A5015161750- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Cytomegalovirus and herpesvirus research
- Hepatitis Viruses Studies and Epidemiology
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Lymphocytic Leukemia Research
- COVID-19 and healthcare impacts
- Mycobacterium research and diagnosis
- Viral Infections and Immunology Research
- Infectious Diseases and Tuberculosis
- Liver Diseases and Immunity
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2001-2023
IRCCS San Camillo Hospital
2021-2022
Center for Prevention and Treatment of Infections
2021
Weatherford College
2020
Consortium for Research in Automatic and Telecommunications
2015
Istituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro
2014
Institutul Clinic Fundeni
2013
Clinical Research Management
2005
Karolinska Institutet
1996-2000
Objective: Although highly active antiretroviral therapy (HAART) can reverse HIV-related neurocognitive impairment (NCI), neuropsychologic (NP) deficits may persist in a substantial proportion of patients despite treatment. We assessed the prevalence and predictors persistent NP long-term HAART with NCI. Methods: A group 94 NCI underwent 2 to 7 serial batteries, neurologic examination, brain imaging studies. Patients received for mean 63 (range: 6-127) months. According assessment results,...
COVID-19 pandemic dramatically impacted transplantation landscape. Scientific societies recommend against the use of donors with active SARS-CoV-2 infection. Italian Transplant Authority recommended to test recipients/donors for SARS-CoV-2-RNA immediately before liver transplant (LT) and, starting from November 2020, grafts deceased infection were allowed be considered urgent-need candidates active/resolved COVID-19. We present results first 10 LTs within an multicenter series. Only two...
Objective: To evaluate the effect of drug class-wide resistance (CWR) on survival in HIV-infected individuals who underwent genotypic test after antiretroviral failure. Design: Observational, longitudinal cohort study. Methods: experiencing treatment failure were enrolled at first test. End-points death for any cause, AIDS-related and AIDS-defining event/death. CWR was defined according to International AIDS Society consensus. Survival analysis performed with Cox's model. Results: Among 623...
Limited data are available on risks and benefits of anti-SARS-CoV2 vaccination in solid organ transplant recipients, weaker responses have been described. At the Italian National Institute for Infectious Diseases, 61 liver recipients underwent testing to describe dynamics humoral cell-mediated immune response after two doses mRNA vaccines compared with 51 healthy controls. Humoral was measured by quantifying both anti-spike neutralizing antibodies; PBMC proliferation assay IFN-γ IL-2...
Objective To study the appearance of drug-induced mutations at low viraemia in treated HIV-1-infected patients. Design and methods Fourteen patients, who received their first (n = 5), second 7) or third 2) line antiretroviral combination therapy, developed a persistent low-grade after an initial decrease viral load (VL) to less than 500 copies/ml. The amount HIV-1 RNA 71) reverse transcriptase (RT)/protease sequences 56) were determined longitudinally obtained plasma samples during mean...
Before the introduction of HAART, HIV-associated neurocognitive impairment (NCI) was recognized as an independent risk factor for death. Since 1996, we conducted a prospective study to assess whether NCI still represents negative prognostic mortality. Patients were administered measures function (a battery 17 neuropsychological tests), clinical and neurological evaluation, laboratory testing, brain imaging studies. Among 412 enrolled patients, 224 (54.4%) neurocognitively impaired 188...
Abstract The sinusoidal endothelial cells present in the liver (LSECs) are tipically characterized by presence of pores (fenestrae). During some pathological conditions LSECs undergo “capillarization”, a process loss fenestrations and acquisition vascular phenotype. In chronic disease capillarization has been reported to precede development fibrosis. modification setting HCV infection is currently poorly investigated. Considering that accounts for important changes hepatocytes view intimate...
Objectives: To investigate gp41 variability and correlation with viro-immunological parameters in 54 HIV-1-infected patients receiving enfuvirtide added as single active drug to a failing regimen. Methods: One hundred two HIV-1 sequences clinical follow-up from enfuvirtide-treated were analysed baseline week 36 of treatment. The association mutations viraemia/CD4 count was assessed by Mann–Whitney test. Results: addition the regimen induced at 4 viraemia decrease 5.1 4.3 log10/mL (P =...
