A5086254990- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Cardiomyopathy and Myosin Studies
- Electrospun Nanofibers in Biomedical Applications
- Lung Cancer Treatments and Mutations
- Cardiac electrophysiology and arrhythmias
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nitric Oxide and Endothelin Effects
- HER2/EGFR in Cancer Research
- Cardiovascular Effects of Exercise
- Pulmonary Hypertension Research and Treatments
- Colorectal Cancer Treatments and Studies
- Eicosanoids and Hypertension Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Chronic Myeloid Leukemia Treatments
- Lymphatic System and Diseases
- Mesenchymal stem cell research
- Thermoregulation and physiological responses
University of Parma
2016-2025
Ospedale di Parma
2011
NIHR Bristol Cardiovascular Biomedical Research Unit
2010
Charité - Universitätsmedizin Berlin
2010
University of Bristol
2010
Pathological Society
2007
Gruppo di Ricerca Geriatrica
2004
Istituto Nazionale Biostrutture e Biosistemi
2003
University of Sassari
2003
University Hospitals Parma Medical Center
2003
Nerve growth factor (NGF) promotes angiogenesis and cardiomyocyte survival, which are both desirable for postinfarction myocardial healing. Nonetheless, the NGF potential cardiac repair has never been investigated.To define expression localization of its high-affinity receptor TrkA (tropomyosin-related A) in human infarcted heart to investigate roles endogenous engineered using a mouse model infarction (MI).Immunostaining was performed on samples from humans deceased MI or unrelated...
AZD9291 (osimertinib) is an irreversible third-generation EGFR tyrosine kinase inhibitor (TKI) with impressive tumor responses in EGFRT790M-mutated NSCLC.1 The selectivity of for T790M depends on its covalent interaction cysteine 797 the adenosine triphosphate-binding cleft. Mutation at C797 codon, such as missense variant C797S, has been demonstrated principal mechanism acquired resistance to TKIs.2 Little known about alternative mechanisms.
Proliferating cell nuclear antigen (PCNA) is a late growth-regulated gene that expressed at the G1-S boundary of cycle and required for DNA synthesis proliferation. Since quantitative results suggest myocyte hyperplasia occurs in decompensated human heart, we postulated induction PCNA may be present failing heart humans. protein was detected myocardial samples obtained from left right ventricles patients with congestive failure. Endomyocardial biopsies collected donor subjects were used as...
To determine whether cardiac failure produced by chronic coronary artery stenosis was associated with the activation of myocyte cellular hyperplasia in myocardium, changes number and size left ventricular myocytes were measured rats 3 months after surgery. The hypertrophied ventricle found to possess 44%, 32%, 49%, 48% fewer mononucleated, binucleated, trinucleated, tetranucleated myocytes, respectively. In contrast, right contained 1.49 x 10(6) more as a result 2.1-fold, 1.4-fold, 1.4-fold...
To evaluate the effects of hypertension on cardiac hypertrophy, myocardial structure, and ventricular arrhythmias, 27 3-month-old spontaneously hypertensive rats were treated with enalapril (10 mg/kg) daily for 11 months compared 26 untreated control rats. Systolic arterial pressure was significantly decreased in rats, at end experiment, it 199 +/- 3 mm Hg (treated) versus 237 (controls) (p less than 0.001). At this time, spontaneous arrhythmias induced either by programmed electrical...
To determine the effects of long-term pressure overload on structural mechanisms implicated in wall remodeling right ventricle, a mild pulmonary artery banding was applied to rats approximately 2 months old, and animals were killed 150 days later. The surgical procedure resulted 60% reduction cross-sectional area constricted vessel 52% increase weight ventricle. hypertrophic myocardial response associated with an elevation ventricular systolic (from 33 +/- 11 mm Hg 71 12 Hg), end-diastolic 3...
Emerging evidence suggests that both adult cardiac cell and the stem/progenitor (CSPC) compartments are involved in patho-physiology of diabetic cardiomyopathy (DCM). We evaluated whether early administration Resveratrol, a natural antioxidant polyphenolic compound, addition to improving cardiomyocyte function, exerts protective role on (i) progenitor pool, (ii) myocardial environment its impact CSPCs, positively interfering with onset DCM phenotype. Adult Wistar rats (n = 128)...
Interleukin-1α (IL-1α) released by dying cells is an alarmin that activates the innate immunity. We hypothesized after myocardial ischemia-reperfusion (I/R) injury, IL-1α amplifies damage activating inflammasome and caspase-1.Adult male CD1 mice were used. The left anterior descending coronary artery was ligated for 30 minutes, 24 hours of reperfusion. An blocking antibody (15 μg/kg intraperitoneally) or matching vehicle given A subgroup underwent sham surgery. assessed effects blockade on...
