A5025785531- Iron Metabolism and Disorders
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Trace Elements in Health
- Amyotrophic Lateral Sclerosis Research
- Hemoglobinopathies and Related Disorders
- Hepatitis C virus research
- HIV-related health complications and treatments
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Hepatitis B Virus Studies
- Phytoestrogen effects and research
- Respiratory viral infections research
- Neurogenetic and Muscular Disorders Research
- Autophagy in Disease and Therapy
- Fatty Acid Research and Health
- Zebrafish Biomedical Research Applications
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
University of Brescia
2015-2024
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
1997-2024
University of Siena
2023
University of Padua
2023
Weatherford College
2021
Brescia University
2015-2021
Universidade Municipal de São Caetano do Sul
2017
Center for Translational Molecular Medicine
2015
Chongqing Electromechanical Holdings (China)
2015
Consorzio Interuniversitario per le Biotecnologie
1996-1997
Abstract Toll-like receptors (TLR) are crucial components in the initiation of innate immune responses to a variety pathogens, triggering production pro-inflammatory cytokines and type I II interferons, which responsible for antiviral responses. Among different TLRs, TLR7 recognizes several single-stranded RNA viruses including SARS-CoV-2. We others identified rare loss-of-function variants X-chromosomal young men with severe COVID-19 no prior history major chronic diseases, that were...
Prevalence of the recently discovered GB virus C (GBV -C) was evaluated in a cohort 49 Italian patients with acute or chronic hepatitis unknown etiology (non-A-E hepatitis) and control group 100 healthy blood donors. The GBV-C genomes could be detected by polymerase chain reaction (PCR) reverse transcription 35% 39% patients; only 1 subjects had positive response. All PCR products hybridized specific probe colorimetric assay, analysis sequences amplified cDNAs fully confirmed specificity...
Abstract Background: Hereditary hemochromatosis is a recessive disorder characterized by iron accumulation in parenchymal cells, followed organ damage and failure. The mainly attributable to the C282Y H63D mutations HFE gene, but additional HFE, transferrin receptor 2 (TfR2), hepcidin genes have been reported. copresence of different may explain phenotypic heterogeneity its variable penetrance. Methods: We used denaturing HPLC (DHPLC) for rapid DNA scanning (exons 2, 3, 4), hepcidin, TfR2 4...
The remarkable variability of response to vaccines against SARS-CoV-2 is apparent. present study aims estimate the extent which host genetic background contributes this in terms immune and side effects following administration BNT162b2 vaccine. We carried out a genome wide association (GWAS) by genotyping 873 Italian healthcare workers who underwent anti-SARS-CoV-2 vaccination with vaccine for whom information about spike antibodies titers were available. GWAS revealed significant between...
As most new medications, Cabotegravir (CAB) was recently approved as an antiretroviral treatment of HIV infection without in-depth safety information on in utero exposure. Although no developmental toxicity rats and rabbits reported, recent studies demonstrated that CAB decreases pluripotency human embryonic stem cells. exposure effects during development were assessed zebrafish embryos by the Fish Embryo Toxicity test after at subtherapeutic concentrations up to 25× Cmax. Larvae behavior...
Abstract Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus that caused an ongoing pandemic of pathology termed Disease 19 (COVID-19). Several studies reported both COVID-19 and RTEL1 variants are associated with shorter telomere length, but direct association between the two not generally acknowledged. Here we demonstrate up to 8.6% severe patients bear ultra-rare variants, show how this subgroup can be recognized. Methods A cohort 2246...
Abstract Background Nirmatrelvir, in combination with ritonavir, is one of the first orally available antiviral treatment for coronavirus disease 2019 (COVID‐19). Symptomatic pregnant women are at increased risk severe illness and complications that can affect developing baby. No malformations or lower embryo‐fetal survival have been observed when nirmatrelvir were administered to rats rabbits. Safety evaluation drugs used treating COVID‐19 also pregnancy urgent public health, then this...
Anemia is frequent during HIV infection and predictive of mortality. Although cART has demonstrated to reduce its prevalence, several patients still experience unresolved anemia. We aimed characterize iron homeostasis inflammation in HIV-infected individuals with mild anemia relation cART. In this retrospective cohort study, anemia, CD4+ cells > 200/mm3 at baseline, maintaining virological response for 12 months after starting were selected within the Standardized Management Antiretroviral...
Cereals are suggested to be the most important sources of lignan in diets western populations. Recent epidemiological studies show that European subpopulations which major source lignans cereals, display lower disease frequency regarding metabolic and cardiovascular diseases. The biological mechanisms several. Beyond their antioxidant anti-inflammatory actions at nutritional doses some regulate activity specific nuclear receptors (NRs), such as estrogen (ERs), also NRs central switches...
KIF5A encodes the heavy chain A of kinesin; motor protein involved in motility functions within neuron. Mutations N-terminal domain are known to cause SPG10; An autosomal dominant hereditary spastic paraplegia (HSP), as well rare Charcot-Marie-Tooth disease 2 (CMT2) cases. Recently C-terminal cargo-binding tail mutations have been associated with an amyotrophic lateral sclerosis (ALS) phenotype. Here we describe a subject presenting atypical slowly progressive syndrome evolving over period 4...