A5076031173- IgG4-Related and Inflammatory Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Oral and Maxillofacial Pathology
- Eosinophilic Disorders and Syndromes
- Soft tissue tumor case studies
- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Cardiovascular Effects of Exercise
- Bone health and treatments
- Pancreatic function and diabetes
- Vasculitis and related conditions
- Cardiac tumors and thrombi
- Bone Tumor Diagnosis and Treatments
- Histiocytic Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Gastrointestinal disorders and treatments
- Cardiomyopathy and Myosin Studies
- Cardiac Fibrosis and Remodeling
- Cardiac Structural Anomalies and Repair
- Autoimmune and Inflammatory Disorders
- Otitis Media and Relapsing Polychondritis
University of Parma
2016-2025
University Hospitals Parma Medical Center
1999-2016
Creative Commons
2016
Piedmont University
2016
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2016
Centro Laser
2014
Harvard University
2012
Boston Children's Hospital
2012
University of Miami
2012
Vita-Salute San Raffaele University
2012
Background —Inflammation is an important component of ischemic heart disease. PTX3 a long pentraxin whose expression induced by cytokines in endothelial cells, mononuclear phagocytes, and myocardium. The possibility that altered patients with acute myocardial infarction (AMI) has not yet been tested. Methods Results —Blood samples were collected from 37 admitted to the coronary care unit (CCU) symptoms AMI. plasma concentrations, as measured ELISA, higher than mean+2 SD age-matched controls...
Abstract Aims The concept of “atrial cardiomyopathy” (AtCM) had been percolating through the literature since its first mention in 1972. Since then, publications using term were sporadic until decision was made to convene an expert working group with representation from four multinational arrhythmia organizations prepare a consensus document on atrial cardiomyopathy 2016 (EHRA/HRS/APHRS/SOLAECE cardiomyopathies: definition, characterization, and clinical implication). Subsequently, AtCM have...
Podocyte injury and resulting albuminuria are hallmarks of diabetic nephropathy, but targeted therapies to halt or prevent these complications currently not available. Here, we show that the immune-related molecule B7-1/CD80 is a critical mediator podocyte in type 2 nephropathy. We report induction B7-1 kidney biopsy specimens from patients with diabetes. Genetic epidemiologic studies revealed association two single nucleotide polymorphisms at gene Furthermore, increased levels soluble...
Immunologically based clinical trials performed thus far have failed to cure type 1 diabetes (T1D), in part because these approaches were nonspecific. Because the disease is driven by autoreactive CD4 T cells, which destroy β transplantation of hematopoietic stem and progenitor cells (HSPCs) has been recently offered as a therapy for T1D. Our transcriptomic profiling HSPCs revealed that are deficient programmed death ligand (PD-L1), an important immune checkpoint, T1D nonobese diabetic (NOD)...
The atria provide an important contribution to cardiac function [1], [2]. Besides their impact on ventricular filling, they serve as a volume reservoir, host pacemaker cells and parts of the conduction system (e.g. sinus node, AV node), secrete natriuretic peptides like atrial peptide (ANP) brain (BNP) that regulate fluid homoeostasis. Atrial myocardium is affected by many non-cardiac conditions [3] is, in some respects, more sensitive than [4]. are activated, besides three specialised...
Mechanisms by which mucosal regeneration is abrogated in inflammatory bowel disease (IBD) are still under investigation, and a role for an intestinal stem cell (ISC) defect now emerging. Herein, we report abnormal ISC death that occurs Crohn's disease, exacerbates colitis, limits ISC-dependent repair, controlled through the factor Transmembrane protein 219 (TMEM219). Large alterations TMEM219 expression were observed patients with particularly those active and/or who nonresponders to...
Background —The activation of B 2 receptors by kinins could exert cardioprotective effects in myocardial ischemia and heart failure. Methods Results —To test whether the absence bradykinin may affect cardiac structure function, we examined developmental changes blood pressure (BP), rate, morphology receptor gene knockout (B −/− ), heterozygous +/− wild-type +/+ ) mice. The BP mice, which was still normal at 50 days age, gradually increased, reaching a plateau 6 months (136±3 versus 109±1 mm...
Ear, nose and throat (ENT) involvement is common in Churg-Strauss syndrome (CSS), usually manifesting as allergic rhinitis chronic rhinosinusitis with or without polyps. Otolaryngologists may play a pivotal role making an early diagnosis of this disease.CSS systemic vasculitic disorder that affects small to medium-sized blood vessels. Although the cause CSS remains unknown, tissue damage seems more likely be mediated by activated eosinophils. Patients affected frequently have ENT...
Abstract Context: Obesity is frequently associated with left ventricular hypertrophy, even when uncomplicated by hypertension or diabetes mellitus. Left hypertrophy an important risk factor for congestive heart failure. Objective: The objective of this study was to evaluate the relationship between leptin and mass in uncomplicated, morbid (grade 3) obesity existence receptors intracellular signaling proteins human heart. Design: (LVM) calculated through electrocardiogram reading normotensive...