A5014806280- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Ion channel regulation and function
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Cardiomyopathy and Myosin Studies
- Neurological disorders and treatments
- Quality and Safety in Healthcare
- Advanced MRI Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Pericarditis and Cardiac Tamponade
- Neuroendocrine Tumor Research Advances
- Coronary Artery Anomalies
- Phytoestrogen effects and research
- Sports injuries and prevention
- Cardiovascular Syncope and Autonomic Disorders
- Growth Hormone and Insulin-like Growth Factors
- Receptor Mechanisms and Signaling
- ECG Monitoring and Analysis
University of British Columbia
2012-2024
Vancouver General Hospital
2015-2024
Queen Elizabeth II Health Sciences Centre
2022
St. Paul's Hospital
1992-2015
Trinity Western University
2015
Western University
2015
Providence Health Care
2015
Centre for Health Evaluation and Outcome Sciences
2015
St George Hospital
2012
St. Paul's Hospital
2004
Background: Atrial fibrillation (AF) and heart failure (HF) frequently coexist can be challenging to treat. Pharmacologically based rhythm control of AF has not proven superior rate control. Ablation-based was compared with evaluate if clinical outcomes in patients HF could improved. Methods: This a multicenter, open-label trial blinded outcome evaluation using central adjudication committee. Patients high-burden paroxysmal (>4 episodes 6 months) or persistent (duration <3 years) AF,...
The ability to record accessory atrioventricular (AV) pathway activation consistently may be uniquely beneficial in improving localization, identifying anatomic relations, and providing insight into unusual conduction properties. For the purpose of recording left AV activation, an electrode catheter was specially designed for use coronary sinus. orthogonal has three sets four electrodes spaced evenly around circumference. Electrograms were recorded at low gain (less than 1 cm/mV) between...
The natural history of frequent premature ventricular complexes (PVCs) in association with preserved left ejection fraction (LVEF) is uncertain. optimal management this population thus undefined. We studied the outcomes untreated patients PVCs and LVEF.This cohort study prospectively evaluated consecutive from 2012 to 2017, asymptomatic or minimally symptomatic idiopathic (≥5% 24 hours; normal LVEF; no cause identified on comprehensive evaluation). No suppressive therapy (ablation...
Same-day discharge is increasingly common after catheter ablation for atrial fibrillation (AF). However, the impact of same-day on healthcare utilization and whether this differs by modality remains uncertain. We examined safety, efficacy, subsequent a protocol AF ablation, including radiofrequency (RF) cryoballoon in contemporary cohort.All consecutive patients whom full data were available at two centres who underwent from 2018 to 2019 included. was default strategy all patients. The...
To determine the effects of isoflavones (soy phyto-estrogens) on serum total cholesterol (TC), low density lipoprotein (LDL), high (HDL) and triglyceride (TG).We searched electronic databases included randomized trials with interventions in forms tablets, isolated soy protein or diets. Review Manager 4.2 was used to calculate pooled risk differences fixed model.Seventeen studies (21 comparisons) 853 subjects were this meta-analysis. Isoflavones tablets had insignificant TC, 0.01 mmol/L (95%...
Holter monitoring may raise suspicion of an underlying catecholaminergic polymorphic ventricular tachycardia (CPVT) diagnosis. Although not a primary investigation for CPVT, is ubiquitously used as diagnostic tool in the heart rhythm clinic.
There is a relative paucity of data linking inappropriate implantable cardioverter-defibrillator (ICD) shocks to adverse clinical outcomes.To examine the association between ICD and mortality or heart transplantation in large population cohort.A cohort study which included all subjects who underwent implantation 1998 2008 were followed up at our institution.Multivariable Cox regression analyses conducted investigate effect on risk death transplantation. Appropriate therapies modelled as...
The relative effectiveness of medical therapy compared with a conservative approach monitoring in patients idiopathic frequent premature ventricular complexes (PVCs) is uncertain. We evaluated the versus for PVCs.Patients PVCs (≥5%) were prospectively enrolled this cohort study between 2016 and 2020. In normal cardiac function no structural heart disease, those receiving controls without therapy. Patients followed longitudinally change PVC burden serial echocardiography.Overall, 120 met...
Regional differences in rabbit atrial repolarization were investigated using a conventional microelectrode technique. A more rapid phase 1 (lower amplitude) was seen the left (LA) roof area compared with right (RA) area: 54 +/- 10 vs. 82 6 mV at 1,000 ms (P < 0.001). In addition, action potential duration 40 above resting (APD40) shorter LA and associated slower 3 rate. Furthermore, recovery time constant of amplitude 500 0.9 0.2 s 3.5 1.5 RA Pacing cycle lengths (2,000, 1,500, 1,000,...
Medtronic's Lead Integrity Alert (LIA) software algorithm is useful for detecting abnormal parameters across various ICD-lead families. However, its utility in the assessment of Biotronik Linox™ family high-voltage (HV) leads unknown.We conducted a retrospective cohort study to assess performance LIA detect abnormalities and lead failure Linox ICD-leads. All LIA-enabled Medtronic devices connected an active were included. The alerts adjudicated by 2 blinded electrophysiologists correlated...
Background: Regulatory authorities of most industrialized countries recommend 6 months private driving restriction after implantation a secondary prevention implantable cardioverter-defibrillator (ICD). These restrictions result in significant inconvenience and social implications. This study aimed to assess the incidence rate appropriate device therapies contemporary recipients ICD. Methods: retrospective at 3 Canadian tertiary care centers enrolled consecutive patients with new ICD...
Catheter ablation of the atrioventricular (AV) node with radiofrequency current (RFC) is associated short-term onset a junctional escape rhythm (JER) in nearly all patients. However, origin JER and thermal effects RFC on this pacemaker activity are ill defined.Short-term noninvasive long-term follow-up studies were performed to examine electrophysiological characteristics underlying 45 patients who had undergone AV nodal RFC. Baseline responses overdrive ventricular pacing intravenous...