A5026255423- Retinal Diseases and Treatments
- Endometriosis Research and Treatment
- Retinal Imaging and Analysis
- Uterine Myomas and Treatments
- Glaucoma and retinal disorders
- Minimally Invasive Surgical Techniques
- Retinal and Optic Conditions
- Ovarian cancer diagnosis and treatment
- CNS Lymphoma Diagnosis and Treatment
- Gynecological conditions and treatments
- Intraocular Surgery and Lenses
- Endometrial and Cervical Cancer Treatments
- Retinal and Macular Surgery
- Lymphatic System and Diseases
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Corneal Surgery and Treatments
- Autoimmune Neurological Disorders and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Connective Tissue Growth Factor Research
- Soft tissue tumor case studies
- Advanced Glycation End Products research
- Appendicitis Diagnosis and Management
- Epigenetics and DNA Methylation
Harbin Medical University
2013-2025
Second Affiliated Hospital of Harbin Medical University
2013-2025
Peking Union Medical College Hospital
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
North University of China
2024
Ministry of Education of the People's Republic of China
2024
Jinan University
2024
First Hospital of China Medical University
2020
China Medical University
2020
Harvard University
2010-2019
Age is a major risk factor in age-related macular degeneration (AMD), but the underlying cause unknown. We find increased Rho-associated kinase (ROCK) signaling and M2 characteristics eyes of aged mice, revealing immune changes aging. ROCK isoforms determine macrophage polarization into M1 subtypes. M2-like macrophages accumulated AMD, not normal eyes, suggesting that these may be linked to degeneration. injected mouse eye exacerbated choroidal neovascular lesions, while ameliorated them,...
<h3>Objective</h3> To describe the detailed clinical characteristics, immunotherapy, and long-term outcomes of patients with anti-NMDA receptor (NMDAR) encephalitis in China. <h3>Methods</h3> A single-center, prospective study. Patients who met diagnostic criteria were enrolled from 2011 to 2017 followed up. The features, treatment, collected prospectively. Factors affecting prognosis analyzed. <h3>Results</h3> study included 220 patients. most common presentations psychosis (82.7%) seizures...
The pathogenesis of diabetic retinopathy (DR) in metabolic syndrome (MetS) and type 2 diabetes (T2D) is not well studied, partly because an appropriate model has been developed. Recently, we introduced a novel spontaneous T2D MetS that replicates the relevant features human disease. In current study, investigated retinal vascular changes these animals. Experimental DR streptozotocin (STZ)-injected rodents described as inflammatory disease, which intercellular adhesion molecule 1 (ICAM-1)...
To compare the efficacy and safety of conbercept ranibizumab when administered according to a treat-and-extend (TREX) protocol for treatment neovascular age-related macular degeneration (AMD) in China. Between May 2014 2015, 180 patients were treated 1 : ratio using or from four hospitals. Patients received either 0.5 mg intravitreal injections. Follow-up time was year based on TREX approach. Main outcomes measures include best-corrected visual acuity (BCVA), Early Treatment Diabetic...
Abstract Single-port laparoscopy has gained more attention, but inherent technical challenges hinder its wider use. To overcome the disadvantage of traditional single-port surgery, robotic laparoendoscopic single-site surgery system was designed and clinically utilized. This multi-center single-arm trial aimed to present clinical outcomes SHURUI endoscopic system. 63 women with ovary cysts, myoma, cervical epithelial neoplasm, or endometrial carcinoma were recruited at 6 academic medical...
Diabetic retinopathy (DR), a microvascular disorder linked to diabetes, is on the rise globally. Oxidative stress and immune cell infiltration are illness initiation progression, according recent study. This study investigated biomarkers connected DR oxidative their connection with using bioinformatics analysis found possible therapeutic medications. The Gene Expression Omnibus (GEO) database was used obtain gene expression data for DR. Differentially expressed genes (DEGs) (OS)-related were...
