A5102788656- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- Toxoplasma gondii Research Studies
- Hemoglobinopathies and Related Disorders
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- interferon and immune responses
- Long-Term Effects of COVID-19
- Adenosine and Purinergic Signaling
- COVID-19 epidemiological studies
- Liver Disease Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Biochemical and Molecular Research
- Signaling Pathways in Disease
- Pancreatic function and diabetes
- Telemedicine and Telehealth Implementation
- Educational and Social Studies
- Telomeres, Telomerase, and Senescence
- Immune cells in cancer
- Ocular Diseases and Behçet’s Syndrome
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Italian Social Issues and Migration
University of Bari Aldo Moro
2025
AULSS 2 Marca Trevigiana
2021-2024
Casa Sollievo della Sofferenza
2023
University of Brescia
2010-2023
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2010-2023
University of Padua
2021-2022
Azienda Ospedaliera Universitaria Senese
2021
University of Siena
2021
Brescia University
2020
Harvard University
2013-2015
Age is a major risk factor in age-related macular degeneration (AMD), but the underlying cause unknown. We find increased Rho-associated kinase (ROCK) signaling and M2 characteristics eyes of aged mice, revealing immune changes aging. ROCK isoforms determine macrophage polarization into M1 subtypes. M2-like macrophages accumulated AMD, not normal eyes, suggesting that these may be linked to degeneration. injected mouse eye exacerbated choroidal neovascular lesions, while ameliorated them,...
The lymphocytic ionotropic purinergic P2X receptors (P2X1R-P2X7R, or P2XRs) sense ATP released during cell damage-activation, thus regulating T-cell activation. We aim to define the role of P2XRs islet allograft rejection and establish a novel anti-P2XRs strategy achieve long-term function. Our data demonstrate that P2X1R P2X7R are induced in allograft-infiltrating cells, only is increasingly expressed alloimmune response, augmented both allogeneic syngeneic transplantation. In vivo...
This study aimed to describe the longitudinal evolution of neutralizing antibody titres (NtAb) in three different cohorts healthcare workers (HCWs), including vaccinated HCWs with and without a previous SARS-CoV-2 infection previously infected unvaccinated HCWs. COVID-19 was mild or asymptomatic those experiencing infection.NtAb tested before BNT162b2 mRNA vaccine (V0), 20±2 days after first dose (V1_20), 20±3 (V2_20) 90±2 (V2_90) second about 2 months (N_60), 10 (N_300) 13 (N_390) from...
ObjectivesTo measure SARS-CoV-2 neutralizing antibody (NtAb) titres in previously infected or uninfected health care workers who received one two doses of BNT162b2 mRNA COVID-19 vaccine.MethodsNtAbs were titrated as dose-inhibiting 50% virus replication (ID50) by live microneutralization. We evaluated 41 recovering from mild asymptomatic infection at first vaccination dose (T1_inf) and 21 days later (T2_inf). Sixteen 20 after (T2_uninf) second vaccine (T3_uninf).ResultsAt T2_inf, but not...
The optimal treatment of a severe hemodynamic instability from shock to cardiac arrest in late term pregnant women is subject ongoing studies. However, there an increasing evidence that early "separation" between the mother and foetus may increase restoration status and, setting, it raise likelihood return spontaneous circulation (ROSC) mother. This treatment, called Perimortem Cesarean Section (PMCS), now termed as Resuscitative Hysterotomy (RH) better address issue section (C-section)....
Abstract Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus that caused an ongoing pandemic of pathology termed Disease 19 (COVID-19). Several studies reported both COVID-19 and RTEL1 variants are associated with shorter telomere length, but direct association between the two not generally acknowledged. Here we demonstrate up to 8.6% severe patients bear ultra-rare variants, show how this subgroup can be recognized. Methods A cohort 2246...
Abstract The clinical manifestations of SARS-CoV-2 infection vary widely among patients, from asymptomatic to life-threatening. Host genetics is one the factors that contributes this variability as previously reported by COVID-19 Genetics Initiative (HGI), which identified sixteen loci associated with severity. Herein, we investigated genetic determinants mortality, performing a case-only genome-wide survival analysis, 60 days after infection, 3904 patients GEN-COVID and other European...
The role of the novel costimulatory molecule TIM4 in anti-islet response is unknown. We explored expression and targeting Th1 (BALB/c islets into C57BL/6 mice) Th2 Tbet(-/-) models alloimmune a model autoimmune (diabetes onset NOD mice). TIM4, using monoclonal antibody RMT4-53, promotes islet graft survival model, with 30% surviving long term; protection appears to be mediated by skewing immune response. Differently, precipitates rejection further enhancing effect anti-TIM4 treatment...
We describe the time course of neutralizing antibody (NtAb) titer in a cohort health care workers with mild or asymptomatic severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. NtAb levels decreased over time; however, serum activity remained detectable after median 7 months from SARS-CoV-2 diagnosis majority cases.
We report the time course of neutralizing antibody (NtAb) response, as measured by authentic virus neutralization, in healthcare workers (HCWs) with a mild or asymptomatic SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection diagnosed at onset pandemic, no reinfection throughout and after three-dose schedule BNT162b2 mRNA vaccine an overall follow-up almost two years since infection. Forty-eight HCWs (median age 47 years, all immunocompetent) were evaluated: 29 (60.4%)...
This study aims to assess the effect of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor (ARBs) on course COVID-19. It is a prospective 221 (M/F ratio= 143/78, mean age 72±13) consecutive hypertensive patients with COVID-19: 76 (34.4%) treated ACEIs, 63 (28.5%) ARBs 82 (37.1%) antihypertensives OTHER than ACEIs or ARBs. They were all followed up until discharge death. BAD outcome was defined as need for invasive mechanical ventilation The three classes medication...
We described the long-term decay of neutralizing antibody (NtAb) to wild-type and Delta SARS-CoV-2 variant after three antigen stimulations (mild or asymptomatic natural infection followed by two doses BNT162b2 mRNA vaccine a median 296 days) in immunocompetent healthcare workers (HCWs). Live virus microneutralization against B.1 variants was performed VERO E6 cell cultures. The NtAb titers for were comparable highly correlated at both 20 200 days second dose 23 HCWs enrolled (median age, 46...
We aimed to investigate neutralizing antibody titers (NtAbT) the P.1 and B.1 SARS-CoV-2 variants in a cohort of healthy health care workers (HCW), including 20 previously infected individuals tested at baseline (BLinf, after median 298 days from diagnosis) 21 receiving one vaccine dose (D1inf) 15 uninfected subjects second-dose vaccination (D2uninf). All received BNT162b2 vaccination. D1inf NtAbT increased significantly with respect BLinf against both variants, fold-change higher for P.1....