A5063487192- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Arrhythmias and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Neurology and Historical Studies
- Cardiac pacing and defibrillation studies
- Psychosomatic Disorders and Their Treatments
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Migraine and Headache Studies
- Venous Thromboembolism Diagnosis and Management
- Congenital Heart Disease Studies
- Ion channel regulation and function
- Takotsubo Cardiomyopathy and Associated Phenomena
- ECG Monitoring and Analysis
- Non-Invasive Vital Sign Monitoring
- ICT Impact and Policies
- Prenatal Screening and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Pathogenesis and Treatment of Hiccups
- Cardiac Arrest and Resuscitation
- Ophthalmology and Eye Disorders
University of Calgary
2016-2025
Libin Cardiovascular Institute of Alberta
2016-2025
RELX Group (United States)
2024
RELX Group (United Kingdom)
2024
Calgary Laboratory Services
1995-2022
Group W (United States)
2016-2021
Vanderbilt University Medical Center
2021
University of Würzburg
2021
Alberta Bible College
2021
University of Alberta
2019
Background —Patients surviving ventricular fibrillation (VF) or sustained tachycardia (VT) are at a high risk of death due to recurrence arrhythmia. The implantable cardioverter defibrillator (ICD) terminates VT VF, but it is not known whether this device prolongs life in these patients compared with medical therapy amiodarone. Methods and Results —A total 659 resuscitated VF unmonitored syncope were randomly assigned treatment the ICD primary outcome measure was all-cause mortality,...
Three previous small randomized trials have reported that pacemaker therapy is beneficial for patients with severe recurrent vasovagal syncope. However, because these were not double blind, they may been biased in their assessment of outcomes and had a placebo effect surgery.To determine if pacing reduces the risk syncope syncope.A double-blind trial outpatients referred to specialists at 15 centers from September 1998 April 2002. In year prior randomization, median 4 episodes Patients...
Patients with postural tachycardia syndrome (POTS) experience chronic symptoms of orthostatic intolerance. There are minimal data detailing the demographics, clinical features and course this condition. This online, community-based survey highlights patients' POTS. It consists largest sample POTS patients reported to date.To describe past medical history, medications, treatments diagnostic journey for living POTS.Postural completed an community-based, cross-sectional survey. Participants...
Background —Although sex differences in coronary artery disease have received considerable attention, few studies dealt with the most common sustained cardiac arrhythmia, atrial fibrillation (AF). Differences presentation and clinical course may dictate different approaches to detection management. We sought examine sex-related presentation, treatment, outcome patients presenting new-onset AF. Methods Results —The Canadian Registry of Atrial Fibrillation (CARAF) enrolled subjects at time...
Previous studies that assessed the effects of beta-blockers in preventing vasovagal syncope provided mixed results. Our goal was to determine whether treatment with metoprolol reduces risk patients syncope.The multicenter Prevention Syncope Trial (POST) a randomized, placebo-controlled, double-blind, trial designed assess over 1-year period. Two prespecified analyses included relationships age and initial tilt-test results any benefit from metoprolol. All had >2 syncopal spells positive tilt...
Methods and results We administered a 118-item historical questionnaire to 418 patients with syncope no apparent structural heart disease. The prevalence of each item was compared between positive tilt tests those other, known causes. contributions symptoms diagnoses were estimated logistic regression, point scores developed, the tested using receiver operator characteristic analysis. accuracy decision rule assessed bootstrapping. Data sets complete for all subjects. causes in 323 included...
Expression of cardiac transient outward current and inwardly rectifying K + is age dependent. However, little known about age-related changes in delayed rectifier (I , with rapidly slowly activating components, I Kr Ks respectively). Accordingly, the purpose present study was to assess developmental channels fetal, neonatal, adult mouse ventricles. Three techniques were used: conventional microelectrode measure action potential, voltage clamp record macroscopic currents radioligand assay...
Aims To determine the effect of family history on likelihood vasovagal syncope. Methods and results Sixty-two medical students 228 first-degree relatives were studied. Vasovagal syncope was ascertained with Calgary symptom score. The effects sex subject parental offspring fainting described using Kaplan–Meier estimates analysed proportional hazards regression. prevalence 32% median age first faint in those who fainted 14 years. More females than males [42 vs. 31%; P=0.02; hazard ratio (HR)...
Background —Patients with resuscitated ventricular tachyarrhythmias (ventricular tachycardia/ventricular fibrillation) benefit from implantable cardioverter-defibrillators (ICDs) compared medical therapy. We hypothesized that the patients who most an ICD are those at greatest risk of death. Methods and Results —In Canadian Implantable Defibrillator Study (CIDS), 659 were randomly assigned to receive or amiodarone then followed for a mean 3 years. There 98 83 deaths in groups, respectively....
The conventional approach to the diagnosis and treatment of severe knee injuries is arthroscopy, a minimally invasive surgical procedure. Since arthroscopy an technique that carries risks, magnetic resonance imaging (MRI) increasingly being used for diagnosis. MRI potentially associated with diagnostic therapeutic 'impacts', in can be avoided. This paper reports discrete choice conjoint analysis exercise assessed value placed on such 'impacts' by potential patients investigated degree which...
Introduction: Understanding whether vasovagal syncope is a lifelong disorder might shed insight into its physiology and affect management strategies. Accordingly, we determined the age of first syncopal spell in adult patients who sought care for syncope. Methods Results: Patients were 42 ± 18 years old with 64% women. They had median 8 spells (interquartile range [IQR]: 4, 20) frequency 1.0 per year. The was 1–3,375, duration history 0.003–70 years. occurred at ages 0–81 skewed...
Chemotherapy is frequently used to treat adenocarcinoma. Thirty-nine cases are reviewed in which the patients developed a hemolytic-uremic-like syndrome, apparently response chemotherapy. About 44% of had gastric adenocarcinoma, and 82% received mitomycin C. Most (75%) syndrome 6 12 months after starting chemotherapy, 60% were remission. Severe microangiopathic hemolytic anemia, thrombocytopenia, renal impairment each noted about 90% cases. Neurologic symptoms usually absent, but 49% adult...
Vasovagal syncope (VVS) patients have a reduced health-related quality of life (HRQoL). There are limited data comparing HRQoL and psychological profile in VVS healthy individuals. We tested the hypothesis that greater impairment both compared to nonfainting individuals, outcome measures negatively correlated for patients.The RAND 36-Item Health Survey (RAND36), global health visual analogue scale (VAS), Hospital Anxiety Depression Scale, Sensitivity Index, Positive Negative Affect Schedule...