Sabino Scolletta
A5055739492- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Function and Risk Factors
- Renal function and acid-base balance
- Cardiac and Coronary Surgery Techniques
- Thermal Regulation in Medicine
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Ultrasound in Clinical Applications
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Airway Management and Intubation Techniques
- Cardiac Ischemia and Reperfusion
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
University of Siena
2016-2025
Azienda Ospedaliera Universitaria Senese
2017-2023
Université Libre de Bruxelles
2011-2022
Erasmus Hospital
2012-2022
Ospedale Santa Maria alle Scotte
2007-2020
Guglielmo da Saliceto Hospital
2016
University of Florence
2009-2012
Royal Victoria Hospital
2012
University of Ulster
2012
Mie University Hospital
2012
Sepsis induces microvascular alterations that may play an important role in the development of organ dysfunction. However, relationship these to systemic variables and outcome is still not well defined. We investigated which factors influence microcirculatory patients with severe sepsis whether are independently associated mortality.Analysis prospectively collected data from previously published studies by our group.A 36-bed, medicosurgical university hospital Department Intensive Care.A...
Abstract In December 2019, an initial cluster of interstitial bilateral pneumonia emerged in Wuhan, China. A human-to-human transmission was assumed and a previously unrecognized entity, termed coronavirus disease-19 (COVID-19) due to novel (SARS-CoV-2) described. The infection has rapidly spread out all over the world Italy been first European country experiencing endemic wave with unexpected clinical severity comparison Asian countries. It shown that SARS-CoV-2 utilizes angiotensin...
Background: Recently, loss-of-function variants in TLR7 were identified two families which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the represent tip of iceberg a subset male patients. Methods: This is nested case-control study we compared participants with extreme phenotype selected from Italian GEN-COVID cohort SARS-CoV-2-infected (<60 y, 79 severe cases versus 77 control cases). applied LASSO Logistic...
Abstract Introduction The aim of this study was to evaluate the incidence and determinants AKI in a large cohort cardiac arrest patients. Methods We reviewed all patients admitted, for at least 48 hours, our Dept. Intensive Care after CA between January 2008 October 2012. defined as oligo-anuria (daily urine output <0.5 ml/kg/h) and/or an increase serum creatinine (≥0.3 mg/dl from admission value within hours or 1.5 time baseline level). Demographics, comorbidities, details, ICU...
Severe acute respiratory syndrome coronavirus 2-induced direct cytopathic effects against type I and II pneumocytes mediate lung damage. Krebs von den Lungen-6 (KL-6) is mainly produced by damaged or regenerating alveolar pneumocytes. This preliminary study analyzed serum concentrations of KL-6 in patients with disease (COVID-19) to verify its potential as a prognostic biomarker severity. Twenty-two (median age [interquartile range] 63 [59-68] years, 16 males) COVID-19 were enrolled...
Abstract Toll-like receptors (TLR) are crucial components in the initiation of innate immune responses to a variety pathogens, triggering production pro-inflammatory cytokines and type I II interferons, which responsible for antiviral responses. Among different TLRs, TLR7 recognizes several single-stranded RNA viruses including SARS-CoV-2. We others identified rare loss-of-function variants X-chromosomal young men with severe COVID-19 no prior history major chronic diseases, that were...
The Coronavirus disease (COVID-19) pandemic is causing millions of infections and hundreds thousands deaths worldwide. Cumulative clinical laboratory evidence suggest that a subset patients with severe COVID-19 may develop cytokine storm syndrome during the course disease, respiratory impairment requiring ventilatory support. One field research nowadays to identify treat viral-induced hyperinflammation drugs used in other conditions characterized by an status. These might help reduce COVID19...
SARS-CoV2-induced direct cytopathic effects against type II pneumocytes are suspected to play a role in mediating and perpetuating lung damage. The aim of this study was evaluate serum KL-6 behavior COVID-19 patients investigate its potential predicting clinical course. Sixty (median age IQR, 65 (52-69), 43 males), hospitalized for at Siena COVID Unit University Hospital, were prospectively enrolled. Twenty-six selected 63 (55-71), 16 males); all them underwent follow-up evaluations,...
Abstract Background Diaphragmatic dysfunction is a major factor responsible for weaning failure in patients that underwent prolonged invasive mechanical ventilation acute severe respiratory from COVID-19. This study hypothesizes ultrasound measured diaphragmatic thickening fraction (DTF) could provide corroborating information COVID-19 ventilation. Methods was an observational, pragmatic, cross-section, multicenter 6 Italian intensive care units. DTF assessed undergoing 1st March 2020 to...