A5012997123- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Helicobacter pylori-related gastroenterology studies
- Celiac Disease Research and Management
- Thyroid Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Gastroesophageal reflux and treatments
- Birth, Development, and Health
- Infant Health and Development
- Diabetes and associated disorders
- Metabolism and Genetic Disorders
- Hormonal and reproductive studies
- Infant Nutrition and Health
- Iron Metabolism and Disorders
- Neonatal Health and Biochemistry
- Diabetes Management and Research
- Childhood Cancer Survivors' Quality of Life
- Pharmacological Effects and Toxicity Studies
- Gastrointestinal motility and disorders
- Bone Metabolism and Diseases
- Genetic Syndromes and Imprinting
- Digestive system and related health
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Microbial Metabolites in Food Biotechnology
Marche Polytechnic University
2024
University of Milan
2006-2020
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2020
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
2020
University of Bari Aldo Moro
2008-2017
Ospedale Pediatrico Giovanni XXIII
2012-2016
Health and Human Development (2HD) Research Network
2016
University of Foggia
2013
British Columbia Children's Hospital
2007
University Children’s Hospital Bern
2007
Our aim was to determine whether Lactobacillus rhamnosus GG (LGG) relieves symptoms in children with recurrent abdominal pain.A total of 141 irritable bowel syndrome (IBS) or functional pain were enrolled 9 primary care sites and a referral center. Children entered randomized, double-blind, placebo-controlled trial received LGG placebo for 8 weeks follow-up weeks. The outcome overall at the end intervention period. At entry trial, underwent double-sugar intestinal permeability test.Compared...
Premature ovarian failure (POF) is a cause of female infertility characterized by primary (PA) or secondary amenorrhea (SA) and elevated gonadotropins. The pathogenesis unknown in most cases. We recently reported two sisters with PA carrying heterozygous mutation BMP15 gene (locus Xp11.2), but the prevalence variations POF population unknown.The objective study was to verify involvement large population.Genetic screening 166 unrelated patients idiopathic (25 PA, 141 SA) controls (group A: 95...
Heterozygous, de novo mutations in the transcription factor SOX2 are associated with bilateral anophthalmia or severe microphthalmia and hypopituitarism. Variable additional abnormalities include defects of corpus callosum hippocampus.We have ascertained a further three patients eye pituitary who were screened for SOX2. To provide evidence direct role hypothalamo-pituitary development, we studied expression gene human embryonic tissues.All harbored heterozygous mutations: deletion...
Summary Background Helicobacter pylori eradication fails in about 25–30% of children, particularly because the occurrence resistance to antibiotics and side‐effects. Aim To determine whether adding Lactobacillus reuteri an anti‐ H. regimen could help prevent or minimize gastrointestinal side‐effects burden children. Methods Forty ‐positive children (21 males; median age: 12.3 years) were consecutively treated with 10‐day sequential therapy [omeprazole + amoxycillin for 5 days, omeprazole...
Abstract Background: Several studies report an inhibitory effect of probiotics on Helicobacter pylori . Aim: To test whether Lactobacillus reuteri ATCC 55730 reduces H. intragastric load in vivo, decreases dyspeptic symptoms, and affects eradication rates after conventional treatment. Materials Methods: In a double‐blind placebo‐controlled study, 40 ‐positive subjects were given L. once day for 4 weeks or placebo. All underwent upper endoscopy, 13 C‐urea breath test, stool antigen...
The goals of this study were to investigate the role a new probiotic preparation (Lactobacillus reuteri DSM 17938 and L. ATCC PTA 6475) in Helicobacter pylori infection.Specific strains play H. infection for their ability decrease bacterial load gastritis, prevent antibiotic-associated side effects, increase eradication rate.This is prospective, double-blind, randomized, placebo-controlled tertiary care setting. A total 100 pylori-positive naive patients received either combination (2×10...
