A5085176425- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Cytomegalovirus and herpesvirus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Organ Donation and Transplantation
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Congenital Anomalies and Fetal Surgery
- Systemic Lupus Erythematosus Research
- Transplantation: Methods and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
- Antibiotics Pharmacokinetics and Efficacy
- Immunodeficiency and Autoimmune Disorders
- Renal and Vascular Pathologies
- Gallbladder and Bile Duct Disorders
- Metabolism and Genetic Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Antifungal resistance and susceptibility
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2023-2025
University of Bari Aldo Moro
2007-2025
University of Turin
2015-2024
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2015-2024
University of Calabria
2024
Fondazione Ricerca Molinette
2014-2022
May Institute
2022
Medical University of Vienna
2016
University Hospital Frankfurt
2016
Goethe University Frankfurt
2016
Abstract Hypothermic oxygenated machine perfusion (HOPE) was introduced in liver transplantation (LT) to mitigate ischemia-reperfusion injury. Available clinical data mainly concern LT with donors after circulatory-determined death, whereas on brain-dead (DBD) are scarce. To assess the impact of end-ischemic HOPE DBD LT, primary adult LTs performed between March 2016 and June 2018 were analyzed. used selected cases donor age >80 years, apparent severe graft steatosis, or ischemia time ≥10...
COVID-19 pandemic dramatically impacted transplantation landscape. Scientific societies recommend against the use of donors with active SARS-CoV-2 infection. Italian Transplant Authority recommended to test recipients/donors for SARS-CoV-2-RNA immediately before liver transplant (LT) and, starting from November 2020, grafts deceased infection were allowed be considered urgent-need candidates active/resolved COVID-19. We present results first 10 LTs within an multicenter series. Only two...
Prompted by the utilization of extended criteria donors, dual hypothermic oxygenated machine perfusion (D-HOPE) was introduced in liver transplantation to improve preservation. When donors after neurological determination death (DBD) are used, D-HOPE effect on graft outcomes is unclear. To assess value this setting and identify ideal scenarios for its use, data primary adult transplant recipients from January 2014 April 2021 were analyzed using inverse probability treatment weighting,...
Abstract More liver transplants (LT) are performed worldwide thanks to extended criteria donors (ECD). This is paralleled by a supposed increased risk of allograft failure (AF) at 90 and 365 days. study has been designed portray the LT practice investigate models AF prediction impact mitigation strategies for further improving graft patient outcomes. multicenter, international, non-competitive, observational two segment on consecutive LTs over periods (2017–2019 2022–2024). A steering...
End-ischemic viability testing by normothermic machine perfusion (NMP) represents an effective strategy to recover liver grafts having initially been discarded for transplantation (LT). However, its results in the setting of significant (≥30%) macrovesicular steatosis (MaS) have not specifically assessed. Prospectively maintained databases at two high-volume LT centers Northern Italy were searched identify cases end-ischemic NMP performed test livers with MaS ≥ 30% period from January 2019...
Abstract Background Surgical resection remains the treatment of choice for primary and secondary liver cancer. Complications are mainly related to blood loss. Radiofrequency-assisted (RF-R) has been proposed parenchymal division as an alternative clamp crushing in order reduce Methods Fifty patients (median age 62 (range 30–82) years) undergoing hepatectomy were randomized RF-R (24 patients) or clamp-crushing method (26). In group plane was precoagulated by multiple insertion a planar...
Abstract Background Patients colonized with carbapenem-resistant Enterobacteriaceae (CRE) are at higher risk of developing CRE infection after liver transplantation (LT), associated high morbidity and mortality. Prediction model for LT among carriers could be useful to target preventive strategies. Methods Multinational multicenter cohort study consecutive adult patients underwent before or LT, from January 2010 December 2017. Risk factors were analyzed by univariate analysis Fine-Gray...
Abstract Background & Aims Several studies have shown that new direct‐acting antivirals maintain their efficacy in liver transplant ( LT ) recipients with severe hepatitis C virus HCV recurrence. We determined the clinical impact of sofosbuvir/ribavirin through changes function and fibrosis state at 24 48 weeks after treatment. Methods Between June 2014 July 2015, 126 patients (30 F3, 96 F4 Metavir stage) were enrolled to receive sofosbuvir + ribavirin (24 weeks, 118 patients) or...
International guidelines recommend the use of ultrasound as a surveillance tool for hepatocellular carcinoma (HCC) in patients with cirrhosis, while role serum biomarkers is still debated. We investigated alpha-fetoprotein (AFP), protein induced by vitamin K absence or antagonist II (PIVKA-II) and glypican-3 (GPC-3) diagnostic accuracy HCC detection prediction liver cirrhosis viral etiology under surveillance. A total 349 (200 149 HCC) were enrolled. The 200 consisted 114 HCC-free after 36...
Invasive fungal infection (IFI) is a severe complication of liver transplantation burdened by high mortality. Guidelines recommend targeted rather than universal antifungal prophylaxis based on tiers risk.We aimed to evaluate IFI incidence, risk factors, and outcome after implementation simplified two-tiered regimen single broad-spectrum drug (amphotericin B). Patients presenting 1 or more factors according literature were administered prophylaxis. Prospectively collected data all adult...
Covid-19 pandemic is deeply affecting transplant activity worldwide. It unclear whether solid organ recipients are at increased risk of developing severe complications and how they should be managed, also concerning immunosuppression. This a report about the course management SARS-CoV-2 infection in liver from single center Northwestern Italy period March-April 2020. Three patients who were treated our institution reported detail, whereas summary data provided for those managed peripheral...
