A5088909032- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal Transplantation Outcomes and Treatments
- COVID-19 Clinical Research Studies
- Pancreatic and Hepatic Oncology Research
- Long-Term Effects of COVID-19
- Renal and Vascular Pathologies
- Congenital Anomalies and Fetal Surgery
- Gallbladder and Bile Duct Disorders
- Abdominal vascular conditions and treatments
- SARS-CoV-2 and COVID-19 Research
- Renal cell carcinoma treatment
- Mechanical Circulatory Support Devices
- Diversity and Career in Medicine
- Hepatitis B Virus Studies
- Pancreatitis Pathology and Treatment
- Cancer, Lipids, and Metabolism
- Genetic and Kidney Cyst Diseases
- COVID-19 Impact on Reproduction
- Takotsubo Cardiomyopathy and Associated Phenomena
University of Padua
2022-2024
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2014-2024
Azienda Socio Sanitaria Territoriale Lariana
2018-2024
Ospedale Maggiore
2017-2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2019-2024
Collaborative Group (United States)
2024
University of Milano-Bicocca
2016-2023
Società Italiana di Reumatologia
2021
University of Pavia
2016-2020
Creative Research Enterprises (United States)
2017
Liver graft utilization rates are a hot topic due to the worldwide organ shortage and increasing number of transplant candidates on waiting lists. perfusion techniques have been introduced in several countries, may help increase supply, as they potentially enable assessment livers before use.Liver offers were counted from donation after circulatory death (DCD) donors (Maastricht type III) arising during past decade eight including Belgium, France, Italy, Netherlands, Spain, Switzerland, UK,...
The role of donation after cardiac death (DCD) in expanding the donor pool is mainly limited by incidence primary nonfunction (PNF) and ischemia-related complications. Even greater concern exists toward uncontrolled DCD, which represents largest potential DCD donors. We recently started first Italian series liver transplantation, using normothermic regional perfusion (NRP) 6 donors 1 controlled case to deal with legally required no-touch period 20 minutes. examined our 7 cases for PNF, early...
Donation after circulatory death (DCD) in Italy, given its 20-min stand-off period, provides a unique bench test for normothermic regional perfusion (NRP) and dual hypothermic oxygenated machine (D-HOPE).We coordinated multicenter retrospective Italian cohort study with 44 controlled DCD donors, who underwent NRP, to present transplant characteristics results. To rank our results according the high donor risk, we matched compared subgroup of 37 livers, preserved NRP D-HOPE, static-preserved...
COVID-19 pandemic dramatically impacted transplantation landscape. Scientific societies recommend against the use of donors with active SARS-CoV-2 infection. Italian Transplant Authority recommended to test recipients/donors for SARS-CoV-2-RNA immediately before liver transplant (LT) and, starting from November 2020, grafts deceased infection were allowed be considered urgent-need candidates active/resolved COVID-19. We present results first 10 LTs within an multicenter series. Only two...
Despite strong evidence for improved preservation of donor livers by machine perfusion, longer post-transplant follow-up data are urgently needed in an unselected patient population. We aimed to assess long-term outcomes after transplantation hypothermic oxygenated perfusion (HOPE)-treated based on real-world (i.e., IDEAL-D stage 4). In this international, multicentre, observational cohort study, we collected from adult recipients HOPE-treated transplanted between January 2012 and December...
Donation after circulatory death (DCD) in Italy constitutes a relatively unique population because of the requirement no-touch period 20 minutes. The first aim this study was to compare liver transplantations from donors who were maintained on normothermic regional perfusion and suffered extended warm ischemia (DCD group, n = 20) with those extracorporeal membrane oxygenation (ECMO) succumbed brain (ECMO 17) standard (donation [DBD] 52). Second, we conducted an explorative analysis DCD group...
End-ischemic viability testing by normothermic machine perfusion (NMP) represents an effective strategy to recover liver grafts having initially been discarded for transplantation (LT). However, its results in the setting of significant (≥30%) macrovesicular steatosis (MaS) have not specifically assessed. Prospectively maintained databases at two high-volume LT centers Northern Italy were searched identify cases end-ischemic NMP performed test livers with MaS ≥ 30% period from January 2019...
Background. Split liver transplantation is a valuable means of mitigating organ scarcity but requires significant surgical and logistical effort. Ex vivo splitting associated with prolonged cold ischemia, potentially negative effects on viability. Machine perfusion can mitigate the ischemia–reperfusion injury by restoring cellular energy improving outcomes. Methods. We describe novel technique full-left/full-right splitting, reconstruction vena cava middle hepatic vein, dual arterial portal...
The use of machine perfusion (MP) in liver transplantation (LT) is spreading worldwide. However, its efficacy has not been demonstrated, and proper clinical far to go be widely implemented. Società Italiana Trapianti d'Organo (SITO) promoted the development an evidence-based position paper. A 3-step approach adopted develop this First, SITO appointed a chair cochair who then assembled working group with specific experience MP LT. Guideline Development Group framed questions into patient,...
: The latest Liver Imaging Reporting and Data System (LI-RADS) classification by the American College of Radiology has been recently endorsed in Association for Study Disease (AASLD) guidelines Hepatocellular carcinoma (HCC) management. Although LI-RADS protocol developed as a diagnostic algorithm, there is some evidence concerning possible correlation between different classes specific pathological features HCC. We aimed to investigate such radiological/pathological prognostic implication...
Early-stage hepatocellular carcinoma could benefit from upfront liver resection (LR) or transplantation (LT), but the optimal strategy in terms of tumor-related outcomes is still debated. We compared oncological LR and LT for carcinoma, stratifying study population into a low-, intermediate-, high-risk class according to risk death at 5-y predicted by previously developed prognostic model. The impact tumor pathology on low- intermediate-risk patients undergoing was investigated as secondary...
Although laparoscopic donor nephrectomy (LDN) represents the gold-standard technique for kidney living donation, robotic (RDN) settled as another appealing minimally invasive over past decades. A comparison between LDN and RDN outcomes was performed.RDN were compared, focusing on operative time perioperative risk factors affecting surgery duration. Learning curves both techniques compared through spline regression cumulative sum models.The study analyzed 512 procedures (154 358 procedures)...