A5044010610- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Reproductive tract infections research
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Malaria Research and Control
- Antibiotic Resistance in Bacteria
- Syphilis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Urinary Tract Infections Management
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- SARS-CoV-2 detection and testing
- Mycobacterium research and diagnosis
- Oral microbiology and periodontitis research
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Zoonotic diseases and public health
- Insect and Pesticide Research
- Toxin Mechanisms and Immunotoxins
- Vector-Borne Animal Diseases
- Orthopedic Infections and Treatments
- Viral Infections and Outbreaks Research
- Pneumonia and Respiratory Infections
University of Bologna
2016-2025
Azienda Unità Sanitaria Locale Della Romagna
2016-2025
Azienda USL di Bologna
2003-2024
Azienda-Unita' Sanitaria Locale Di Cesena
2013-2022
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
Policlinico S.Orsola-Malpighi
2003-2020
Clinical Orthopaedics and Related Research
2018
Université Paris Cité
2015
Université d'Abomey-Calavi
2015
T cells are involved in the early identification and clearance of viral infections also support development antibodies by B cells. This central role for makes them a desirable target assessing immune response to SARS-CoV-2 infection. Here, we combined two high-throughput profiling methods create quantitative picture T-cell SARS-CoV-2. First, at individual level, deeply characterized 3 acutely infected 58 recovered COVID-19 subjects experimentally mapping their CD8 through antigen stimulation...
Abstract We describe the establishment and current content of ImmuneCODE™ database, which includes hundreds millions T-cell Receptor (TCR) sequences from over 1,400 subjects exposed to or infected with SARS-CoV-2 virus, as well 135,000 high-confidence SARS-CoV-2-specific TCRs. This database is made freely available, data contained in it can be downloaded analyzed online offline assist global efforts understand immune response virus develop new interventions.
We describe the establishment and current content of ImmuneCODE™ database, which includes hundreds millions T-cell Receptor (TCR) sequences from over 1,400 subjects exposed to or infected with SARS-CoV-2 virus, as well 160,000 high-confidence SARS-CoV-2-associated TCRs. This database is made freely available, data contained in it can be used assist global efforts understand immune response virus develop new interventions.
We report a case of Usutu virus (USUV)-related illness in patient that underwent an orthotropic liver transplant (OLT). Post transplant, the developed clinical signs possible neuroinvasive disease with significant loss cerebral functions. USUV was isolated Vero E6 cells from plasma sample obtained immediately before surgery, and RNA demonstrated by RT-PCR sequencing. This enlarges panel emerging mosquito-borne flavivirus-related humans.
Usutu virus (USUV) is a mosquito-borne flavivirus that emerged 2001 in Austria and caused deaths wild birds. In Germany, 70,378 female mosquitoes were captured 2009 2010 assayed for USUV. Virus was isolated cell culture from one pool of Culex pipiens trapped exclusively August Weinheim, Germany. Subsequent phylogenetic analysis demonstrated close relationship between the USUV strain Germany Austria, which detected dead blackbird 2004.
The Chikungunya virus infection zones have now quickly spread from Africa to parts of Asia, North America and Europe. Originally thought trigger a disease only mild symptoms, recently caused large-scale fatalities widespread economic loss that was linked recent genetic mutation evolution. Due the paucity information on immunological progression, we investigated serum levels 13 cytokines/chemokines during acute phase 6- 12-month post-infection follow-up patients Italian outbreak. We found...
Usutu virus (USUV) is an African mosquito-borne flavivirus, member of the Japanese encephalitis antigenic group. This avian transmitted by arthropod vectors (mainly mosquitoes Culex pipiens complex). It well known that free-living birds, including migratory species, have potential to disperse certain pathogenic microorganisms. has recently been introduced Europe and spreading through Austria, Hungary, Italy, Spain Switzerland, causing disease in birds humans. Like West Nile virus, USUV may...
After an outbreak of Chikungunya infection in Emilia-Romagna Region (North-eastern Italy), a survey was performed to estimate the seroprevalence antibody virus and proportion asymptomatic infections, identify factors associated with infection, evaluate performance surveillance system. The method used on random sample residents village largest number reported cases. prevalence 10.2% (33 325), being higher older people males, lower when window screens insect repellents were used. Only 18%...
