A5027601597- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Neurological Disorders and Treatments
- Microbial Natural Products and Biosynthesis
- Cardiovascular Syncope and Autonomic Disorders
- Genetics, Bioinformatics, and Biomedical Research
- Marine Sponges and Natural Products
- Ion channel regulation and function
- Health Systems, Economic Evaluations, Quality of Life
- ECG Monitoring and Analysis
- Antibiotic Use and Resistance
- Cardiac Imaging and Diagnostics
- Dementia and Cognitive Impairment Research
- Cardiovascular Function and Risk Factors
- Obstructive Sleep Apnea Research
- Heart Failure Treatment and Management
- Non-Invasive Vital Sign Monitoring
- COVID-19 diagnosis using AI
- Machine Learning in Healthcare
- Microbial Community Ecology and Physiology
- Neurobiology of Language and Bilingualism
- Blood Pressure and Hypertension Studies
University of Toronto
2010-2025
Sunnybrook Health Science Centre
2013-2025
Health Sciences Centre
2006-2025
Florida Atlantic University
2014-2024
Memorial Medical Center
2022-2023
Edward Via College of Osteopathic Medicine
2022
Unity Health System
2022
Alexion Pharma (Switzerland)
2021
Canada Research Chairs
2020
Atlantic University College
2019
Evidence suggests that physiologic pacing (dual-chamber or atrial) may be superior to single-chamber (ventricular) because it is associated with lower risks of atrial fibrillation, stroke, and death. These benefits have not been evaluated in a large, randomized, controlled trial.At 32 Canadian centers, patients without chronic fibrillation who were scheduled for first implantation pacemaker treat symptomatic bradycardia eligible enrollment. We randomly assigned receive either ventricular...
Background —Although sex differences in coronary artery disease have received considerable attention, few studies dealt with the most common sustained cardiac arrhythmia, atrial fibrillation (AF). Differences presentation and clinical course may dictate different approaches to detection management. We sought examine sex-related presentation, treatment, outcome patients presenting new-onset AF. Methods Results —The Canadian Registry of Atrial Fibrillation (CARAF) enrolled subjects at time...
To determine the proportion of patients who can be treated with early switch to oral antibiotics and discharge, evaluate clinical outcome patient satisfaction for define factors that interfere discharge some underwent antibiotic therapy.Prospective study.Two hundred consecutive hospitalized community-acquired pneumonia.Number days needed therapy length hospital stay. Clinical care were evaluated those discharge.Early (within first 3 hospitalization) was performed in 133 (67%). failure...
The Canadian Trial of Physiological Pacing (CTOPP) reported that the risk stroke or cardiovascular death was similar between patients receiving ventricular versus physiological pacemakers at end original follow-up period 3 years. However, occurrence atrial fibrillation significantly less frequent with pacemakers. To assess a potential delayed benefit pacing, in this study extended to 6 years.A total 1474 requiring pacemaker for symptomatic bradycardia were randomized receive and 1094 primary...
The implantable cardioverter defibrillator (ICD) is superior to amiodarone for secondary prophylaxis of sudden cardiac death. However, the magnitude this benefit over long-term follow-up not known. Thus, our objective was evaluate consequences using versus an ICD as first-line monotherapy in patients with a prior history sustained ventricular tachycardia/ventricular fibrillation or arrest.A total 120 were enrolled at St Michael's Hospital Canadian Implantable Defibrillator Study (CIDS) and...
The advent of genomic diagnostic technologies such as next-generation sequencing has recently enabled the use information to guide targeted treatment in patients with cancer, an approach known precision medicine. However, clinical outcomes, including survival and cost health care associated cancer medicine, have been challenging measure remain largely unreported.We conducted a matched cohort study 72 metastatic diverse subtypes setting large, integrated delivery system. We analyzed outcomes...
Background Obstructive sleep apnea (OSA) is a systemic disorder associated with significant cardiovascular complications. OSA may play role in the initiation and worsening of atrial fibrillation (AF). This study aimed to determine prevalence clinical predictors patients AF. Hypothesis underdiagnosed large number AF not be predicted by conventional indices. Methods Consecutive nonselected were recruited from different arrhythmia clinics Toronto, Ontario, Canada. Patients previous diagnosis...
Background —Some clinical data suggest that atrial-based pacing prevents paroxysmal atrial fibrillation (AF). This study tested the hypothesis DDDR compared with VDD AF after atrioventricular (AV) junction ablation. Methods and Results —Patients were randomized to (n=33) or (n=34) AV ablation followed every 2 months for 6 months. Patients then crossed over alternate mode an additional Primary analysis included time first recurrence of sustained (duration >5 minutes), total burden,...
Patients with nonvalvular atrial fibrillation and prior stroke or transient ischemic attack (TIA) are at high risk for recurrent stroke. We investigated whether ximelagatran was noninferior to warfarin in patients TIA.We analyzed pooled data from the SPORTIF III V trials stroke/TIA. The primary outcome composite annual rate of both hemorrhagic strokes systemic embolic events. Secondary analyses considered separately, bleeding, nonrandomized, concomitant therapy aspirin < =100 mg/d.Patients...
Angela Kydd and colleagues compare data from three countries to assess what staff think about working in the specialty