A5069509749- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Hemodynamic Monitoring and Therapy
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- High Altitude and Hypoxia
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular and Diving-Related Complications
- Pituitary Gland Disorders and Treatments
- Pulmonary Hypertension Research and Treatments
- Nutrition and Health in Aging
- COVID-19 Clinical Research Studies
- Lipoproteins and Cardiovascular Health
- Medication Adherence and Compliance
- Vitamin D Research Studies
- Body Composition Measurement Techniques
- Hypothalamic control of reproductive hormones
- Respiratory Support and Mechanisms
- Cardiovascular and exercise physiology
- Ovarian function and disorders
- Cardiac Imaging and Diagnostics
- Tracheal and airway disorders
- Long-Term Effects of COVID-19
- Diabetes Treatment and Management
IRCCS Istituto Auxologico Italiano
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2024
University of Milan
2014-2023
University of Milano-Bicocca
2012-2021
Washington University in St. Louis
2021
Maastricht University
2017
RWTH Aachen University
2017
Medical University of Vienna
2017
Lombardia Informatica (Italy)
2015
Regione Lombardia
2015
Background: The confinement recommended during COVID-19 pandemic could affect behavior and health. Methods: We conducted a self-reported survey in northern Italy to observe the lockdown effects on lifestyle changes assess their determinants. Prevalence Odds Ratio Risk were determined. Results: 490 adults (84% female) completed survey: 13% 43% reported improved unchanged sleep quality, respectively, while had insomnia symptoms. Among 272 active subjects pre-lockdown, 14% continued habitual...
Abstract Aims In patients with atrial fibrillation (AF) and heart failure (HF), strict regular rate control atrioventricular junction ablation biventricular pacemaker (Ablation + CRT) has been shown to be superior pharmacological in reducing HF hospitalizations. However, whether it also improves survival is unknown. Methods results this international, open-label, blinded outcome trial, we randomly assigned severely symptomatic permanent AF >6 months, narrow QRS (≤110 ms) at least one...
Abstract Background Vitamin D deficiency has been suggested to favor a poorer outcome of Coronavirus disease-19 (COVID-19). We aimed assess if 25-hydroxyvitamin-D (25OHD) levels are associated with interleukin 6 (IL-6) and disease severity mortality in COVID-19. Methods prospectively studied 103 in-patients admitted Northern-Italian hospital (age 66.1 ± 14.1 years, 70 males) for severely-symptomatic Fifty-two subjects SARS-CoV-2 infection but mild COVID-19 symptoms (mildly-symptomatic...
To investigate the relationship between adherence with statin therapy and risk of developing diabetes.The cohort comprised 115,709 residents Italian Lombardy region who were newly treated statins during 2003 2004. Patients followed from index prescription until 2010. During this period, patients began an antidiabetic agent or hospitalized for a main diagnosis type 2 diabetes identified (outcome). Adherence was measured by proportion days covered (PDC) (exposure). A proportional hazards model...
Abstract Aims Diagnostic criteria for ambulatory blood pressure monitoring (ABPM) in patients with suspected reflex syncope are lacking. The study hypothesis was that have a higher prevalence of systolic (SBP) drops on ABPM. Methods and results ABPM data from controls, matched by average 24 h SBP, age, sex, hypertension were compared. Patients constitutional hypotension, orthostatic predominant cardioinhibition during carotid sinus massage or prolonged electrocardiogram competing causes...
Systolic blood pressure (SBP) drops recorded by 24-h ambulatory (BP) monitoring (ABPM) identify patients with susceptibility to reflex syncope and orthostatic intolerance. We tested the hypothesis that treatments aimed increase BP (reassurance, education, lifestyle measures plus pharmacological strategies) can reduce SBP drops.
We have previously shown that in Italian region of Lombardy (about 10 million citizens), adherence to antihypertensive treatment is low, and this associated with a greater risk hospitalization for cardiovascular events. In study, we used healthcare database study the factors involved discontinuation drug prescriptions real life.The analysis was restricted 493 623 new users drugs (no previous 3 years) recruited 2003, 2006 2009. Discontinuation defined as lack prescription renewal at least...
Randomized clinical trials have shown that antihypertensive treatment reduces the risk of heart failure (HF). Limited evidence exists, however, on whether and to what extent this benefit is translated into real-life practice. A nested case–control study was carried out by including cohort 76 017 patients from Lombardy (Italy), aged 40 80 years, who were newly treated with drugs during 2005. Cases 622 experienced hospitalization for HF initial prescription until 2012. Up 5 controls randomly...
We hypothesized that cardiovascular physiology differs in reflex syncope patients compared with the general population, predisposing such individuals to vasovagal reflex.
Among patients with heart failure preserved ejection fraction (HFpEF), a distinct hemodynamic phenotype has been recently described, ie, latent pulmonary vascular disease (HFpEF-latentPVD), defined by exercise resistance (PVR) >1.74 WU.This study aims to explore the pathophysiological significance of HFpEF-latentPVD.The authors analyzed cohort who had undergone supine right catheterization cardiac output (CO) measured direct Fick method, between 2016 and 2021. HFpEF-latentPVD were compared...
Enhanced glutamatergic transmission leading to motor neuron death is considered the major pathophysiological mechanism of amyotrophic lateral sclerosis (ALS). Motor cortex excitability can be suppressed by transcranial static magnetic stimulation (tSMS), thus tSMS evaluated as a potential treatment for ALS. The aim present study was investigate efficacy and safety in
Background Twenty-four-hour blood pressure variability (BPV) is independently related to cardiovascular outcomes, but limited and conflicting evidence available on the relative prognostic importance of systolic diastolic BPV. The aim this study was verify hypothesis that association over 24 h with mortality in untreated subjects affected by age. Design methods included 9154 individuals assessed for hypertension between 1982 2002 frame Dublin Outcome Study, which ambulatory monitoring...
Background: Rituximab (RTX), a chimeric human-murine anti-CD20 monoclonal antibody, has been used for treatment of active moderate-severe Graves' orbitopathy (GO) since 2004 as second-line therapy in patients unresponsive to intravenous steroids. We conducted an open-label prospective study (EUDRACT 2012-001980-53) which were treated with single infusion only 100 mg RTX analyze the efficacy and safety this low dose. Methods: Seventeen patients, whom nine had disease that was...