A5040109530- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Polyomavirus and related diseases
- Intestinal and Peritoneal Adhesions
- Appendicitis Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Historical and Architectural Studies
- Pituitary Gland Disorders and Treatments
- Myasthenia Gravis and Thymoma
- Hepatitis C virus research
- Transplantation: Methods and Outcomes
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
University of Pisa
2017-2024
Scuola Superiore Sant'Anna
2024
Azienda Ospedaliera Universitaria Pisana
2024
Ex situ normothermic machine perfusion (NMP) might minimize ischemia/reperfusion injury (IRI) of liver grafts. In this study, 20 primary transplantation recipients older grafts (≥70 years) were randomized 1:1 to NMP or cold storage (CS) groups. The study endpoint was evaluate graft and patient survival at 6 months posttransplantation. secondary bile duct biopsies; IRI by means peak transaminases within 7 days after surgery; incidence biliary complications month 6. Liver biopsies collected...
In Italy, 20 minutes of a continuous flat line on an electrocardiogram are required for declaration death. the setting donation after circulatory death (DCD), prolonged warm ischemia time prompted introduction abdominal normothermic regional perfusion (NRP) followed by postprocurement ex situ machine (MP). This is retrospective review DCD liver transplantations (LTs) performed at 2 centers using sequential NRP and MP. From January 2018 to April 2019, 34 donors were evaluated. Three (8.8%)...
To evaluate the use of elderly donors in liver transplantation (LT) and identify risk factors associated with a worse outcome.Use livers from very old could expand donor pool but is not universally implemented.This retrospective, single-center medical record review. From January 2001 to December 2014, 1354 LTs were performed. After exclusion <18 years, ABO-incompatible LT, re-LT UNOS 1 status patients, LT recipients stratified into 2 groups based on age: 18-69 (n=692) vs. ≥70 years (n=515)...
The use of machine perfusion (MP) in liver transplantation (LT) is spreading worldwide. However, its efficacy has not been demonstrated, and proper clinical far to go be widely implemented. Società Italiana Trapianti d'Organo (SITO) promoted the development an evidence-based position paper. A 3-step approach adopted develop this First, SITO appointed a chair cochair who then assembled working group with specific experience MP LT. Guideline Development Group framed questions into patient,...
Although livers from older donors (> 70 y) have been shown to be increasingly more efficiently used for transplant, donor comorbidities are considered additional risk factors. This is quite intriguing as known increase with advancing age in the population.We assessed whether and influenced liver procurement over a 15-year period cohort of 1702 brain-dead Tuscany, Italy.Over study period, potential significantly increased (P = .02) well proportion patients who were > 55 years old. The...