Young infants are frequently affected by uncomplicated regurgitation that may persist despite dietetic and conservative interventions. On this basis, we studied the putative effects of probiotics on frequency gastric emptying time in with functional gastroesophageal reflux (GER).Forty-two were randomized to assume Lactobacillus reuteri DSM 17938 at a dose 1 × 10(8) CFU per day placebo for 30 days. The episodes recorded parents each day. Gastric was using real-time ultrasound baseline end...
Summary Background Probiotics may be of help for the management acute diarrhoea, however, effect is strain specific and efficacy needs to proven. Aim To test safety L actobacillus reuteri DSM 17938 derived from . ATCC 55730 in children with diarrhoea. Primary outcomes were rate unresolved diarrhoea after 3 days treatment duration Methods Children (6–36 months), hospitalised three paediatric hospitals S outhern I taly clinical signs dehydration randomised receive a double‐blind fashion either...
The aim of this study was to investigate the alterations in oxidant/antioxidant status obese children with and without metabolic syndrome (MetS).We recruited 25 Caucasian MetS, 30 simple obesity a control group children. We performed diacron-reactive oxygen metabolites (d-ROMs) test biological antioxidant potential (BAP) order evaluate oxidant-antioxidant patients.d-ROM level significantly higher MetS (p = 0.005). total capacity (BAP level) reduced noMetS compared controls 0.009). subjects...
Childhood type 1 diabetes mellitus (T1DM) is associated with decreased bone mass. Sclerostin and dickkopf-1 (DKK-1) are Wnt inhibitors that regulate formation.To evaluate sclerostin DKK-1 levels in T1DM children to analyze the influence of glycemic control on health.Cross-sectional study conducted at a clinical research center.One hundred six subjects (12.2 ± 4 years), 66 multiple daily injections (MDIs) 40 continuous subcutaneous infusion insulin (CSII), 80 controls.The average transmission...
OBJECTIVE In children with type 1 diabetes mellitus (T1DM), elevated levels of antitissue transglutaminase (anti-tTG) antibody may spontaneously normalize, despite continued consumption gluten. We aimed to investigate the prevalence spontaneous normalization anti-tTG and existence factors predictive for this outcome. RESEARCH DESIGN AND METHODS All referred from 2002 2012 were screened celiac disease (CD) at onset specific intervals. presence a high titer or clinical symptoms, offered...
Diabetes mellitus was observed in 29 of 448 patients with thalassaemia major attending seven Italian centres. Twelve patients, at onset clinical diabetes, presented an asymptomatic glycosuria, 13 ketosis, and four ketoacidosis. All were diagnosed after 1979, a mean age 17 years. Mean diagnosis diabetes lower born the last two decades. In these transfusions started younger pre-transfusion haemoglobin concentration, serum ferritin incidence liver disease, presence family history higher than...
Multichannel intraluminal impedance (MII) is a pH-independent method of assessing gastroesophageal reflux.To evaluate the diagnostic accuracy MII-pH as compared with conventional pH monitoring in detecting reflux events (REs) and symptom association different age groups.: A prospective direct comparison 2 techniques on 291 consecutive patients referred for suspected disease. Sensitivity versus were measured.MII-pH detected 13631 REs, 6260 (46%) which nonacid. The prevalence weakly acid...
The aim of this double-blind, randomized, placebo-controlled study was to evaluate the effect a prebiotic mixture on gastric motility in preterm newborns. After feeding period 15 days, electrical activity measured by electrogastrography, and emptying time studied ultrasound technique. No difference seen daily increase body weight, no adverse events have been reported. percentage which propagation detected electrogastrography signal twice newborns receiving formula with prebiotics respect...
<b><i>Background/Aims:</i></b> We studied the association of low birth weight with ultrasound-assessed nonalcoholic fatty liver disease (NAFLD) to test hypothesis that fetal growth retardation followed by a rapid catch-up might be an additional factor responsible for steatosis via insulin resistance (IR) and/or intra-abdominal fat. <b><i>Methods:</i></b> enrolled 23 children born small gestational age (SGA) within first 6-12 months, and 24...