Alberto Zanella
A5025253171- Erythrocyte Function and Pathophysiology
- Respiratory Support and Mechanisms
- Blood groups and transfusion
- Mechanical Circulatory Support Devices
- Neonatal Health and Biochemistry
- Hemoglobinopathies and Related Disorders
- Cardiac Arrest and Resuscitation
- Transplantation: Methods and Outcomes
- Blood properties and coagulation
- COVID-19 Clinical Research Studies
- Blood disorders and treatments
- Organ Transplantation Techniques and Outcomes
- Nosocomial Infections in ICU
- Pancreatic function and diabetes
- Hepatitis C virus research
- Immunodeficiency and Autoimmune Disorders
- Intensive Care Unit Cognitive Disorders
- Hepatitis B Virus Studies
- Airway Management and Intubation Techniques
- Complement system in diseases
- Renal function and acid-base balance
- Platelet Disorders and Treatments
- COVID-19 and healthcare impacts
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2015-2024
University of Milan
2015-2024
University of Sheffield
2024
University of Milano-Bicocca
2008-2023
AIDS Clinical Trials Group
2023
Academy of Emergency Medicine and Care
2023
Institució Catalana de Recerca i Estudis Avançats
2023
Ospedale Maggiore
2011-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2004-2022
Institute of Photonic Sciences
2022
In December 2019, a novel coronavirus (severe acute respiratory syndrome 2 [SARS-CoV-2]) emerged in China and has spread globally, creating pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited.To characterize with disease 2019 (COVID-19) requiring treatment an unit (ICU) Lombardy region Italy.Retrospective case series 1591 consecutive laboratory-confirmed COVID-19 referred for ICU admission to coordinator center (Fondazione IRCCS...
There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes 2019 (Covid-19). Genomewide association analysis may allow for identification of potential genetic factors involved development Covid-19.
<h3>Importance</h3> Many patients with coronavirus disease 2019 (COVID-19) are critically ill and require care in the intensive unit (ICU). <h3>Objective</h3> To evaluate independent risk factors associated mortality of COVID-19 requiring treatment ICUs Lombardy region Italy. <h3>Design, Setting, Participants</h3> This retrospective, observational cohort study included 3988 consecutive laboratory-confirmed referred for ICU admission to coordinating center (Fondazione IRCCS [Istituto di...
Background: Serum alanine aminotransferase (ALT) activity, the variable most commonly measured to assess hepatic disease, fails identify many patients with injury. Current standards for "normal" ALT level were defined by using populations that included persons subclinical liver disease. Objective: To update definitions of healthy ranges serum level. Design: Retrospective cohort study. Setting: A university hospital in Milan, Italy. Participants: 6835 who first-time blood donors from 1995...
Objectives: Severe cases of coronavirus disease 2019 develop the acute respiratory distress syndrome, requiring admission to ICU. This study aimed describe specific pathophysiological characteristics syndrome from 2019. Design: Prospective crossover physiologic study. Setting: ICU a university-affiliated hospital northern Italy dedicated care patients with confirmed diagnosis Patients: Ten intubated and Interventions: We performed two-step positive end-expiratory pressure trial change 10 cm...
The erythrocyte cytoplasmic proteome is composed of 98% hemoglobin; the remaining 2% largely unexplored. Here we used a combinatorial library hexameric peptides as capturing agent to lower signal hemoglobin and amplify low very abundance proteins in cytoplasm human red blood cells (RBCs). Two types hexapeptide beads have been adopted: amino-terminal which further derivatized by carboxylation. amplification suppression high species were fully demonstrated two-dimensional gel maps nano-LC-MSMS...
During acute lung injury (ALI), mechanical ventilation can aggravate inflammation by promoting alveolar distension and cyclic recruitment-derecruitment. As an estimate of the intensity inflammation, metabolic activity be measured positron emission tomography imaging [(18)F]fluoro-2-deoxy-D-glucose.To assess relationship between gas volume changes induced tidal pulmonary in patients with ALI.In 13 mechanically ventilated ALI relatively high positive end-expiratory pressure, we performed a...
Congenital dyserythropoietic anemia type II (CDAII) is an autosomal recessive disease characterized by ineffective erythropoiesis, hemolysis, erythroblast morphological abnormalities, and hypoglycosylation of some red blood cell (RBC) membrane proteins. Recent studies indicated that CDAII caused a defect disturbing Golgi processing in erythroblasts. A linkage analysis located candidate region on chromosome 20, termed the CDAN2 locus, majority patients but aberrant gene has not so far been...
Hereditary spherocytosis (HS), hereditary elliptocytosis (HE), and stomatocytosis (HSt) are inherited red cell disorders caused by defects in various membrane proteins. The heterogeneous clinical presentation, biochemical genetic abnormalities HS HE have been well documented. need to raise the awareness of HSt, albeit its much lower prevalence than HS, is due undesirable outcome splenectomy these patients.The scope this guideline identify characteristic features, parameters (including...
Rationale: Hyperlactatemia in sepsis may derive from a prevalent impairment of oxygen supply/demand and/or use. Discriminating between these two mechanisms be relevant for the early fluid resuscitation strategy.Objectives: To understand relationship among central venous saturation (ScvO2), lactate, and base excess to better determine origin lactate.Methods: This was post hoc analysis baseline variables 1,741 patients with enrolled multicenter trial ALBIOS (Albumin Italian Outcome Sepsis)....