A5061276283- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Infection Control in Healthcare
- Surgical site infection prevention
- Urinary Tract Infections Management
- Emergency and Acute Care Studies
- Alzheimer's disease research and treatments
- Patient Satisfaction in Healthcare
- Mycobacterium research and diagnosis
- Geriatric Care and Nursing Homes
- Cardiac, Anesthesia and Surgical Outcomes
- Bacterial Identification and Susceptibility Testing
- Health Systems, Economic Evaluations, Quality of Life
- Sepsis Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Healthcare cost, quality, practices
- COVID-19 and healthcare impacts
- Clostridium difficile and Clostridium perfringens research
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and Mental Health
Regione Emilia-Romagna
2016-2025
Agenzia Sanitaria e Sociale Regionale
2016-2025
Pontificia Universidad Javeriana
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
1999-2024
Azienda Ospedaliera Sant'Andrea
2024
Vita-Salute San Raffaele University
2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2024
CTO Andrea Alesini
2024
Barcelona School of Economics
2023
Universitat de Barcelona
2023
Point prevalence surveys of healthcare-associated infections (HAI) and antimicrobial use in the European Union Economic Area (EU/EEA) from 2016 to 2017 included 310,755 patients 1,209 acute care hospitals (ACH) 28 countries 117,138 residents 2,221 long-term facilities (LTCF) 23 countries. After national validation, we estimated that 6.5% (cumulative 95% confidence interval (cCI): 5.4–7.8%) ACH 3.9% (95% cCI: 2.4–6.0%) LTCF had at least one HAI (country-weighted prevalence). On any given day,...
BackgroundHealth-care-associated infections are a major threat to patient safety worldwide. Transmission is mainly via the hands of health-care workers, but compliance with recommendations usually low and effective improvement strategies needed. We assessed effect WHO's strategy for hand hygiene in five countries.MethodsWe did quasi-experimental study between December, 2006, 2008, at six pilot sites (55 departments 43 hospitals) Costa Rica, Italy, Mali, Pakistan, Saudi Arabia. A step-wise...
Infections with carbapenem-resistant Enterobacteriaceae (CRE) are increasingly being reported from patients in healthcare settings. They associated high patient morbidity, attributable mortality and hospital costs. Patients who "at-risk" may be carriers of these multidrug-resistant (MDR-E). The purpose this guidance is to raise awareness identify the when admitted a setting outline effective infection prevention control measures halt entry spread CRE. was created by group experts were...
Antimicrobial agents used to treat infections are life-saving. Overuse may result in more frequent adverse effects and emergence of multidrug-resistant microorganisms. In 2016–17, we performed the second point-prevalence survey (PPS) healthcare-associated (HAIs) antimicrobial use European acute care hospitals. We included 1,209 hospitals 310,755 patients 28 31 Union/European Economic Area (EU/EEA) countries. The weighted prevalence EU/EEA was 30.5% (95% CI: 29.2–31.9%). most common...
To identify avoidable risk factors for central venous catheter (CVC) infections in patients undergoing short-term catheterization.Prospective multicenter cohort study.Two university teaching hospitals and five large nonteaching hospitals.Patients admitted to intensive care units or surgical exposed CVCs.Of 623 catheterization episodes, 9.3% were associated with catheter-related (CRI). The skin at the site was frequently colonized (16.2%) potential source of infection 56.1% cases, mostly...
The Chikungunya virus infection zones have now quickly spread from Africa to parts of Asia, North America and Europe. Originally thought trigger a disease only mild symptoms, recently caused large-scale fatalities widespread economic loss that was linked recent genetic mutation evolution. Due the paucity information on immunological progression, we investigated serum levels 13 cytokines/chemokines during acute phase 6- 12-month post-infection follow-up patients Italian outbreak. We found...
After an outbreak of Chikungunya infection in Emilia-Romagna Region (North-eastern Italy), a survey was performed to estimate the seroprevalence antibody virus and proportion asymptomatic infections, identify factors associated with infection, evaluate performance surveillance system. The method used on random sample residents village largest number reported cases. prevalence 10.2% (33 325), being higher older people males, lower when window screens insect repellents were used. Only 18%...
Antimicrobials are commonly prescribed and contribute to the development of antimicrobial resistance in long-term care facilities (LTCFs). In 2010, European Centre for Disease Prevention Control initiated point prevalence surveys (PPS) healthcare-associated infections use LTCFs, performed by external contractors as Healthcare-Associated Long-Term (HALT) projects. Here, we investigated characteristics stewardship indicators LTCFs 2016-17. Twenty-four Union/European Economic Area (EU/EEA)...
Surgical site infections (SSI) remain a major clinical problem in terms of morbidity, mortality, and hospital costs. Nearly 60% SSI diagnosis occur the postdischarge period. However, literature provides little information on risk factors associated to in-hospital occurrence. A national prospective multicenter study was conducted with aim assessing incidence both postdisharge SSI, factors. In 2002, one-month, surveillance General Gynecological units 48 Italian hospitals. Case ascertainment...
To investigate determinants of antibiotic prescription in paediatric care, as a first step multilevel intervention to improve prescribing for common respiratory tract infections (RTIs) northern Italian region with high rate. A two-step survey was performed: phase I, knowledge, and attitudes were explored involving all family hospital paediatricians Emilia-Romagna sample parents. In II, patient care practices stratified random visits, both hospitals physician's clinics; parent expectations...
ObjectivesThe aim of this study was to investigate antimicrobial prescribing in nursing homes countries across Europe.
Alzheimer's disease (AD) is the most common cause of dementia among older adults. Accumulation amyloid-β (Aβ) in brain considered central AD pathogenesis and its understanding crucial for developing new diagnostic therapeutic approaches. Recent literature suggests that ageing may induce post translational modifications Aβ, form spontaneous amino acid modifications, which enhance pathogenic properties, contributing to aggregation. In this study, we have investigated whether isoaspartate...
The spread of carbapenem-resistant Enterobacteriaceae (CRE) represents one the most worrisome problems for clinical medicine worldwide. In Italy, Antibiotic-Resistance-Istituto Superiore di Sanità surveillance network, in collaboration with Committee Antimicrobial Agents Italian Society Clinical Microbiologists, promoted a study to investigate carbapenem-resistance mechanisms, clonal relatedness and capsular typing recent collection Klebsiella pneumoniae (CR-KP). A total 17 laboratories...
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Following the rapid increase of infections due to carbapenemase-producing Enterobacteriaceae (CPE) in Italy, national surveillance bloodstream (BSI) CPE (Klebsiella pneumoniae and Escherichia coli) was instituted 2013. All CPE-BSI cases reported years 2014-17 were analysed order investigate incidence rate (IR), trend, main individual characteristics enzymes involved resistance. Throughout this period, 7,632 (IR: 3.14/100,000 inhabitants) from all 21 regions autonomous provinces with an...
Candida auris is an emerging fungus that represents a serious health threat globally. In Italy, the first case was detected in July 2019. Then, one reported to Ministry of Health (MoH) on January 2020. Nine months later, huge number cases were northern Italy. Overall, 361 17 healthcare facilities between 2019 and December 2022 Liguria, Piedmont, Emilia-Romagna, Veneto regions, including 146 (40.4%) deaths. The majority (91.8%) considered as colonised. Only had history travel abroad....