To compare the genetic characteristics of normal control group to those neovascular age-related macular degeneration (AMD) patients and detect single-nucleotide polymorphisms (SNPs) related pathogenesis AMD sensitivity anti-VEGF drug, combercept. This is a prospective case-controlled study. A total 104 were treated with combercept 106 subjects served as group. SNPs associated disease susceptibility drug analysed. Significant differences existed between among genotypes two genes, ARMS2...
Diabetic retinopathy (DR) is a microvascular complication of diabetes and leading cause vision loss. Biomarkers methods for early diagnosis DR are urgently needed. Using new molecular imaging approach, we show up to 94% higher accumulation custom designed probes against vascular endothelial growth factor receptor 2 (VEGFR-2) in retinal choroidal vessels diabetic animals (P<0.01), compared normal controls. More than 80% the VEGFR-2 retina was capillaries, 47% controls (P<0.01). Angiography...
Our study aims to investigate the distribution of pain symptoms and association between clinical parameters in patients with adenomyosis.The pathological data 291 diagnosed adenomyosis Obstetrics Gynecology Department Peking Union Medical College Hospital from March 2012 September 2015 were collected, analyzed regard symptoms.The median age at disease onset was 34 years. 71.8% had (pain group) 28.2% no (painless group). Patients accompanied by dysmenorrhea accounted for 68%, among which...
Abstract Diabetic retinopathy (DR) is a diabetes-associated complication that poses threat to vision, distinguished by persistent and mild inflammation of the retinal microvasculature. The activation microglia plays crucial role in driving this pathological progression. Previous investigations have demonstrated ubiquitin-specific peptidase 25 (USP25), deubiquitinating enzyme, involved regulation immune cell activity. Nevertheless, precise mechanisms through which USP25 contributes...
By identifying molecular biological markers linked to cuproptosis in diabetic retinopathy (DR), new pathobiological pathways and more accessible diagnostic can be developed.
Vitreoretinal lymphoma (VRL) remains a diagnostic challenge due to its scarce prevalence, and delayed diagnosis usually results in blindness even fatal outcomes. Herein, an artificial intelligence (AI) system is developed identify VRL among 16 retinal diseases conditions on optical coherence tomography (OCT) images with the cross‐subject meta‐transfer learning (CS‐MTL) algorithm. Extensive experiments of few‐shot recognition tasks prove robustness our model 1‐, 3‐, 5‐shot scenarios,...
The aim of this study was to investigate the appropriate measures for diagnosing and treating perineal endometriosis (PEM) with anal sphincter involvement.Between January 1992 April 2011, clinical features, diagnosis management 31 patients who were diagnosed PEM involvement at Peking Union Medical College Hospital retrospectively analyzed using their records. A range 6-78 months outpatient follow-up after surgery conducted these but extended by telephone interviews 29 in December 2011.All...
Cathepsin B (CtsB) contributes to atherosclerosis and cancer progression by processing the extra-cellular matrix promoting angiogenesis. Although CtsB was reported promote reduce angiogenesis, there is no mechanistic explanation that reconciles this apparent discrepancy. cleaves CD18 from surface of immune cells, but its contribution angiogenesis has not been studied. We developed an in vivo technique for visualization cell transmigration corneal vessels toward implanted cytokines. Wild-type...
Objectives: To investigate the clinical characteristics, treatment and prognosis of leiomyomatosis peritonealis disseminata (LPD) following laparoscopic surgery with uncontained morcellation to summarize features iatrogenic LPD based on published literature together our own experience. Methods: A cohort 13 cases diagnosed treated in Peking Union Medical College Hospital from 2011 2020 was reported focusing prognosis. Results: All patients had a history myomectomy morcellation. The average...
Retinal ischemia-reperfusion (I/R) serves as a significant contributor to ocular diseases, triggering cascade of pathological processes. The interplay between neuroinflammation and the apoptosis retinal ganglion cell (RGC) is well-explored aspect I/R-induced tissue damage. Within this intricate landscape, inflammatory cytokine Interleukin-21 (IL21) emerges potent mediator with known detrimental effects on neuronal integrity. However, its specific impact RGC in context I/R has remains be...