Ferdinando Luca Lorini
A5046599768- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 and healthcare impacts
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- SARS-CoV-2 and COVID-19 Research
- Hemodynamic Monitoring and Therapy
- Nausea and vomiting management
- Pain Management and Opioid Use
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Ultrasound in Clinical Applications
- Sepsis Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Pulmonary Hypertension Research and Treatments
- Thermal Regulation in Medicine
- Heart Failure Treatment and Management
Ospedale Papa Giovanni XXIII
2016-2025
University of Milano-Bicocca
2022-2024
University of Bergamo
1997-2022
Azienda Ospedaliero Universitaria Ospedali Riuniti
2003-2022
University of Salerno
2022
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2020
Barro Colorado Island
2020
National Institutes of Health
2017
Centro Studi GISED
2015
Ospedale Maggiore
2015
In December 2019, a novel coronavirus (severe acute respiratory syndrome 2 [SARS-CoV-2]) emerged in China and has spread globally, creating pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited.To characterize with disease 2019 (COVID-19) requiring treatment an unit (ICU) Lombardy region Italy.Retrospective case series 1591 consecutive laboratory-confirmed COVID-19 referred for ICU admission to coordinator center (Fondazione IRCCS...
<h3>Importance</h3> Many patients with coronavirus disease 2019 (COVID-19) are critically ill and require care in the intensive unit (ICU). <h3>Objective</h3> To evaluate independent risk factors associated mortality of COVID-19 requiring treatment ICUs Lombardy region Italy. <h3>Design, Setting, Participants</h3> This retrospective, observational cohort study included 3988 consecutive laboratory-confirmed referred for ICU admission to coordinating center (Fondazione IRCCS [Istituto di...
Abstract Background Severe COVID-19 is characterised by interstitial pneumonia and hyperinflammation, with elevated levels of pro-inflammatory cytokines, such as IL-6. Effective treatments are urgently needed, IL-6 a rational target to reduce hyperinflammation. Methods An observational, control cohort, single-centre study initiated at the Papa Giovanni XXIII Hospital in Bergamo, Italy included patients confirmed nasopharyngeal swab positive for severe acute respiratory syndrome coronavirus 2...
Rationale: Treatment with noninvasive ventilation (NIV) in coronavirus disease (COVID-19) is frequent. Shortage of intensive care unit (ICU) beds led clinicians to deliver NIV also outside ICUs. Data about the use COVID-19 limited.Objectives: To describe prevalence and clinical characteristics patients treated investigate factors associated failure (need for intubation or death).Methods: In this prospective, single-day observational study, we enrolled adult who were ICU from 31 hospitals...
Optimal perioperative antiplatelet therapy in patients with coronary stents undergoing surgery still remains poorly defined and a matter of debate among cardiologists, surgeons anaesthesiologists. Surgery represents one the most common reasons for premature discontinuation, which is associated significant increase mortality major adverse cardiac events, particular stent thrombosis. Clinical practice guidelines provide little support regard to managing phase case non-deferrable surgical...
Adaptations and Lessons in the Province of Bergamo A referral hospital hardest-hit region Italy had to manage a continuously increasing number daily admissions for Covid-19 after delay...
Abstract Objectives To evaluate the inter-rater agreement of chest X-ray (CXR) findings in coronavirus disease 2019 (COVID-19) and to determine value initial CXR along with demographic, clinical, laboratory data at emergency department (ED) presentation for predicting mortality need ventilatory support. Methods A total 340 COVID-19 patients who underwent ED setting (March 1–13, 2020) were retrospectively included. Two reviewers independently assessed abnormalities, including ground-glass...
Gender-related factors might affect vulnerability to Covid-19. The aim of this study was describe the role gender on clinical features and 28-day mortality in Covid-19 patients.
The introduction of synthetic opioids in clinical practice played a major role the history anesthesiology. For years, anesthesiologists have been thinking that are needed for intraoperative anesthesia. However, we now know (especially short-acting molecules) definitely not ideal analgesics and may even be counterproductive, increasing postoperative pain. As well, revealed important drawbacks associated to poor perioperative outcomes. matter fact, efforts pain management last 30 years were...
Hypothesizing that the non-aerated lung fraction as evaluated by quantitative analysis of computed tomography (CT) equals shunt (V A /Q = 0), we used a computational approach to estimate magnitude ventilation–perfusion mismatch in severe COVID-19. The results show hyperperfusion poorly ventilated region is likely cause hypoxemia observed. extensive microthrombosis pulmonary circulation may represent pathophysiological mechanism such V distribution.
Importance Data on the association of COVID-19 vaccination with intensive care unit (ICU) admission and outcomes patients SARS-CoV-2–related pneumonia are scarce. Objective To evaluate whether is associated preventing ICU for to compare baseline characteristics vaccinated unvaccinated admitted an ICU. Design, Setting, Participants This retrospective cohort study regional data sets reports: (1) daily number administered vaccines (2) all consecutive in Lombardy, Italy, from August 1 December...
The COVID-19 pandemic has affected millions worldwide, causing mortality and multi-organ morbidity. Neurological complications have been recognized. This study aimed to assess brain structural, microstructural, connectivity alterations in patients with COVID-19-related olfactory or cognitive impairment using post-acute (time from onset: 264[208-313] days) multi-directional diffusion-weighted MRI (DW-MRI).
Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented. Methods: We examined the disease progression of COVID-19 in 6,914 patients admitted hospitals Europe and China. In addition, we evaluated progress symptoms 37,187 individuals reporting into COVID Symptom Study application. Findings: Meta-analysis mortality risk seven European estimated odds ratios per 1-day increase admission date 0.981 (0.973–0.988, p &lt; 0.001)...
Background.Findings from February, 2020, indicate that the clinical spectrum of Covid-19 can be heterogeneous, probably due to infectious dose and viral load SARS-CoV-2 within first weeks outbreak.The aim this study was investigate predictors overall 28-day mortality at peak Italian outbreak.Methods.Retrospective observational all patients admitted main hospital Bergamo, February 23 March, 14, 2020.Results.508 were hospitalized , predominantly male (72.4%), mean age 66±15 years; 49.2% older...
Abstract Background Extracorporeal membrane oxygenation (ECMO) has become an established rescue therapy for severe acute respiratory distress syndrome (ARDS) in several etiologies including influenza A H1N1 pneumonia. The benefit of receiving ECMO coronavirus disease 2019 (COVID-19) is still uncertain. aim this analysis was to compare the outcome patients who received veno-venous COVID-19 and Influenza associated ARDS. Methods This a multicenter retrospective cohort study adults with ARDS,...
COVID-19 neurological manifestations have been progressively recognized. Among available MRI techniques, diffusion weighted imaging (DWI) shows promise to study microstructure, inflammation, and edema. Previous DWI studies reported alterations in brain diffusivity patients, as assessed by morphologic evaluation of scans only. The aim this was assess quantify patients with manifestations. 215 (olfactory and/or other disorders) 36 normal controls were compared studied T1-weighted scans....