A5050239368- Sulfur Compounds in Biology
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Amino Acid Enzymes and Metabolism
- Folate and B Vitamins Research
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Redox biology and oxidative stress
- Cancer Research and Treatments
- Polyamine Metabolism and Applications
- Liver Disease and Transplantation
- Vitamin C and Antioxidants Research
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Nitric Oxide and Endothelin Effects
- Multiple Myeloma Research and Treatments
- Organ Transplantation Techniques and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Atrial Fibrillation Management and Outcomes
- Biopolymer Synthesis and Applications
- Glutathione Transferases and Polymorphisms
- Analytical Methods in Pharmaceuticals
- COVID-19 Clinical Research Studies
University of Pisa
2016-2025
Fondazione Toscana Gabriele Monasterio
2011-2023
Scuola Superiore Sant'Anna
2023
Azienda Ospedaliera Universitaria Pisana
2004-2022
Ospedale Santa Chiara
2017-2021
Istituto di Fisiologia Clinica
2004-2017
Regione Toscana
2011-2012
National University of Mar del Plata
2010
National Research Council
2004-2005
University of Siena
2000
Ex situ normothermic machine perfusion (NMP) might minimize ischemia/reperfusion injury (IRI) of liver grafts. In this study, 20 primary transplantation recipients older grafts (≥70 years) were randomized 1:1 to NMP or cold storage (CS) groups. The study endpoint was evaluate graft and patient survival at 6 months posttransplantation. secondary bile duct biopsies; IRI by means peak transaminases within 7 days after surgery; incidence biliary complications month 6. Liver biopsies collected...
It has been reported in several cell lines that exposure to low levels of reactive oxygen species can exert a stimulatory effect on their proliferation. We have previously shown mild oxidative conditions also counteract apoptotic stimuli. A constitutive cellular production superoxide and hydrogen peroxide originates from various sources; among these, gamma-glutamyl transpeptidase (GGT), the plasma membrane-bound activity charge metabolizing extracellular reduced glutathione, recently...
Over the last decade, there has been a heightened awareness and an increase in amount of literature being published on recognition prediction difficult airway. During preoperative evaluation airway, thorough history physical specifically related to airway should be performed. Various measurements anatomic features noninvasive clinical tests can performed enhance this assessment. In study we correlated Mallampati modified score several other indexes with laryngoscopic view identify anatomical...
The Coronavirus disease (COVID-19) pandemic is causing millions of infections and hundreds thousands deaths worldwide. Cumulative clinical laboratory evidence suggest that a subset patients with severe COVID-19 may develop cytokine storm syndrome during the course disease, respiratory impairment requiring ventilatory support. One field research nowadays to identify treat viral-induced hyperinflammation drugs used in other conditions characterized by an status. These might help reduce COVID19...
Background Hypovitaminosis D has been suggested to play a possible role in coronavirus disease 2019 (COVID-19) infection. Methods The aim of this study is analyze the relationship between vitamin status and biochemical panel inflammatory markers cohort patients with COVID-19. A secondary endpoint was evaluate correlation 25OHD levels severity disease. Ninety-three consecutive COVID-19-related pneumonia were evaluated from March May 2020 two hospital units Pisa, whom markers, levels, P/F...
Background. In Italy, 20 min of continuous, flat-line electrocardiogram are required for death declaration. Despite prolonged warm ischemia time, Italian centers reported good outcomes in controlled donation after circulatory (cDCD) liver transplantation by combining normothermic regional and end-ischemic machine perfusion (MP). The aim this study was to evaluate the safety feasibility use septuagenarian octogenarian cDCD donors with approach. Methods. All older than 70 y were evaluated...
Transient reduction in coronary perfusion pressure the isolated mouse heart increases microvascular resistance (paradoxical vasoconstriction) by an endothelium-mediated mechanism. To assess presence and extent of paradoxical vasoconstriction hearts from normal diabetic rats to determine whether increased heme oxygenase (HO)-1 expression HO activity, using cobalt protoporphyrin (CoPP), attenuates response, male Wistar were rendered with nicotinamide/streptozotocin for 2 wk either CoPP or...
Since early after the introduction of serum gamma-glutamyltransferase (GGT) in clinical practice as a reliable and widely employed laboratory test, epidemiological prospective studies have repeatedly shown that this activity possesses prognostic value for morbidity mortality. The association is independent possibly concomitant conditions liver disease, notably, significant correlation GGT exists with occurrence cardiovascular diseases (myocardial infarction, stroke). Experimental work has...
ABSTRACT Background The management of multiple myeloma is challenging because the disease incurable and unexpected relapses can threaten a patient's survival. Several assessment systems are currently available, but they often require invasive or costly procedures (e.g., instrumental bone marrow whole‐body examinations) rely on non‐specific markers in blood urine that may not be sufficient to assess monitor disease. Aims To address some these limitations, aim this study was evaluate potential...
Background: The use of the so-called extended criteria donors increases number grafts available for transplantation. Many studies reported their good outcomes but is debated due to increased risk complications. Ex situ liver perfusion has reduced graft discard rate and helped test function before implantation. Cytokines are known be involved in ischemia reperfusion injury potential predict during normothermic machine (NMP) not been fully investigated. aim this study was compare cytokines...