Hepatitis D Virus (HDV) infection is vanishing in Italy. It therefore believed that hepatitis no longer a medical problem the domestic population of country but remains concern only migrants from HDV-endemic areas.To report clinical features and impact residual HDV infections Italy.From 2010 to 2019, one hundred ninety-three first-time patients with chronic liver disease attended gastroenterology units Torino San Giovanni Rotondo (Apulia); 121 were native Italians 72 immigrants born abroad....
Abstract Background Liver transplantation is the state-of-the-art curative treatment for end-stage liver disease. Imaging a key element in detection of postoperative complications. So far, limited data available regarding best radiologic approach to monitor children after transplantation. Objective To harmonize imaging pediatric transplantation, European Society Pediatric Radiology Abdominal Taskforce initiated survey addressing current status including pre-, intra-, and phases. This paper...
Background and aims: Besides the increased risk of perioperative morbidity, graft failure, mortality, majority PVT are diagnosed at liver transplantation (LT). Improving preoperative management patient selection may lead to better short-term long-term outcomes reduce a futile LT. The authors aimed identify predictors adverse after LT in patients with nonmalignant portal vein thrombosis (PVT) improve donor recipient matching by analyzing results Italian cohort recipients. Methods: Adult who...
BackgroundInternational consensus has recently introduced a new definition of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). We sought to analyse epidemiological trends, prognostic features, and transplant survival benefits MASLD non-MASLD patients waiting for liver transplantation (LT) in Italy.Materials methodsUtilising the Italian Transplant Registry database, we analysed data from adult listed primary LT due end-stage chronic disease between January 2012 December 2022....
: Basiliximab (B), an anti-CD25 monoclonal antibody, may represent alternative to steroids (S) in immunosuppression after liver transplantation (LTx). The aim of this prospective randomized clinical trial was compare B with S a cyclosporin A (CsA)-based regimen primary LTx.: Forty-seven adult recipients LTx were randomly assigned receive or S. CsA administered at the initial dose 10 mg/kg/day and adjusted target C2 level 800 1000 ng/mL by day 7. Clinically suspected acute cellular rejection...
Abstract As graft survival in pediatric LT is often affected by progressive fibrosis, numerous centers carry out protocol liver biopsies. Follow‐up biopsy protocols differ from center to center, but all biopsies are progressively spaced out, as time transplant increases. Therefore, there a need for non‐invasive techniques evaluate fibrosis progression those children who have no clinical or serological signs of damage. Indirect markers, such the APRI , should be relied on with caution because...
Abstract Previous studies have shown that human liver stem-like cells (HLSCs) may undergo differentiation in vitro into urea producing hepatocytes and vivo sustain function models of experimentally induced acute injury. The aim this study was to assess the safety HLSCs intrahepatic administration inherited neonatal-onset hyperammonemia. approved by Agenzia Italiana del Farmaco on favorable opinion Italian Institute Health as an open-label, prospective, uncontrolled, monocentric Phase I (HLSC...
Subcutaneous administration of hepatitis B immunoglobulin (HBIg) is effective in preventing virus (HBV) recurrence after liver transplantation, but early conversion to subcutaneous undocumented.In a prospective study, patients transplanted for terminal disease due HBV infection who were DNA-negative at transplant switched by week 3 posttransplantation from intravenous HBIg (500 or 1000 IU weekly fortnightly, adjusted according serum anti-HBs trough level) if they HBsAg- and HBV-DNA negative...
Background: Machine perfusion may be able to mitigate ischemia-reperfusion injury (IRI), which increases hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). This study aimed investigate the impact of dual-hypothermic oxygenated machine (D-HOPE) on HCC in LT. Methods: A single-center retrospective was conducted from 2016 2020. Pre- and postoperative data patients undergoing LT were analyzed. Recipients a D-HOPE-treated graft compared those livers preserved using static...
Patients with HDV/HBV-related end-stage liver disease candidates for transplantation(LT) have traditionally been regarded as a special population, although their outcomes are controversial. A intention-to-treat(ITT) analysis of long-term HDV/HBV-coinfected patients waitlisted LT in Italy, between 2011-2020, was performed and compared to HBV-monoinfected candidates. Out 1,731 HBV-infected candidates, 1,237(71.5%) had HBV-monoinfection 494(28.5%) HDV/HBV-coinfection. At listing, were...
Keratin 19 (K19) is a cancer stem cell marker expressed by subpopulation of hepatocellular carcinoma (HCC), associated with tumor aggressiveness. We evaluated the prognostic value serum K19 fragment (CYFRA 21-1), in comparison or combination alpha-fetoprotein (AFP) and protein induced vitamin-K absence antagonist-II (PIVKA-II), patients HCC. A total 160 (28F/132M; median age 62, range 44–86 years) new diagnosis HCC available samples collected at were analyzed retrospectively. Median overall...
Tacrolimus (TAC, FK-506) and everolimus (EVE, RAD001) are immunosuppressors used to treat pediatric patients undergoing liver transplantation. Their hematic TDM by liquid chromatography became standard practice. However, it does not always reflect concentrations at their active site. Our aim was develop validate a new method for the simultaneous TAC EVE quantification into target cells: peripheral blood mononuclear cells (PBMCs). Peripheral were collected using cell preparation tubes; number...