A5030391846- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- ECG Monitoring and Analysis
- Coronary Interventions and Diagnostics
- Infant Development and Preterm Care
- Phonocardiography and Auscultation Techniques
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiac Arrest and Resuscitation
- Child and Adolescent Health
- Neonatal Respiratory Health Research
- Health Systems, Economic Evaluations, Quality of Life
- Neonatal and fetal brain pathology
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
IMI TAMI Institute for Research and Development
2020-2025
McMaster University
2014-2024
Hamilton Health Sciences
2015-2024
Hamilton General Hospital
2014-2024
McGill University Health Centre
2018-2024
Population Health Research Institute
2015-2024
Western University
2024
Montreal Heart Institute
2024
Health Sciences Centre
2020-2024
Kongsberg Innovasjon (Norway)
2023
Guidelines recommend a trial of one or more antiarrhythmic drugs before catheter ablation is considered in patients with atrial fibrillation. However, first-line may be effective maintaining sinus rhythm. We randomly assigned 303 symptomatic, paroxysmal, untreated fibrillation to undergo cryothermy balloon receive drug therapy for initial rhythm control. All the received an implantable cardiac monitoring device detect tachyarrhythmia. The follow-up period was 12 months. primary end point...
Atrial fibrillation is a chronic, progressive disorder, and persistent forms of atrial are associated with increased risks thromboembolism heart failure. Catheter ablation as initial therapy may modify the pathogenic mechanism alter progression to fibrillation.
Background: Atrial fibrillation (AF) and heart failure (HF) frequently coexist can be challenging to treat. Pharmacologically based rhythm control of AF has not proven superior rate control. Ablation-based was compared with evaluate if clinical outcomes in patients HF could improved. Methods: This a multicenter, open-label trial blinded outcome evaluation using central adjudication committee. Patients high-burden paroxysmal (>4 episodes 6 months) or persistent (duration <3 years) AF,...
Implantable cardioverter defibrillators (ICDs) improve survival in patients at risk for cardiac arrest, but are associated with intravascular lead-related complications. The subcutaneous ICD (S-ICD), no components, was developed to minimize complications.To assess key performance measures related delivery of therapy, including inappropriate shocks (delivered absence life-threatening arrhythmia) and failed (which did not terminate ventricular arrhythmia).Randomized, multicenter trial....
Abstract Major depressive disorder and exposure to antidepressants during pregnancy have been previously associated with preterm birth (PTB). However, the reported results are inconsistent. In this study, we aimed estimate effects of maternal depression on risk PTB using data from electronic health records (EHRs). This is a population-based retrospective cohort utilizing primary care EHRs. The included 216,070 deliveries 176,866 patients UK between January 1996 February 2019. We analyzed...
Safety and efficacy limit currently available atrial fibrillation (AF) therapies. We hypothesized that gene transfer would allow focal manipulation of electrophysiology and, by eliminating reentry, prevent AF.In a porcine AF model, we compared control animals to receiving adenovirus encoded KCNH2-G628S, dominant negative mutant the I(Kr) potassium channel alpha-subunit (G628S animals). After epicardial pacemaker implantation for burst pacing, were evaluated daily cardiac rhythm....
Abstract Background Postpartum depression is a widespread disorder, adversely affecting the well-being of mothers and their newborns. We aim to utilize machine learning for predicting risk postpartum (PPD) using primary care electronic health records (EHR) data, evaluate potential value EHR-based prediction in improving accuracy PPD screening early identification women at risk. Methods analyzed EHR data 266,544 from UK who gave first live birth between 2000 2017. extracted multitude...
BackgroundPatients with ventricular tachycardia and ischemic cardiomyopathy are at high risk for adverse outcomes. Catheter ablation is commonly used when antiarrhythmic drugs do not suppress tachycardia. Whether catheter more effective than as a first-line therapy in patients uncertain.MethodsIn an international trial, we randomly assigned 1:1 ratio previous myocardial infarction clinically significant (defined storm, receipt of appropriate implantable cardioverter–defibrillator [ICD] shock...
Importance With the continuous increase in prevalence of autistic spectrum disorder (ASD), effective early screening is crucial for initiating timely interventions and improving outcomes. Objective To develop predictive models ASD using routinely collected developmental surveillance data to assess their performance predicting at different ages clinical scenarios. Design, Setting, Participants This retrospective cohort study used nationwide assessments conducted between January 1, 2014, 17,...
Background: Polymorphic ventricular tachycardia (VT) without QT prolongation is well described in patients structural heart disease (mainly idiopathic fibrillation and Brugada syndrome) with acute ST-elevation myocardial infarction. Methods: Retrospective study of polymorphic VT related to coronary artery disease, but evidence ischemia. Results: The authors identified 43 whom developed within days an otherwise uncomplicated infarction or revascularization procedure. events were invariably...
Routine developmental screening tests for children are used worldwide early detection of delays. However, assessment milestone norms lacks strong normative data, and there inconsistencies among different tools.To establish build an updated scale.This is a cross-sectional, population-based study conducted between 2014 2020. Developmental assessments were by trained public health nurses, documented in national maternal child clinics, known as Tipat Halav, which serve all Israel. Participants...
BACKGROUND Developmental surveillance, conducted routinely worldwide, is fundamental for early detection of children at risk developmental delay. We aimed to explore sex-related difference in attainment rates milestones and evaluate the clinical need separate sex-specific scales. METHODS This a cross-sectional, natiowide retrospective study, utilizing data from national child surveillance program ∼1000 maternal health clinics. The main cohort, used constructing scales, included all born...
Importance Detecting and addressing potentially modifiable factors associated with healthy development is key to optimizing a child’s potential. When investigating the outcomes of child development, it important account for disparities in feeding practices avoid confounding bias. Objectives To estimate independent association between breastfeeding attainment developmental milestones or neurodevelopmental conditions. Design, Setting, Participants This retrospective cohort study used data from...