A5077613101- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Reproductive Biology and Fertility
- Hypothalamic control of reproductive hormones
- Neuroendocrine Tumor Research Advances
- Ovarian function and disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Congenital heart defects research
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Adrenal and Paraganglionic Tumors
- Genetic Syndromes and Imprinting
- Neuroblastoma Research and Treatments
- Renal and related cancers
- Adrenal Hormones and Disorders
- Estrogen and related hormone effects
- Thyroid and Parathyroid Surgery
- Animal Genetics and Reproduction
- Neonatal Health and Biochemistry
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
IRCCS Istituto Auxologico Italiano
2016-2025
University of Milan
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Fondazione IRCCS Istituto Nazionale dei Tumori
2024
Rutgers, The State University of New Jersey
2024
Hospital General de Niños Ricardo Gutierrez
2024
Monash University
2024
Royal Manchester Children's Hospital
2024
University Hospital in Motol
2024
Bambino Gesù Children's Hospital
2024
G-protein-coupled receptors (GPCRs) are generally thought to signal second messengers like cyclic AMP (cAMP) from the cell surface and become internalized upon repeated or prolonged stimulation. Once internalized, they supposed stop signaling but may trigger nonclassical signals such as mitogen-activated protein kinase (MAPK) activation. Here, we show that a GPCR continues stimulate cAMP production in sustained manner after internalization. We generated transgenic mice with ubiquitous...
The term "TSH-secreting pituitary tumors" includes two opposite clinical conditions: true thyrotroph neoplasia that results in secondary hyperthyroidism, also called "central hyperthyroidism," and hyperplasia resulting from longstanding primary hypothyroidism. latter condition was first recognized 145 yr ago (1), while the former not clearly identified until RIA era (2–8). However, 1950s 1960s, it became clear Graves' disease caused by hyperpituitarism (9, 10), scattered reports suggested a...
Central hypothyroidism (CeH) is a rare form of characterized by insufficient thyroid stimulation due to disturbed pituitary and/or hypothalamic functioning. Due its origin and the whole clinical context, CeH represents challenging condition in practice as it suboptimal accuracy biochemical parameters for diagnosis management. Since no expert consensus or guidance this currently available, task force experts received commitment from European Thyroid Association (ETA) prepare document based on...
Benign thyroid nodules are a common clinical occurrence and usually do not require treatment unless symptomatic. During the last years, ultrasound-guided minimally invasive treatments (MIT) gained an increasing role in management of causing local symptoms. In February 2018, Italian MIT Thyroid Group was founded to create permanent cooperation between international physicians dedicated research assistance on for nodules. The group drafted this list statements based literature review consensus...
Abstract Purpose The 14th Acromegaly Consensus Conference was convened to consider biochemical criteria for acromegaly diagnosis and evaluation of therapeutic efficacy. Methods Fifty-six experts from 16 countries reviewed discussed current evidence focused on assays; the role imaging, pathology, clinical assessments; consequences diagnostic delay; remission recommendations follow up; value assessment monitoring in defining disease progression, selecting appropriate treatments, maximizing...
Summary Context The guidelines of the National Academy Clinical Biochemistry advocated use low bloodspot TSH (b‐TSH) threshold for newborn screening congenital hypothyroidism (CH). impact generated by application this indication is largely unknown. Objective To determine on CH epidemiology and classification introduction b‐TSH cutoff. Design Retrospective study 629,042 newborns screened with cutoffs 12 (years 1999–2002) or 10 mU/l (2003–2005). Measurements Congenital incidence...
The occurrence of thyroid abnormalities and the appearance organ- non-organ-specific autoantibodies during long-term recombinant interferon alpha-2a (IFN-alpha) therapy were studied in 86 51 consecutive outpatients with hepatitis C B virus-related chronic active (CAH-HCV CAH-HBV), respectively. Most patients had longstanding community-acquired hepatitis. At baseline, 9.3% CAH-HCV 3.9% CAH-HBV showed clinical and/or biochemical signs dysfunction. remaining euthyroid, although anti-thyroid...
Genetic mutations with major effects on ovulation rate and litter size in sheep were recently identified three genes belonging to the TGFβ superfamily pathway: bone morphogenetic protein 15 (BMP15, also known as GDF9b), growth differentiation factor 9 (GDF9), BMP receptor type IB (also activin-like kinase 6). Homozygous BMP15 or GDF9 raise female sterility due a failure of normal ovarian follicle development, whereas heterozygous animals for well homozygous show increased rates. In present...
Premature ovarian failure (POF) is a cause of female infertility characterized by primary (PA) or secondary amenorrhea (SA) and elevated gonadotropins. The pathogenesis unknown in most cases. We recently reported two sisters with PA carrying heterozygous mutation BMP15 gene (locus Xp11.2), but the prevalence variations POF population unknown.The objective study was to verify involvement large population.Genetic screening 166 unrelated patients idiopathic (25 PA, 141 SA) controls (group A: 95...
LH activates a cascade of signaling events that are propagated throughout the ovarian preovulatory follicle to promote ovulation mature egg. Critical LH-induced is induction epidermal growth factor (EGF)-like factors and transactivation EGF receptor (EGFR) signaling. Because timing this has not been well characterized, we investigated dynamics regulation network in cultured follicles. Preovulatory follicles were with or without recombinant and/or specific inhibitors. EGFR MAPK...