A5088254871- Cardiac Arrhythmias and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Trypanosoma species research and implications
- Cardiomyopathy and Myosin Studies
- Research on Leishmaniasis Studies
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Psychosomatic Disorders and Their Treatments
- Obstructive Sleep Apnea Research
- Health Systems, Economic Evaluations, Quality of Life
- Neurology and Historical Studies
- Respiratory and Cough-Related Research
- Venous Thromboembolism Diagnosis and Management
- Takotsubo Cardiomyopathy and Associated Phenomena
- Botulinum Toxin and Related Neurological Disorders
- Viral Infections and Immunology Research
- Cardiovascular Health and Disease Prevention
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Structural Anomalies and Repair
University of Calgary
2012-2025
Libin Cardiovascular Institute of Alberta
2012-2025
Spanish National Centre for Cardiovascular Research
2024-2025
Foothills Medical Centre
2013-2024
Centre for Automation and Robotics
2023
Universidad Politécnica de Madrid
2023
Hospital Felício Rocho
2023
Hospital das Clínicas da Universidade Federal de Minas Gerais
2023
IRCCS Istituto Auxologico Italiano
2022
Calgary Laboratory Services
2011-2022
Catheter ablation is less successful for persistent atrial fibrillation than paroxysmal fibrillation. Guidelines suggest that adjuvant substrate modification in addition to pulmonary-vein isolation required fibrillation.We randomly assigned 589 patients with a 1:4:4 ratio alone (67 patients), plus of electrograms showing complex fractionated activity (263 or additional linear across the left roof and mitral valve isthmus (259 patients). The duration follow-up was 18 months. primary end point...
The ESC Guidelines represent the views of and were arrived at after careful consideration available evidence time they written.Health professionals are encouraged to take them fully into account when exercising their clinical judgement.The guidelines do not, however, override individual responsibility health make appropriate decisions in circumstances patients, consultation with that patient, where necessary patient's guardian or carer.It is also professional's verify rules regulations...
Current guidelines recommend at least 24 hours of electrocardiographic (ECG) monitoring after an ischemic stroke to rule out atrial fibrillation. However, the most effective duration and type have not been established, cause remains uncertain despite a complete diagnostic evaluation in 20 40% cases (cryptogenic stroke). Detection fibrillation cryptogenic has therapeutic implications.We conducted randomized, controlled study 441 patients assess whether long-term with insertable cardiac...
One quarter of strokes are unknown cause, and subclinical atrial fibrillation may be a common etiologic factor. Pacemakers can detect episodes rapid rate, which correlate with electrocardiographically documented fibrillation. We evaluated whether rate detected by implanted devices were associated an increased risk ischemic stroke in patients who did not have other evidence fibrillation.We enrolled 2580 patients, 65 years age or older, hypertension no history fibrillation, whom pacemaker...
Background Despite the clinical importance of atrial fibrillation (AF), development chronic nonvalvular AF models has been difficult. Animal sustained have developed primarily in short-term setting. Recently, ventricular myopathy and after several weeks continuous rapid pacing. We hypothesized that pacing would lead to myopathy, yielding a reproducible model AF. Methods Results Twenty-two halothane-anesthetized mongrel dogs underwent insertion transvenous at right appendage was continuously...
We conducted a prospective, multicenter, randomized study involving 2854 patients with Chagas' cardiomyopathy who received benznidazole or placebo for up to 80 days and were followed mean of 5.4 years. The primary outcome in the time-to-event analysis was first event any components composite death, resuscitated cardiac arrest, sustained ventricular tachycardia, insertion pacemaker implantable cardioverter–defibrillator, transplantation, new heart failure, stroke, other thromboembolic event.
Background— Among patients with implantable pacemakers and defibrillators, subclinical atrial fibrillation (SCAF) is associated an increased risk of stroke; however, there limited understanding their temporal relationship. Methods Results— The Asymptomatic Atrial Fibrillation Stroke Evaluation in Pacemaker Patients the Reduction Pacing Trial (ASSERT) enrolled 2580 pacemaker defibrillator aged ≥65 years a history hypertension but without fibrillation. Pacemakers cardioverter-defibrillators...
<h3>Importance</h3> Atrial fibrillation (AF) is the most common rhythm disorder seen in clinical practice. Antiarrhythmic drugs are effective for reduction of recurrence patients with symptomatic paroxysmal AF. Radiofrequency ablation an accepted therapy whom antiarrhythmic have failed; however, its role as a first-line needs further investigation. <h3>Objective</h3> To compare radiofrequency (standard therapy) treating AF therapy. <h3>Design, Setting, and Patients</h3> A randomized trial...
Guidelines recommend a trial of one or more antiarrhythmic drugs before catheter ablation is considered in patients with atrial fibrillation. However, first-line may be effective maintaining sinus rhythm. We randomly assigned 303 symptomatic, paroxysmal, untreated fibrillation to undergo cryothermy balloon receive drug therapy for initial rhythm control. All the received an implantable cardiac monitoring device detect tachyarrhythmia. The follow-up period was 12 months. primary end point...
ASSERT demonstrated that subclinical atrial fibrillation (SCAF) is common in pacemaker patients without prior AF and associated with increased risk of ischemic stroke or systemic embolism. SCAF episodes vary duration little known about the incidence different durations SCAF, their prognosis.ASSERT followed 2580 receiving a ICD, aged >65 years hypertension, AF. The effect on subsequent embolism was evaluated time-dependent covariate Cox models. Patients whom longest ≤6 min were excluded from...
Dronedarone restores sinus rhythm and reduces hospitalization or death in intermittent atrial fibrillation. It also lowers heart rate blood pressure has antiadrenergic potential ventricular antiarrhythmic effects. We hypothesized that dronedarone would reduce major vascular events high-risk permanent fibrillation.We assigned patients who were at least 65 years of age with a 6-month history fibrillation risk factors for to receive placebo. The first coprimary outcome was stroke, myocardial...
Three previous small randomized trials have reported that pacemaker therapy is beneficial for patients with severe recurrent vasovagal syncope. However, because these were not double blind, they may been biased in their assessment of outcomes and had a placebo effect surgery.To determine if pacing reduces the risk syncope syncope.A double-blind trial outpatients referred to specialists at 15 centers from September 1998 April 2002. In year prior randomization, median 4 episodes Patients...
Background— Atrial fibrillation (AF) is the most common sustained arrhythmia; however, little known about patients in a primary care setting from high-, middle-, and low-income countries. Methods Results— This prospective registry enrolled presenting to an emergency department with AF at 164 sites 46 countries representing all inhabited continents. Patient characteristics were compared among 9 major geographic regions. Between September 2008 April 2011, 15 400 enrolled. The average age was...
AimsThis multicentre, randomized trial compared three strategies of AF ablation: ablation complex fractionated electrograms (CFE) alone, pulmonary vein isolation (PVI) and combined PVI + CFE ablation, using standardized automated mapping software.
The DISCERN AF study (Discerning Symptomatic and Asymptomatic Episodes Pre Post Radiofrequency Ablation of Atrial Fibrillation) monitored atrial fibrillation (AF) using an implantable cardiac monitor (ICM) to assess the incidence predictors asymptomatic before after catheter ablation.Patients with symptomatic underwent implantation ICM automated detection algorithm 3 months 18 ablation. Patients kept a standardized diary record symptoms arrhythmia, data were downloaded every months. All...