In many industrialized countries HCV infection is characterized by an increasing prevalence during ageing; however, data on the efficacy of treatment among older patients are scarce. This study was set up to evaluate effect age chronic hepatitis with peginterferon alpha plus ribavirin.We retrospectively reviewed medical records 153 adult treated combination therapy; 30 them (19.6%) were 65 years or older.In multivariable analysis, groups >/=40 had similar odds achieving sustained virologic...
Yttrium-90 microspheres radioembolization (Y90-RE) has shown to be an effective and safe treatment of primary liver tumors. According the staging system Barcelona Clinic Liver Cancer (BCLC), patients with macrovascular invasion are staged as BCLC-C. This paper comprises a presentation results following application procedure.From January 2002 December 2015, 367 were transplanted at San Camillo Hospital Center. One hundred forty-three for hepatocellular carcinoma (HCC) in 22 cases treated...
Liver injury in COVID-19 patients has progressively emerged, even those without a history of liver disease, yet the mechanism pathogenicity is still controversial. frequently associated with increased serum ferritin levels, and hyperferritinemia was shown to correlate illness severity. The major site for iron storage, conditions overload have been established pathogenic role development diseases. We presented here six who developed severe COVID-19, biochemical evidence failure. Three cases...
We describe the preliminary results of bulevirtide compassionate use in patients with hepatitis B and delta virus (HBV/HDV)-related cirrhosis clinically significant portal hypertension, including those living HIV.We conducted a prospective observational study consecutive patients. Clinical evaluation, liver function tests, bile acid levels, HDV-RNA, HBV-DNA, surface antigen, spleen stiffness were assessed at baseline after treatment months 1, 2, 3, 4, 6, 9, 12. HIV-RNA CD4+/CD8+ count people...
Background. Human immunodeficiency virus type 1 (HIV-1) gp41 is a crucial determinant for HIV-1 pathogenicity. We investigated the correlation of enfuvirtide (ENF)-associated mutational clusters with viroimmunological parameters, as well potential underlying mechanisms. Methods. A total 172 sequences and clinical follow-up data from 73 ENF-treated patients were analyzed monthly, baseline to week 48. Results. There 7 novel mutations positively associated ENF treatment correlated classic...
In 2012, an Italian Named Patient Program began for hepatitis C virus (HCV)-infected liver transplant (LT) recipients with advanced fibrosis, before approval of direct antiviral agents (DAA), to benefit severely ill patients. The aim this "real-life" study was assess treatment efficacy and safety extended course daclatasvir (DCV) plus sofosbuvir (SOF) or without ribavirin (RBV).All HCV LT severe fibrosis in 15 centers were treated DCV+SOF±RBV 24 weeks; sustained virological response assessed...
AbstractA case-control study was performed on 9,175 Italian adult outpatients in 5 hospitals Rome. The carried out to clarify the role of some less investigated risk factors (RF) spread hepatitis C virus (HCV) infection. All subjects were contacted by interviewers, who completed a questionnaire. Their sera stored and subsequently tested for both HCV B core (HBc) antibodies. 365 subjects, positive anti-HCV anti-HBc-negative, had denied intravenous drug use (IDU) (cases) compared with an equal...
An HIV positive male from Brazil, living in Italy since 1989, developed a single non-itching, papulo-erythematous infiltrative lesion on the face after 2 months beginning of HAART. A diagnosis leprosy was made, suggesting that immunodeficiency masked disease, until skin manifestation became evident with immune-recovery.
In chronic HCV infection, treatment failure and defective host immune response highly demand improved therapy strategies. Vγ9Vδ2 T-cells may inhibit replication in vitro through IFN-γ release after Phosphoantigen (PhAg) stimulation. The aim of our work was to analyze T-cell functionality during studying the role IFN-α on their function capability. production by analyzed 24 HCV-infected patients 35 healthy donors (HD) PhAg stimulation with or without IFN-α. effect vivo PhAg/IFN-α...
In recent years, increasing numbers of patients infected with HIV-1 non-B subtypes have been treated modern antiretroviral regimens. Therefore, a better knowledge HIV drug resistance in strains is crucial. Thus, we compared the mutational pathways involved among most common Italy (F, C, and CRF02_AG) B subtype. total, 2234 pol sequences from 1231 virologically failing Central were analyzed. The prevalence mutations protease reverse transcriptase between has evaluated. Among...