Background Dengue fever results from infection with one or more of four different serotypes dengue virus (DENV). Despite the widespread nature this infection, available molecular diagnostics have significant limitations. The aim study was to develop a multiplex, real-time, reverse transcriptase-PCR (rRT-PCR) for detection, quantitation, and serotyping viruses in single reaction. Methodology/Principal Findings An rRT-PCR assay targeting 5′ untranslated region capsid gene DENV genome designed...
Originating from Africa, Usutu virus (USUV) first emerged in Europe 2001. This mosquito-borne flavivirus caused high mortality rates its bird reservoirs, which strongly resembled the introduction of West Nile (WNV) 1999 United States. Mosquitoes infected with USUV incidentally transmit to other vertebrates, including humans, can result neuroinvasive disease. and WNV co-circulate parts southern Europe, but distribution extends into central northwestern Europe. In field, both viruses have been...
Background In 2008, after the first West Nile virus (WNV) detection in Emilia-Romagna region, a surveillance system, including mosquito- and bird-based surveillance, was established to evaluate presence. Surveillance improved following years by extending monitoring larger areas increasing numbers of mosquitoes birds tested. Methodology/Principal Findings A network mosquito traps, evenly distributed regularly activated, set up within surveyed area. total 438,558 mosquitoes, grouped 3,111...
The mosquito-borne alphavirus, chikungunya virus (CHIKV), has recently reemerged, producing the largest epidemic ever recorded for this virus, with up to 6.5 million cases of acute and chronic rheumatic disease. There are currently no licensed vaccines CHIKV current anti-inflammatory drug treatment is often inadequate. Here we describe isolation characterization two human monoclonal antibodies, C9 E8, from infected recovered individuals. was determined be a potent neutralizing antibody...
Abstract One of the major concerns in COVID‐19 pandemic is related to possible transmission poorly ventilated spaces SARS‐CoV‐2 through aerosol microdroplets, which can remain air for long periods time and be transmitted others over distances >1 m. Cold atmospheric pressure plasmas represent a promising solution, thanks their ability producing blend many reactive species, inactivate airborne aerosolized microorganisms. In this study, dielectric barrier discharge plasma source used...
ABSTRACT A European multicenter study of immunoblotting for the serodiagnosis Lyme borreliosis showed considerable variation in results obtained from tests with a panel 227 serum samples. Six laboratories used different immunoblot methods, and wide range bands was detected all assays. Multivariable logistic regression analysis data individual to determine most discriminatory reliable detection antibodies Borrelia burgdorferi sensu lato. These were construct interpretation rules immunoblots...
Background/aims: The presence of selected bacteria ( Enterococcus faecalis , Porphyromonas gingivalis Prevotella intermedia Tannerella forsythensis Treponema denticola ) in infected root canals was studied using polymerase chain reaction (PCR) assays, and the association with clinical signs endodontic disease assessed. null hypothesis, that no difference could be observed between apical periodontitis a specific bacterial strain, tested. Methods: Microbial samples were obtained from 62 teeth...
Abstract Objective Human Lyme arthritis caused by Borrelia burgdorferi is characterized an inflammatory infiltrate that consists mainly of neutrophils and T cells. This study was undertaken to evaluate the role innate acquired immune responses elicited neutrophil‐activating protein A (NapA) B in patients with arthritis. Methods Serum anti‐NapA antibodies were measured 27 30 healthy control subjects. The cytokine profile synovial fluid cells specific for NapA investigated 5 induced monocytes...
Following a large West Nile virus (WNV) epidemic in northeastern Italy 2008, human and animal surveillance activities were implemented Emilia Romagna. Human was performed by serology or genome detection on blood cerebrospinal fluid for all suspected cases suffering from acute meningoencephalitis the regional territory. Animal consisted of passive active horses wild birds mosquitoes. Between 15 June 31 October 2009, nine 78 possible neuroinvasive disease confirmed (three fatal). From May to...
Neonatal sepsis can be classified into two subtypes depending upon whether the onset of symptoms is before 72 hours life (early-onset neonatal sepsis—EONS) or later (late-onset sepsis—LONS). These definitions have contributed greatly to diagnosis and treatment by identifying which microorganisms are likely responsible for during these periods expected outcomes infection. This paper focuses on tools that microbiologist offer diagnose eventually prevent sepsis. Here, we discuss advantages...