segment (LLS) graft children and an extended-right (ERG) adults. We aim to analyze the impact of new on (LT)-waiting list SLT outcomes, compared old allocation policy. Between 2015 December 2016 out 413 potentially "splittable" donors, 252 (61%) were proposed whom 53 (21%) accepted whereas 101...
In this study, we assessed the mid-term outcomes of patients who received a heart donation from marginal donor (MD), and compared them with those an organ standard (SD).All underwent HTx between January 2012 December 2020 were enrolled at single institution. The primary endpoints early long-term survival MD recipients. Risk factors for graft failure (PGF) mortality in recipients also analyzed. secondary endpoint was comparison versus SD recipients.In total, 238 HTx, 64 (26.9%) whom MD....
The goal of post-transplant immunosuppressive drug therapy is to prevent organ rejection while minimizing toxicities. In clinical practice, a multidrug approach commonly used and involves drugs with different mechanisms action, including calcineurin inhibitors (CNI) (tacrolimus or cyclosporine), antimetabolite (antimet) (mycophenolate azathioprine), mechanistic target rapamycin (mTOR) (sirolimus everolimus), and/or steroids. Although evidence based on several randomized trials available, the...
Background The well-documented benefits of physical activity (PA) are still poorly characterized in long-term kidney transplant outcome. This study analyzed the impact over a 10-year follow-up PA on graft function Italian recipients (KTRs).Methods Since 2002, Transplant-Information-System collected donor and recipient baseline transplant-related parameters KTRs. In 2015, 'penchant for PA' (PA ≥ 30-min, 5 times/week) was added. Stable patients aged ≥18 years at time first-transplantation were...
Background In immunosuppression after transplantation, several multi-drug approaches are used, involving calcineurin inhibitors ( CNI: tacrolimus-TAC or cyclosporine-CsA ), antimetabolites antiMs mammalian target of rapamycin mTORis and corticosteroids. However, data on immunosuppressive therapy by organ its space–time variability lacking. Methods An Italian multicentre observational cohort study was conducted using health information systems. Patients with incident transplant during...
Multiple barriers diminish access to kidney transplantation (KT) in immigrant compared non-immigrant populations. It is unknown whether immigration status reduces the likelihood of KT after wait-listing despite universal healthcare coverage with uniform transplantation.We retrospectively collected data all adult waiting list (WL) registrants Italy (2010-20) followed for 5 years until death, a foreign center, deceased-donor transplant (DDKT), living-donor (LDKT) or permanent withdrawal from...
LETTER TO THE EDITOR Transpl Int, 07 September 2023 https://doi.org/10.3389/ti.2023.11674
Very scanty evidence is available on factors influencing the choice of immunosuppressive drug therapy after kidney transplantation.
Background. The risk of disease transmission from nonstandard donors (NSRDs) is low, and outcomes are similar or better relative to transplants performed with standard criteria donors. However, NSRDs have posed new ethical challenges the informed consent (IC) process. Based on shared decision-making model, coinciding 3 main timings IC process ([1] pretransplant assessments waiting list registration, [2] time list, [3] organ offer), we put forward a model (3-T Model) summarize knowledge for...
The study of immune response to SARSCoV-2 infection in different solid organ transplant settings represents an opportunity for clarifying the interplay between SARS-CoV-2 and system. In our nationwide registry from Italy, we specifically evaluated, during first wave pandemic, i.e., non-vaccinated patients, COVID-19 prevalence infection, mortality, lethality liver recipients (LTRs), using non-liver (NL-SOTRs) Italian general population (GP) as comparators.
The national protocol for the handling of high-urgency (HU) liver organ procurement transplant is administered by Italian National Transplant Center. In recent years, we have witnessed a change in requests to access program. We therefore evaluated their temporal trend, need criteria, percentage transplants performed, time request satisfaction, and follow-up.We analyzed all HU program received during 4-year period 2014 2017 adult recipients (≥18 years age): variables linked recipient or donor...