Lorenzo Grazioli
A5088277199- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- COVID-19 and Mental Health
- Sepsis Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Thermal Regulation in Medicine
- Family and Patient Care in Intensive Care Units
- SARS-CoV-2 and COVID-19 Research
- Aortic aneurysm repair treatments
- Organ Transplantation Techniques and Outcomes
- COVID-19 and healthcare impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Cardiac Structural Anomalies and Repair
- Dermatological and COVID-19 studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Liver Disease and Transplantation
- Hereditary Neurological Disorders
- Congenital Diaphragmatic Hernia Studies
- Radiology practices and education
Ospedale Papa Giovanni XXIII
2018-2024
University of Bergamo
2021-2022
Ospedale regionale di Lugano
2021
Ente Ospedaliero Cantonale
2021
Prince Charles Hospital
2021
University Gastroenterology
2021
Baylor College of Medicine
2020
University Hospitals of Leicester NHS Trust
2019
Glenfield Hospital
2019
Azienda Ospedaliero Universitaria Ospedali Riuniti
2012
In December 2019, a novel coronavirus (severe acute respiratory syndrome 2 [SARS-CoV-2]) emerged in China and has spread globally, creating pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited.To characterize with disease 2019 (COVID-19) requiring treatment an unit (ICU) Lombardy region Italy.Retrospective case series 1591 consecutive laboratory-confirmed COVID-19 referred for ICU admission to coordinator center (Fondazione IRCCS...
Extracorporeal life support (ECLS) was developed more than 50 years ago, initially with venoarterial and subsequently venovenous configurations. As the technique of ECLS significantly improved newer skills developed, complexity in terminology advances cannula design led to some misunderstanding inconsistency definitions, both clinical practice scientific research. This document is a consensus multispecialty international representatives Life Support Organization, including North America,...
The Extracorporeal Life Support Organization (ELSO) Maastricht Treaty for Nomenclature in (ECLS) established consensus nomenclature and abbreviations ECLS to ensure accurate, concise communication. We build on this by layering a framework of precise efficient cannula configuration that describe flow direction, number cannulae used, any additional ECLS-related catheters, cannulation sites. This work is international representatives the ELSO, including those from North American, Latin...
There are limited data on the use of extracorporeal membrane oxygenation (ECMO) for pregnant and peripartum women with COVID-19 associated acute respiratory distress syndrome (ARDS). Pregnant may exhibit more severe infections COVID-19, requiring intensive care. We supported nine or ARDS ECMO, all surviving suffering no major complications from ECMO. Our case series demonstrates high-maternal survival rates ECMO support in management ARDS, highlighting that these postpartum patients should...
Importance Data on the association of COVID-19 vaccination with intensive care unit (ICU) admission and outcomes patients SARS-CoV-2–related pneumonia are scarce. Objective To evaluate whether is associated preventing ICU for to compare baseline characteristics vaccinated unvaccinated admitted an ICU. Design, Setting, Participants This retrospective cohort study regional data sets reports: (1) daily number administered vaccines (2) all consecutive in Lombardy, Italy, from August 1 December...
Background.Findings from February, 2020, indicate that the clinical spectrum of Covid-19 can be heterogeneous, probably due to infectious dose and viral load SARS-CoV-2 within first weeks outbreak.The aim this study was investigate predictors overall 28-day mortality at peak Italian outbreak.Methods.Retrospective observational all patients admitted main hospital Bergamo, February 23 March, 14, 2020.Results.508 were hospitalized , predominantly male (72.4%), mean age 66±15 years; 49.2% older...
Abstract Background Extracorporeal membrane oxygenation (ECMO) has become an established rescue therapy for severe acute respiratory distress syndrome (ARDS) in several etiologies including influenza A H1N1 pneumonia. The benefit of receiving ECMO coronavirus disease 2019 (COVID-19) is still uncertain. aim this analysis was to compare the outcome patients who received veno-venous COVID-19 and Influenza associated ARDS. Methods This a multicenter retrospective cohort study adults with ARDS,...
Abstract Background Heterogeneous respiratory system static compliance ( C RS ) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported previous small-case series or studies conducted at a national level. Methods We designed retrospective observational cohort study rapid data gathering from the international COVID-19 Critical Care Consortium to comprehensively describe —calculated as: tidal volume/[airway...
SARS-CoV-2 infection is associated with frequent thrombotic events, at the micro and macro-vascular level, due to perpetuation of a state hypercoagulability. The so-called 'COVID-19 coagulopathy' (CAC) represents key aspect in genesis organ damage from SARS-CoV-2. main coagulative alterations described literature are represented by high levels D-dimer fibrinogen. Although CAC has some common features disseminated intravascular coagulation sepsis-induced coagulopathy, there important...
Abstract Background The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate COVID-19 patients with moderate-to-severe ARDS the impact early use NMBAs on 90-day mortality, through propensity score (PS) matching analysis. Methods We analyzed a convenience sample and ARDS, admitted 244 intensive care units within Critical Care Consortium, from February 1, 2020,...
Abstract Background During the first coronavirus disease 2019 (COVID-19) pandemic wave, an unprecedented number of patients with respiratory failure due to a new, highly contagious virus needed hospitalization and intensive care unit (ICU) admission. The aim present study was describe communication visiting policies Italian units (ICUs) during COVID-19 wave national lockdown compare these data prepandemic conditions. Methods A web-based survey conducted among 290 hospitals. Each ICU (active...
BACKGROUND: Lombardy was the epicenter of first coronavirus disease 2019 (COVID-19) outbreak in western countries. The began February 2020 and rapidly disseminated throughout region. ICU beds were vastly insufficient clinical knowledge poor at that time. Unfortunately, data on long-term mortality, morbidity, Quality Life are scarce controversial. aim this study to evaluate 1-year survival, Life, functional recovery patients with COVID-19 admitted Intensive Care Units.METHODS: All invasively...
Acute kidney injury (AKI) is frequent in critically ill COVID-19 patients and associated with a higher mortality risk. By increasing intrathoracic pressure, positive pressure ventilation (PPV) may reduce renal perfusion by reducing venous return to the heart or congestion. This study's aim was evaluate association between AKI haemodynamic ventilatory parameters ARDS.
Acute hypoxemic respiratory failure (AHRF) is a life-threatening complication of COVID-19 pneumonia. Noninvasive ventilation (NIV) might be useful in its initial management.1 However, vigorous inspiratory effort during spontaneous breathing (SB) may worsen lung injury, generating excessive stress and strain.2 Tonelli et al3 showed how the change NIV, not oxygenation, was earliest most accurate parameter to predict NIV failure. Prone position (PP) act synergy with reduce efforts, by more...
A 21-year-old patient has been treated in emergency with venovenous extracorporeal membrane oxygenation after severe thoracic trauma causing air leak and haemothorax. The assistance was managed without heparin for 10 days till the full recovery of lung, no side-effect recorded.
The performance of viscoelastic coagulation monitor (VCM) compared with TEG 5000 (TEG) is unknown. In this multicenter study, the authors evaluated agreement among VCM/TEG parameters and their relationship standard tests in critically ill patients. Viscoelastic monitor, TEG, laboratory samples were analyzed simultaneously. monitor/TEG was computed by Bland Altman’s plots, association studied Spearman’s correlation coefficient random-intercept linear models. One-hundred twenty-seven patients...