Experimental and clinical evidence suggests kinin involvement in adaptive myocardial growth. Kinins are growth-inhibitory to cardiomyocytes. Knockout of B2 receptor (B2R) signaling causes dilated failing cardiomyopathy 129/J mice, a 9-bp deletion polymorphism human B2R is associated with reduced expression exaggerated left ventricular growth response physical stress. We reasoned that genetic background aging may significantly influence the impact mutation on cardiac phenotype. The theory was...
To determine whether anemia-induced cardiac hypertrophy affects ventricular size and shape the component structures of capillary network left right ventricles, young male rats were fed an iron- copper-deficient diet for 7 weeks. By that time, blood hemoglobin content fell to 5 +/- 1 g/dl, packed cell volume 18 3%. further characterize implications anemia, red number, corpuscular content, systemic arterial pressure, heart rate, viscosity measured. Moreover, changes in weights analyzed terms...
To determine whether a prolonged duration of mechanical load on the ventricular myocardium leads to capillary proliferation, constriction pulmonary artery was produced in rats at 3 mo age, and hearts were examined 200 days later. Functionally, elevations right systolic pressure, from 30 +/- 12 67 11 mmHg, end-diastolic 2.4 1.4 8.6 found. Anatomically, 69% enlargement mass observed, this hypertrophic growth characterized by 78% thickening wall with no change area, latter calculated quotient...
Recent results of the FLAURA trial showed a better progression-free survival for patients treated with osimertinib, new third-generation EGFR tyrosine kinase inhibitor, than when gefitinib or erlotinib is used as first-line treatment EGFR-mutated NSCLC, opening scenario osimertinib first therapeutic option.1Soria J.C. Ohe Y. Vansteenkiste J. et al.Osimertinib in untreated advanced non-small-cell lung cancer.N Engl J Med. 2018; 378: 113-125Google Scholar Unfortunately, experienced disease...
Abstract OBJECTIVES Tumour-infiltrating lymphocytes (TILs) are critically implicated in the clinical outcome and response to immunotherapy non-small-cell lung cancer (NSCLC) patients. The functional competence of lymphocyte subpopulations is strongly conditioned by their spatial arrangement within tumour immune microenvironment. aim this study was determine whether tissue localization specific TIL might have an impact on risk recurrence surgically resected NSCLC. METHODS High-speed scanning...
Darier′s disease (DD) is a rare, autosomal dominant genodermatosis caused by pathogenic variants in the ATP2A2 gene, which encodes SERCA2 protein, an endoplasmic reticulum ATPase Ca2+ transporter. These mutations impair intracellular calcium homeostasis leading to increased protein misfolding, (ER) stress response, and activation of unfolded response (UPR), culminating keratinocyte apoptosis anomalies interfollicular epidermal stratification. Clinically, characterized presence skin lesions...
In 47 male adult Wistar rats with 4-wk aortic coarctation (AC) and 39 age-matched sham-operated (SO) chronically instrumented for telemetry electrocardiogram recording, we investigated the mechanisms of arrhythmogenesis in moderate cardiac hypertrophy, an approach from “in vivo” toward cellular level, analyzing 1) stress-induced arrhythmias all 2) myocardial fibrosis 35 animals action potential duration density hyperpolarization-activated current 19 others at ventricular level. Aortic...
Heart repair by stem cell treatment may involve life-threatening arrhythmias. Cardiac progenitor cells (CPCs) appear best suited for reconstituting lost myocardium without posing arrhythmic risks, being commissioned towards cardiac phenotype. In this study we tested the hypothesis that mobilization of CPCs through locally delivered Hepatocyte Growth Factor and Insulin-Like Factor-1 to heal chronic myocardial infarction (MI), lowers proneness We used 133 adult male Wistar rats either with...
The recent introduction of stem cells in cardiology provides new tools understanding the regenerative processes normal and pathological heart has opened a search for therapeutic strategies. Recent published reports have contributed to identifying possible cellular therapy approaches generate myocardium, involving transcoronary intramyocardial injection progenitor cells. However, one limiting factors overall interpretation clinical results obtained by cell is represented lack...
c-Kit(pos) cardiac progenitor cells (CPCs) represent a successful approach in healing the infarcted heart and rescuing its mechanical function, but electrophysiological consequences are uncertain. CPC mobilization promoted by hepatocyte growth factor (HGF) IGF-1 improved electrogenesis myocardial infarction (MI). We hypothesized that locally delivered CPCs supplemented with HGF + (GFs) can concur ameliorating electrical stability of regenerated heart. Adult male Wistar rats (139 rats)...
In cells derived from several types of cancer, a transcriptional program drives high consumption glutamine (Gln), which is used for anaplerosis, leading to metabolic addiction the amino acid. Low or absent expression Glutamine Synthetase (GS), only enzyme that catalyzes de novo Gln synthesis, has been considered marker Gln-addicted cancers. this study, two human cell lines brain tumors with oligodendroglioma features, HOG and Hs683, have shown be GS-negative. Viability both depends...