Eugenia Quirós-Roldán
A5033592492- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- HIV, Drug Use, Sexual Risk
- COVID-19 and healthcare impacts
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- Respiratory viral infections research
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2010-2025
University of Brescia
2016-2025
Brescia University
2005-2024
University of Siena
2016-2023
University of Padua
2021-2023
National Institutes of Health
2021
Hospital for Tropical Diseases
2003-2020
Cedars-Sinai Medical Center
2020
Bay Medical Center
2020
El Camino Hospital
2020
Remdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases, has shown in vitro activity against SARS-CoV-2. We provided remdesivir on compassionate-use basis to patients hospitalized with Covid-19, the illness caused by infection Patients were those confirmed SARS-CoV-2 who had an oxygen saturation of 94% or less while they breathing ambient air receiving support. received 10-day course remdesivir, consisting 200 mg administered intravenously day 1, followed 100 daily for...
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 987 patients with life-threatening disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), 13 types IFN-α (36), or both (52) onset critical disease; a few also auto-Abs other three type I IFNs. The neutralize ability corresponding IFNs to block...
The genetics underlying severe COVID-19 immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody dampens IFN response prevent damage from pathogen-induced inflammation. Two studies now examine likelihood affects risk of coronavirus disease 2019 (COVID-19) through components this (see Perspective by Beck Aksentijevich). Q....
Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute disease severity of 2019 (COVID-19). However, the utility specific immune-based biomarkers predict clinical outcome remains elusive. Here, we analyzed levels 66 soluble in 175 Italian patients with COVID-19 ranging from mild/moderate critical assessed type I IFN–, II NF-κB–dependent whole-blood transcriptional signatures. A broad signature was observed, implicating activation various...
Abstract In December 2019, an initial cluster of interstitial bilateral pneumonia emerged in Wuhan, China. A human-to-human transmission was assumed and a previously unrecognized entity, termed coronavirus disease-19 (COVID-19) due to novel (SARS-CoV-2) described. The infection has rapidly spread out all over the world Italy been first European country experiencing endemic wave with unexpected clinical severity comparison Asian countries. It shown that SARS-CoV-2 utilizes angiotensin...
T cells are involved in the early identification and clearance of viral infections also support development antibodies by B cells. This central role for makes them a desirable target assessing immune response to SARS-CoV-2 infection. Here, we combined two high-throughput profiling methods create quantitative picture T-cell SARS-CoV-2. First, at individual level, deeply characterized 3 acutely infected 58 recovered COVID-19 subjects experimentally mapping their CD8 through antigen stimulation...
Background: Recently, loss-of-function variants in TLR7 were identified two families which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the represent tip of iceberg a subset male patients. Methods: This is nested case-control study we compared participants with extreme phenotype selected from Italian GEN-COVID cohort SARS-CoV-2-infected (<60 y, 79 severe cases versus 77 control cases). applied LASSO Logistic...
Immune system aging is becoming a field of increasing public health interest because prolonged life expectancy, which not paralleled by an increase in expectancy. As age progresses, innate and adaptive immune systems undergo changes, are defined, respectively, as inflammaging senescence. A wealth available data demonstrates that these two conditions closely linked, leading to greater vulnerability elderly subjects viral, bacterial, opportunistic infections well lower post-vaccination...
We undertook this study to assess the association between various potential causes of liver disease in HIV-seropositive patients and mortality due failure. Three hundred eight in-hospital deaths were observed from 1987 December 1995 a prospectively followed cohort 1894 patients. For each subject, clinical data evaluated whether failure had substantially contributed mortality. A case control nested was then performed, which compared demographic variables at enrollment during follow-up who...
Country-specific forecasts of the growing non-communicable disease (NCD) burden in ageing HIV-positive patients will be key to guide future HIV policies. We provided first national for Italy and Unites States America (USA) quantified direct cost caring these increasingly complex patients.We adapted an individual-based model USA, which followed on HIV-treatment as they aged developed NCDs (chronic kidney disease, diabetes, dyslipidaemia, hypertension, non-AIDS malignancies, myocardial...
SARS-CoV-2 vaccination is recommended in patients with inborn errors of immunity (IEIs); however, little known about immunogenicity and safety these patients.
Abstract Toll-like receptors (TLR) are crucial components in the initiation of innate immune responses to a variety pathogens, triggering production pro-inflammatory cytokines and type I II interferons, which responsible for antiviral responses. Among different TLRs, TLR7 recognizes several single-stranded RNA viruses including SARS-CoV-2. We others identified rare loss-of-function variants X-chromosomal young men with severe COVID-19 no prior history major chronic diseases, that were...
Human bone marrow (BM) is a relevant site for immunoglobulin (Ig) generation in vivo. The occurrence of BM cells capable spontaneous and high rate Ig secretion 14 d vitro has been described previously. Accordingly, these provide suitable model studying terminal B cell maturation within the BM. We have reported recently that are not totally differentiated when isolated from body, as they require inductive signals adherent stromal to complete their maturation. Interleukin (IL)-6 produced by...